Firing patterns in human and murine brain organoids do not arise in experience-dependent manner, but are constrained by preconfigured architecture established during neurodevelopment.
Open microfluidic platform developed that enables co-culturing of 3D tissue spheroids and circulating cells over days. Fluid flow to recirculate cells and promote distribution of cell-secreted factors and nutrients established by device tilting.
Manon Murdeu received Gerhard Zbinden Early Career Award (ECA) and IN2TOX speciality section award for best poster presentation at EUROTOX 2025 in Athens for contribution "Human-based placenta-embryo chip for developmental toxicity assessment of nanoparticles and drugs."