2016

First cyborg bacteria developed

The article describes our latest Cyborg cells! By interfacing bacterial cells to a computer through optogenetics, we are able to build an automated, light-mediated feedback control system for controling cellular processes. We demonstrate this technology by using it to achieve very precise and robust regulation of gene expression and cell growth.

This article introduces a new motif for biologically implementing integral feedback.

How Molecules Can Do Statistics

This article shows theoretically and experimentally how optimal noise filters can be realized as biochemical circuits. Those can be understood as molecular counterparts of the Kalman filter.

The article reports a method to measure and analyze mRNA and proteins simulatenously in single mammalian cells.

Control techniques for cells

Introducing a new regulation motif, our article demonstrates how precision and noise can work in accord when antithetic integral feedback is employed to maintain homeostasis.