Multi-Locus Mapping of Genetic Heterogeneity (FAIS)

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Felipe Llinares-López, Dominik G. Grimm, Dean A. Bodenham, Udo Gieraths, Mahito Sugiyama, Beth Rowan, Karsten Borgwardt

Genome-wide detection of intervals of genetic heterogeneity associated with complex traits

Summary

We present an algorithm for discovering contiguous sets of SNPs in a genome that are associated to a phenotype of interest under a model of genetic heterogeneity. The algorithm can search any contiguous set of SNPs in the genome and still properly correct for mutiple testing, while retaining statistical power.

Code

Beta version of code can be accessed here (ZIP, 70 KB)

Please read readme.txt before using.

Reference

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Felipe Llinares-López, Dominik G. Grimm, Dean A. Bodenham, Udo Gieraths, Mahito Sugiyama, Beth Rowan and Karsten Borgwardt
Genome-wide detection of intervals of genetic heterogeneity associated with complex traits,

ISMB 2015, Bioinformatics (2015) 31 (12): i240-i249. (Online)

@article{Llinares-Lopez15062015,
author = {Llinares-L\'{o}pez, Felipe and Grimm, Dominik G. and Bodenham, Dean A. and Gieraths, Udo and Sugiyama, Mahito and Rowan, Beth and Borgwardt, Karsten},
title = {Genome-wide detection of intervals of genetic heterogeneity associated with complex traits},
volume = {31},
number = {12},
pages = {i240-i249},
year = {2015},
doi = "10.1093/bioinformatics/btv263",
URL = {http://bioinformatics.oxfordjournals.org/content/31/12/i240.abstract},
eprint = {http://bioinformatics.oxfordjournals.org/content/31/12/i240.full.pdf+html},
journal = {Bioinformatics}
}

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