Publications
external pageGoogle Scholarcall_made
Lab members in bold. Paper links in blue. Updated May 2023
(35) external pageUsing CRISPR to study gene function aids understanding of 22q11.2 deletion syndromecall_made. Santinha, A.J. and Platt RJ. Nature (2023).
(34) external pageTranscriptional linkage analysis with in vivo AAV-Perturb-seqcall_made. Santinha, A.J., Klingler, E., Kuhn, M. et al. Nature (2023).
(33) external pageCRISPR for neuroscientistscall_made. Kalamakis G and Platt RJ. Neuron (2023)
(32) external pageMicrobial medics: engineered bacteria that diagnose, monitor and treat intestinal inflammationcall_made. Tanna T and Platt RJ. Cell Host & Microbe (2023)
(31) external pageNon-invasive assessment of gut function with transcriptional recording sentinel cellscall_made. Schmidt F*, Zimmermann J*, Tanna T*, Farouni R, Conway T, Macpherson AJ^, Platt RJ^. Science (2022) *co-first ^co-last
external pageScience Perspectivecall_made | external pageNat Rev Microcall_made | ETH News | | external pageInsel Newscall_made | external pageBRCCH Newscall_made | external pageGEN Newscall_made | external pageNat. Rev. Gastroenterol. Hepatol.call_made | external pageNat. Chem. Biolcall_made
(30) external pageAn in vivo CRISPR screen identifies stepwise genetic dependencies of metastatic progressioncall_made. Scheidmann MC, Castro-Giner F, Paasinen-Sohns A, Strittmatter K, Krol I, Scherrer R, Donato C, Szczerba BM, Gkountela S, Kunz L, Schroeder T, Vetter M, Rochlitz C, Platt RJ, Aceto N. Cancer Research (2022)
(29) external pageMiR-137 and miR-122, two outer subventricular zone-enriched non-coding RNAs, regulate basal progenitor expansion and neuronal differentiationcall_made. Tomasello U, Klingler E, Niquille M, Mule N, de Vevey L, Prados J, Santinha AJ, Platt RJ, Borrell V, Jabaudon D, Dayer A. Cell Reports (2022)
(28) external pageTemporal controls over inter-areal cortical projection neuron fate diversitycall_made. Klingler E, Prados J, Kebschull J M, Santinha AJ, Platt RJ, Dayer A, Zador AM, Jabaudon D. Nature (2021)
(27) external pageMultiplexed genome engineering with Cas12acall_made. Weisbach NR, Meijs A, Platt RJ. Methods in Molecular Biology (2021)
(26) external pageRecording biological information with CRISPR-Cas systemscall_made. Cherepkova MY, Tanna T, Platt RJ. American Society for Microbiology (2022)
(25) external pageMoving from in vitro to in vivo CRISPR screenscall_made. Kuhn M, Santinha AJ, Platt RJ. Gene and Genome Editing (2021)
(24) external pageVoices of biotech researchcall_made. Annabi N, Baker M, Boettiger A, Chakraborty D, Chen Y, Corbett KS, Correia B, Dahlman J, de Oliveira T, Ertuerk A, Yanik MF, Henaff E, Huch M, Iliev ID, Jacobs T, Junca H, Keung A, Kolodkin-Gal I, Krishnaswamy S, Lancaster M, Macosko E, Martínez-Núñez MA, Miura K, Molloy J, Ochoa Cruz A, Platt RJ, Posey AD, Shao H, Simunovic M, Slavov N, Takebe T, Vandenberghe LH, Varshney RK, Wang J. Nature Biotechnology (2021)
(23) external pageRegulation of AMP synthesis by a KCTD13 ubiquitin ligase connects 16p11.2 deletion syndrome to a metabolic disorder with autistic featurescall_made. Madison J, Duong K, Vieux E, Udeshi N, Iqbal S, Requadt E, Fereshetian S, Lewis M, Gomes A, Pierce K, Platt RJ, Zhang F, Campbell A, Lal D, Wagner F, Clish C, Carr S, Sheng M, Scolnick E, Cottrell J. iScience (2021)
(22) external pageEngineered bacteria to report gut function: technologies and implementationcall_made. Tanna T*, Ramachanderan R*, Platt RJ. Current Opinion in Microbiology (2020) *co-first
(21) external pageRecording transcriptional histories using Record-seqcall_made. Tanna T*, Schmidt F*, Cherepkova MY, Okoniewski M, Platt RJ. Nature Protocols (2020) *co-first [paper resources]
(20) external pageCRISPR tool modifies genes precisely by copying RNA into the genomecall_made. Platt RJ. Nature (2019)
(19) external pageLinking human phenotype to genotype with single-cell genomicscall_made. Camp JG, Platt RJ, Treutlein B. Science (2019)
(18) external pageMultiplexed genome engineering by Cas12a and CRISPR arrays encoded on single transcriptscall_made. Campa CC*, Weisbach NR*, Santinha A, Incarnato D, Platt RJ. Nature Methods (2019) *co-first [paper resources]
(17) external pageTranscriptional recording by CRISPR spacer acquisition from RNAcall_made. Schmidt F, Cherepkova MY, Platt RJ. Nature (2018) [paper resources]
external pageThe Scientistcall_made | external pageNaturecall_made | external pageNature Biotechnologycall_made | external pageNature Methodscall_made | external pageNature Chemical Biologycall_made | ETH News
(16) external pageMapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR–mediated direct in vivo screeningcall_made. Wang G*, Chow RD*, Ye L, Guzman CD, Dai X, Dong MB, Zhang F, Sharp PA, Platt RJ^, Chen S^. Science Advances (2018) *co-first ^co-corresponding
(15) external pageAAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastomacall_made. Chow RD*, Guzman CD*, Wang G*, Schmidt F*, Youngblood MW, Ye L, Errami Y, Dong MB, Martinez MA, Zhang S, Renauer P, Bilguvar K, Gunel M, Sharp PA, Zhang F, Platt RJ^, Chen S^. Nature Neuroscience (2017) *co-first ^co-corresponding (external pagedeposited on bioRxivcall_made)
(14) external pageApplications of CRISPR-Cas for synthetic biology and genetic recording.call_made Schmidt F, Platt RJ. Current Opinion in Systems Biology (2017)
(13) external pageThyroid hormone receptor beta and NCOA4 regulate terminal erythrocytedifferentiationcall_made. Gao X, Lee HY, Li W, Platt RJ, Barrasa MI, Ma Q, Elmes RR, Rosenfeld MG, Lodish HF. PNAS (2017)
(12) external pageChd8 mutation leads to autistic-like behaviors and impaired striatal circuits.call_made Platt RJ^, Zhou Y, Slaymaker IM, Shetty AS, Weisbach NR, Kim JA, Sharma J, Desai M, Sood S, Kempton HR, Crabtre GR, Feng G, Zhang F^. Cell Reports (2017) ^co-corresponding
(11) external pageGenome-Scale CRISPR-Cas9 Knockout and Transcriptional Activation Screening.call_made Joung J, Konermann S, Gootenberg J, Abudayyeh O, Platt RJ, Sanjana NE, Brigham MD, Zhang F. Nature Protocols (2017) (external pagedeposited on bioRxivcall_made)
(10) external pageMicrofluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units.call_made Uzel SG, Platt RJ, Subramanian V, Pearl TM, Rowlands CJ, Chan V, Boyer LA, So PT, Kamm RD. Science Advances (2016)
(9) external pageOptogenetic skeletal muscle-powered adaptive biological machines.call_made Raman R, Cvetkovic C, Uzel SG, Platt RJ, Sengupta P, Kamm RD, Bashir R. PNAS (2016)
(8) external pageA Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks.call_made Parnas O, Jovanovic M, Eisenhaure TM, Herbst RH, Dixit A, Ye CJ, Przybylski D, Platt RJ, Tirosh I, Sanjana NE, Shalem O, Satija R, Raychowdhury R, Mertins P, Carr SA, Zhang F, Hacohen N, Regev A. Cell (2015)
(7) external pageTherapeutic genome editing: prospects and challenges.call_made Cox DB, Platt RJ, Zhang F. Nature Methods (2015)
(6) external pageCRISPR-Cas9 knockin mice for genome editing and cancer modeling.call_made Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Sharp PA, Zhang F. Cell (2014) [paper resources]
(5) external pageEfficient CRISPR-Cas9-mediated genome editing in Plasmodium falciparum.call_made Wagner JC, Platt RJ, Goldfless SJ, Zhang F, Niles JC. Nature Methods (2014)
(4) external pageFrom molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypes.call_made Platt RJ, Curtice KJ, Twede VD, Watkins M, Gruszczyński P, Bulaj G, Horvath MP, Olivera BM. Toxicon (2014)
(3) external pageOptical control of mammalian endogenous transcription and epigenetic states.call_made Konermann S, Brigham MD, Trevino AE, Hsu PD, Heidenreich M, Cong L, Platt RJ, Scott DA, Church GM, Zhang F. Nature (2013)
(2) external pageConantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits.call_made Gowd KH, Han TS, Twede V, Gajewiak J, Smith MD, Watkins M, Platt RJ, Toledo G, White HS, Olivera BM, Bulaj G. Biochemistry (2012)
(1) external pageStapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors.call_made Platt RJ, Han TS, Green BR, Smith MD, Skalicky J, Gruszczynski P, White HS, Olivera B, Bulaj G, Gajewiak J. Journal of Biological Chemistry (2012)