icbn
Isotonic regression Conjunctive Bayesian Network models
Current version
0.2-13 Aug 2010
Description
The R package icbn implements algorithms for parameter estimation and model selection for Isotonic Conjunctive Bayesian Network (I-CBN) models. I-CBNs combine isotonic regression on a partially ordered set with CBNs for estimating order constraints among events. The model has been developed to jointly estimate mutational order constraints among genetic events and a genotype-phenotype mapping (such as a fitness landscape) that is non-decreasing along the lattice of genotypes.
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icbn is distributed under the external pageGNU General Public Licensecall_made.
Authors and Contributors
Citation
- Learning monotonic genotype-phenotype maps
Niko Beerenwinkel, Patrick Knupfer and Achim Tresch
external pageStat Appl Genet Mol Biol 10 (3)call_made