The Control Theory and Systems Biology Laboratory is led by Prof. Mustafa Khammash. It is part of the Department of Biosystems Science and Engineering (D-BSSE) of ETH Zurich, located in the city of Basel.
Our group works at the interface of systems biology, synthetic biology, and control theory. We develop theory and novel computational methods for the modeling, simulation, analysis, and control of biological networks, with a focus on stochastic systems. We utilize these methods for reverse engineering biological networks, with particular interest in understanding the role of dynamics, feedback, and randomness. Additionally, we leverage our methods for forward engineering novel synthetic biological circuits.
Our team combines engineers, mathematicians, computational scientists, physicists, and biologists. Our theoretical and computational studies of biosystems is complemented by experimental studies. Our group runs an experimental biology laboratory equipped for biosafety level I microbiology and molecular biology work and has access to the D-BSSE departments extensive facilities including the Single Cell Facility, Quantitative Genomics Facility, the Laboratory Automation Facility, and the Center for Information Sciences and Databases.