The Control Theory and Systems Biology Laboratory is led by Professor Mustafa Khammash. Our group works at the interface of systems biology, synthetic biology, and control theory. We develop theory and novel computational methods for the modeling, simulation, analysis, and control of biological networks. We utilize these methods for reverse engineering biological complexity, with particular interest in understanding the role of dynamics, feedback, and randomness. Additionally, we leverage our methods for forward engineering novel synthetic biological circuits.
Our team combines engineers, mathematicians, computational scientists, physicists, and biologists. Our theoretical and computational studies of biosystems is complemented by experimental studies. Our group runs an experimental biology laboratory equipped for biosafety level I microbiology and molecular biology work and has access to the D-BSSE departments extensive facilities including the Single Cell Facility, Quantitative Genomics Facility, the Laboratory Automation Facility, and the Center for Information Scineces and Databases.