LMM-Lasso

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Barbara Rakitsch, Christoph Lippert, Oliver Stegle, Karsten Borgwardt

A Lasso Multi-Marker Mixed Model for Association Mapping with Population Structure Correction

Summary

We present a linear model with sparsity constraints (Lasso model) for association mapping and phenotype prediction, which corrects for population strucure.

Code

The code is written in Python and can be downloaded here (ZIP, 214 KB) (last update: 20 November 2013).

Reference

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Barbara Rakitsch, Christoph Lippert, Oliver Stegle, Karsten Borgwardt
A Lasso Multi-Marker Mixed Model for Association Mapping with Population Structure Correction,
Bioinformatics 2013 Jan 15;29(2):206-1. (Online)

@article{Rakitsch15012013,
author = {Rakitsch, Barbara and Lippert, Christoph and Stegle, Oliver and Borgwardt, Karsten},
title = {A {L}asso multi-marker mixed model for association mapping with population structure correction},
volume = {29},
number = {2},
pages = {206-214},
year = {2013},
doi = "10.1093/bioinformatics/bts669",
URL = {http://bioinformatics.oxfordjournals.org/content/29/2/206.abstract},
eprint = {http://bioinformatics.oxfordjournals.org/content/29/2/206.full.pdf+html},
journal = {Bioinformatics}
}

 
 
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22.03.2017
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