Cell Systems Dynamics Group

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2024 | 2023 | 2022 | 2021 | 2020 |2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2000 | 1999

Please note: PDF files available upon request: Timm Schroeder

Group members in bold.
Publications from Timm Schroeder’s groups until 2013 also shown.

2024

Rai, Zhang, Grockowiak, Kimmerlin, Hansen, Stoll, Usart, Luque Paz, Hao-Shen, Zhu, Roux, Bader, Dirnhofer, Farady, Schroeder, Méndez-Ferrer, Skoda
external pageIL-1β promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells
Blood Advances, Online ahead of print

Mueller*, Schimmer*, Koch, Schneiter, Fullin, Lysenko, Pellegrino, Klemm, Russkamp, Myburgh, Volta, Theocharides, Kurppa, Ebert, Schroeder, Manz*, Boettcher*
external pageTargeting the mevalonate or Wnt pathways to overcome CAR T-cell resistance in TP53-mutant AML cells
EMBO Molecular Medicine, Online ahead of print

Kockwelp*, Thiele*, Bartsch*, Haalck, Gromoll, Schlatt, Exeler, Bleckmann, Lenz, Wolf, Steffen, Berdel, Schliemann, Risse, Angenendt
external pageDeep Learning Predicts Therapy-Relevant Genetics in Acute Myeloid Leukemia from Pappenheim-stained Bone Marrow Smears
Blood Advances, 8(1):70-79
- highlighted in this external pagecommentary

2023

Arekatla, Trenzinger, Reimann, Loeffler, Kull, Schroeder
external pageOptogenetic manipulation identifies the roles of ERK and AKT dynamics in controlling mouse embryonic stem cell exit from pluripotency
Developmental Cell, 58(12):1022-1036
-highlighted in this external pagecommentary

Reimann*, Kull*, Wang, Dettinger, Loeffler, Schroeder
external pageEmbryonic stem cell ERK, AKT plus STAT3 response dynamics combinatorics are heterogeneous but NANOG state independent
Stem Cell Reports, 18(6):1295-1307

Stetka, Usart, Kubovcakova, Rai, Rao, Sutter, Hao-Shen, Dirnhofer, Geier, Bader, Passweg, Manolova, Dürrenberger, Ahmed, Schroeder, Ganz, Nemeth, Silvestri, Nai, Camaschella, Skoda
external pageIron is a modifier of the phenotypes of JAK2-mutant myeloproliferative neoplasms
Blood, 141(17):2127-2140

Barz*, Behrmann*, Capron*, Zuchtriegel*, Steffen, Kunz, Zhang, Jimenez Vermeerbergen, Marovca, Kirschmann, Rinaldi, Zech, Nombela-Arrieta, Ziegler, Schroeder, Bornhauser, Bourquin
external pageB and T cell acute lymphoblastic leukemia evade chemotherapy at distinct sites in the bone marrow
Haematologica, 108(5):1244-1258

Angenendt, Röllig, Montesinos, Ravandi, Juliusson, Récher, Itzykson, Ráčil, Wei, Schliemann
external pageRevisiting Co-existing Chromosomal Abnormalities in NPM1-mutated AML in Light of the Revised ELN 2022 classification
Blood, 141(4):433-435

Gräbnitz, Stark, Shlesinger, Petkidis, Borsa, Yermanos, Carr, Barandun, Wehling, Balaz, Schroeder, Oxenius
external pageAsymmetric cell division safeguards memory CD8 T cell development
Cell Reports, 42(5):112468

Vinopal, Dupraz, Alfadil, Pietralla, Bendre, Stiess, Falk , Camargo Ortega, Maghelli , Tolić, Smejkal, Götz, Bradke
external pageCentrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brain
Neuron, 111(8):1241-1263

Beneyto-Calabuig, Merbach, Kniffka, Antes, Szu-Tu, Rohde, Waclawiczek, Stelmach, Gräßle, Pervan, Janssen, Landry, Benes, Jauch, Brough, Bauer, Besenbeck, Felden, Bäumer, Hundemer, Sauer, Pabst, Wickenhauser, Angenendt, Schliemann, Trumpp, Haas, Scherer, Raffel, Müller-Tidow, Velten
external pageClonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia
Cell Stem Cell, 30(5):706-721
  

2022

Wehling, Loeffler, Zhang, Kull, Donato, Szczerba, Camargo Ortega, Lee, Moor, Goettgens, Aceto, Schroeder
external pageCombining single-cell tracking and omics improves blood stem cell fate regulator identification
Blood, 140(13):1482-1495

Loeffler*, Schneiter*, Wang, Wehling, Kull, Lengerke, Manz, Schroeder
external pageAsymmetric organelle inheritance predicts human blood stem cell fate
Blood, 139(13):2011-2023
-highlighted in this external pagecommentary
-highlighted in this external pagecommentary

Kull, Wehling, Etzrodt, Auler, Dettinger, Aceto, Schroeder
external pageNfκB signaling dynamics and their target genes differ between mouse blood cell types and induce distinct cell behavior
Blood, 140(2):99-111
-highlighted in this external pagecommentary

Ahmed, Etzrodt, Dettinger, Kull, Loeffler, Hoppe, Chavez, Zhang, Ortega, Hilsenbeck, Nakajima, Pietras, Schroeder
external pageBlood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation
Journal of Experimental Medicine, 219(1):e20202490

Dettinger**, Kull, Arekatla, Ahmed, Zhang, Schneiter, Wehling, Schirmacher, Kawamura, Loeffler, Schroeder**
external pageOpen-source personal pipetting robots with live-cell incubation and microscopy compatibility
bioRxiv 2021; doi /10.1101/2021.07.04.448641
Nature Communications, 13(1):2999
"Editor's external pageHighlight" 

Plambeck, Kazeroonian, Loeffler, Kretschmer, Salinno, Schroeder, Busch, Flossdorf, Buchholz
external pageHeritable changes in division speed accompany the diversification of single T cell fate
PNAS, 119(9):e2116260119

Scheidmann, Castro-Giner, Strittmatter, Krol, Paasinen-Sohns, Scherrer, Donato, Gkountela, Szczerba, Diamantopoulou, Muenst, Vlajnic, Kunz, Vetter, Rochlitz, Taylor, Giachino, Schroeder, Platt, Aceto
external pageAn In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression
Cancer Research, 82(4):681-694

Camargo, Goetz
external pageCentrosome heterogeneity in stem cells regulates cell diversity
Trends in Cell Biology, S0962-8924(22)00076-9

Angenendt, Mikesch, Schliemann
external pageEmerging antibody-based therapies for the treatment of acute myeloid leukemia
Cancer Treatment Reviews, 108:102409

Berdel, Ruhnke, Angenendt, Wermke, Röllig, Mikesch, Scheller, Hemmerle, Matasci, Wethmar, Kessler, Gerwing, Hescheler, Schäfers, Hartmann, Altvater, Rossig, Bornhäuser, Lenz, Stelljes, Rueter, Neri, Berdel, Schliemann
external pageUsing stroma-anchoring cytokines to augment ADCC: a phase 1 trial of F16IL2 and BI 836858 for posttransplant AML relapse
Blood Advances, 28;6(12):3684-3696

2021

Wang*, Zhang*, Dettinger, Reimann, Kull, Loeffler, Manz, Lengerke, Schroeder
external pageCytokine combinations for human blood stem cell expansion induce cell type- and cytokine-specific signaling dynamics
Blood, 138(10):847-857
-highlighted in this external pagecommentary

Kull and Schroeder
external pageAnalyzing signaling activity and function in hematopoietic cells
Journal of Experimental Medicine, 218(7):e20201546

Loeffler and Schroeder
external pageSymmetric and asymmetric activation of hematopoietic stem cells
Current Opinion in Hematology, 28(4):262-268

Chavez, Rabe, Loeffler, Higa, Hernandez, Mills, Ahmed, Gessner, Ke, Idler, Kim, Myers, Stevens, Jordan, Nakajima, Ashton, Welner, Schroeder, DeGregori, Pietras
external pagePU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress
bioRxiv (2020), 20200520
Journal of Experimental Medicine, 218(6):e20201169

García-Prat, Kaufmann, Schneiter, Voisin, Murison, Chen, Chan-Seng-Yue, Gan, McLeod, Smith, Shoong, Paris, Pan, Zeng, Krivdova, Gupta, Takayanagi, Wagenblast, Wang, Lupien, Schroeder, Xie, Dick
Dichotomous regulation of lysosomes by MYC and TFEB controls hematopoietic stem cell fate
bioRxiv, 20210224
external pageTFEB-mediated endo-lysosomal activity controls hematopoietic stem cell fate
Cell Stem Cell, 28(10):1838-1850

Hausmann, Felmy, Kunz, Kroon, Berthold, Ganz, Sandu, Nakamura, Zangger, Zhang, Dolowschiak, Fattinger, Furter, Müller-Hauser, Barthel-Scherrer, Vlantis, Wachsmuth, Kisielow, Tortola, Heide, Heikenwälder, Oxenius, Kopf, Schroeder, Pasparakis, Sellin, Hardt
external pageIntercrypt Sentinel Macrophages Induce a Tunable Antibacterial NFκB Response in Intestinal Epithelial Cells via TNF
Journal of Experimental Medicine, 218(11):e20210862

Wanet, Bassal, Lourenco, Mariani, Ahmed, Borchiellini, Chen, Zhang, Di Ruscio, Miyake, Tsai, Paranjape, Park, Silberstein, Karasuyama, Schroeder, Dzierzak, Galli, Tenen, Welner
external pageE–cadherin is regulated by GATA-​2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates
Science Immunology, 6(56):eaba0178

Xie, Kaufmann, Wang, Chan-​Seng-Yue, Gan, Laurenti, Garcia-​Prat, Takayanagi, Ng, Xu, Zeng, Jin, McLeod, Mitchell, Kennedy, Liu, Boutzen, Kleinau, Jargstorf, Holmes, Zhang, Voisin, Bader, Wang, Hannun, Luberto, Schroeder, Minden, Dick
external pageSphingosine-​1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation
Blood Cancer Discovery, 2(1):32-53

Le Mercier, Bonnavion, Yu, Wessam Alnouri, Zhang, Jäger, Cho, Chen, Strilic, Sijmonsma, Adams, Schroeder, Rieger, Offermanns
external pageGPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis
PNAS, 118(17):e2021596118

Rao, Hansen, Stetka, Paz, Kalmer, Hilfiker, Endele, Ahmed, Kubovcakova, Rybarikova, Hao-Shen, Geier, Beisel, Dirnhofer, Schroeder, Brümmendorf, Wolf, Koschmieder, Skoda
external pageJAK2-V617F and interferon-α induce megakaryocyte-biased stem cells characterized by decreased long-term functionality
Blood, 137(16):2139-2151

Nguyen, Misun, Lohasz, Lee, Wang, Schroeder, Hierlemann
external pageAn immunocompetent microphysiological system to simultaneously investigate effects of anti-tumor natural killer cells on tumor and cardiac microtissues
Frontiers in Immunology, 12:781337

Schaberg, Theocharidis, May, Lessmann, Schroeder, Faissner
external pageSulfation of glycosaminoglycans modulates the cell cycle of embryonic mouse spinal cord neural stem cells
Frontiers Cell and Developmental Biology, 9:643060

Ohteki, Kawamura, Onai
external pageCommitment to dendritic cells and monocytes
International Immunology, dxab031

Cable, Elowitz, Domingos, Habib, Itzkovitz, Hamidzada, Balzer, Yanai, Liberali, Whited, Streets, Cai, Stergachis, Hong, Keren, Guilliams, Alon, Shalek, Hamel, Pfau, Raj, Quake, Zhang, Fan, Trapnell, Wang, Greenwald, Vento-Tormo, Santos, Spencer, Garcia, Arekatla, Gaiti, Arbel-Goren, Rulands, Junker, Klein, Morris, Murray, Galloway, Ratz, Romeike.
external pageSingle cell biology-a Keystone Symposia report.
ANYAS, 1506(1):74-97

2020

Kokkaliaris KD, Kunz L, Cabezas-Wallscheid N, Christodoulou C, Renders S, Camargo F, Trumpp A, Scadden DT, Schroeder T (2020)
external pageAdult blood stem cell localization reflects the abundance of reported bone marrow niche cell types and their combinations
Blood 136(20): 2296–2307

Ahmed N, Kunz L, Hoppe PS, Loeffler D, Etzrodt M, Ortega GC, Hilsenbeck O, Anastassiadis K, Schroeder T (2020)
external pageA novel GATA2 protein reporter mouse reveals hematopoietic progenitor cell types
Stem Cell Reports, 15(2): 326–339

Dettinger P, Wang W, Ahmed N, Zhang Y, Löffler D, Kull K, Etzrodt M, Lengerke C, Schroeder T (2020)
external pageAn Automated Microfluidic System for Efficient Capture of Rare Cells and Rapid Flow-free Stimulation
Lab on a Chip, 10.1039/D0LC00687D

Loeffler D, Schneiter F, Schroeder T (2020)
external pagePitfalls and requirements in quantifying asymmetric mitotic segregation
ANYAS, 1466(1):73-82

Christodoulou C, Spencer JA, Turcotte R, Kokkaliaris KD, Panero R, Ramos A, Esipova TV, Vinogradov SA, Perkins AS, Schroeder T, Lin CP, Camargo FD (2020)
external pageLive-animal imaging of native hematopoietic stem and progenitor cells
Nature, 578(7794):278-283

Altamura S, Vegi NM, Hoppe PS, Schroeder T, Aichler M, Walch A, Okreglicka K, Hültner L, Schneider M, Ladinig C, Kuklik-Roos C, Mysliwietz J, Janik D, Neff F, Rathkolb B, Hrabé de Angelis M, Buske C, da Silva AR, Muedder K, Conrad M, Ganz T, Kopf M, Muckenthaler MU, Bornkamm GW (2020)
external pageGlutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis.
Haematologica, 105(4):937-950

Donato C, Kunz L, Castro-Giner F, Paasinen-Sohns A, Strittmatter K, Szczerba BM, Scherrer R, Di Maggio N, Heusermann W, Biehlmaier O, Beisel C, Vetter M, Rochlitz C, Weber WP, Banfi A, Schroeder T, Aceto N (2020)
external pageHypoxia Triggers the Intravasation of Clustered Circulating Tumor Cells
Cell Reports, 32(10):108105

Rajendiran S, Smith-Berdan S, Kunz L, Risolino M, Selleri L, Schroeder T, Forsberg EC (2020)
external pageUbiquitous Overexpression of CXCL12 Confers Radiation Protection and Enhances Mobilization of Hematopoietic Stem and Progenitor Cells
Stem Cells, 10.1002/stem.3205

Bernitz JM, Rapp K, Daniel MG, Shcherbinin D, Yuan Y, Gomes A, Waghray A, Brosh R, Lachmann A, Ma'ayan A, Papatsenko D, Moore KA (2020)
external pageMemory of Divisional History Directs the Continuous Process of Primitive Hematopoietic Lineage Commitment
Stem Cell Reports, 14(4): 561–574.

Matos ÂP, Kauffman A, Vickery C, Naegeli K, Strittmatter L, Sybirna A, van Blijswijk J, Adlung L, Berbasova T, Enterina J, Eismann L, Tierney B, Jordi J, Zhu L, Verkuijl S, Tallorin L, Wehling A, Ogden M, Lammel S, Hasslacher MK, Wuelfroth P, Neumann S, Tidona C, Betz UAK (2020)
external pageSynthetic Biology Category Wins the 350th Anniversary Merck Innovation Cup
Trends in Biotechnology, 38(1):1-4

2019

Loeffler D, Wehling A, Schneiter F, Zhang Y, Müller-Bötticher N, Hoppe PS, Hilsenbeck O, Kokkaliaris K, Endele M and Schroeder T (2019)
external pageAsymmetric lysosome inheritance predicts activation of haematopoietic stem cells
Nature, 573(7774):426-429
-highlighted in this external pagecommentary

Kunz L and Schroeder T (2019)
external pageA 3D tissue-wide digital imaging pipeline for quantitation of secreted molecules shows absence of CXCL12 gradients in bone marrow
Cell Stem Cell, 25(6):846-854

Etzrodt M*, Ahmed N*, Hoppe PS, Loeffler D, Skylaki S, Hilsenbeck O, Kokkaliaris KD, Kaltenbach HM, Stelling J, Nerlov C and Schroeder T (2019)
external pageInflammatory signals directly instruct PU.1 in HSCs via TNF
Blood, blood-2018-02-832998
-highlighted in this external pagecommentary

Loeffler D and Schroeder T (2019)
external pageUnderstanding Cell Fate Control by Continuous Single Cell Quantification
Blood, blood-2018-09-835397

Bourgine PE, Fritsch K, Pigeot S, Takizawa H, Kunz L, Kokkaliaris KD, Coutu DL, Manz MG, Martin I, Schroeder T (2019)
external pageFate Distribution and Regulatory Role of Human Mesenchymal Stromal Cells in Engineered Hematopoietic Bone Organs
iScience, 19:504-513

Tyrkalska SD, Pérez-Oliva AB, Rodríguez-Ruiz L, Martínez-Morcillo FJ, Alcaraz-Pérez F, Martínez-Navarro FJ, Josselin E, Lachaud C, Ahmed N, Schroeder T, Pardo-Sánchez I, Candel S, López-Muñoz A, Choudhuri A, Rossmann MP, Zon LI, Cayuela ML, García-Moreno D, Mulero V (2019)
external pageInflammasome regulates hematopoiesis through cleavage of the master erythroid transcription factor GATA1
Immunity, 51(1):50-63

McKenzie MD, Ghisi M, Oxley EP, Ngo S, Cimmino L, Esnault C, Liu R, Salmon JM, Bell CC, Ahmed N, Erlichster M, Witkowski MT, Liu GJ, Chopin M, Dakic A, Simankowicz E, Pomilio G, Vu T, Krsmanovic P, Su S, Tian L, Baldwin TM, Zalcenstein DA, DiRago L, Wang S, Metcalf D, Johnstone RW, Croker BA, Lancaster GI, Murphy AJ, Naik SH, Nutt SL, Pospisil V, Schroeder T, Wall M, Dawson MA, Wei AH, De The H, Ritchie ME, Zuber J, Dickins RA (2019)
external pageInterconversion between tumorigenic and differentiated states in acute myeloid leukemia
Cell Stem Cell, 25(2):258-272

Berge U, Bochenek D, Schnabel R, Wehling A, Schroeder T, Stadler T, Kroschewski R (2019)
external pageAsymmetric division events promote variability in cell cycle duration in animal cells and Escherichia coli
Nature Communications, 10(1):1901

Kagawa H, Shimamoto R, Kim SI, Oceguera-Yanez F, Yamamoto T, Schroeder T and Woltjen K (2019)
external pageOVOL1 Influences the Determination and Expansion of iPSC Reprogramming Intermediates
Stem Cell Reports, 12(2):319-332

Failmezger H, Dursun E, Dümcke S, Endele M, Poron D, Schroeder T, Krug A and Tresch A (2019)
external pageClustering of samples with a tree-shaped dependence structure, with an application to microscopic time lapse imaging
Bioinformatics, 10.1093/bioinformatics/bty939

2018

Coutu DL* / **, Kokkaliaris KD*, Kunz L* and Schroeder T** (2018)
external pageMulticolor quantitative confocal imaging cytometry
Nature Methods, 15: 39-46

Hastreiter S, Skylaki S, Loeffler D, Reimann A, Hilsenbeck O, Hoppe PS, Coutu DL, Kokkaliaris KD, Schwarzfischer M, Anastassiadis K, Theis FJ and Schroeder T (2018)
external pageInductive and selective effects of GSK3 and MEK inhibition on Nanog heterogeneity in embryonic stem cells
Stem Cell Reports, 11(1):58-69

Bourgine PE*, Klein T*, Paczula A, Shimizu T, Kunz L, Kokkaliaris KD, Coutu DL, Lengerke C, Skoda R, Schroeder T** and Martin I** (2018) **corresponding author
external pageIn vitro biomimetic engineering of a human hematopoietic niche with functional properties
PNAS, 115(25):E5688-E5695

Loeffler D, Wang W, Hopf A, Hilsenbeck O, Bourgine PE, Rudolf F, Martin I and Schroeder T (2018)
external pageMouse and human HSPC immobilization in liquid culture by CD43/CD44-antibody coating
Blood, 131(13):1425-1429

Strasser MK, Hoppe P, Loeffler D, Kokkaliaris K, Schroeder T**, Theis FJ and Marr C** (2018) **corresponding author
external pageLineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm
Nature Communications, 9(1):2697

Bourgine PE, Martin I and Schroeder T (2018)
external pageEngineering human bone marrow proxies
Cell Stem Cell, 22(3):298-301

Dettinger P*, Frank T*, Etzrodt M*, Ahmed N, Reimann A, Trenzinger C, Loeffler D, Kokkaliaris KD, Schroeder T** and Savas Tay** (2018) **corresponding author
external pageAutomated microfluidic system for dynamic stimulation and tracking of single cells
Analytical Chemistry, 90(18):10695–10700

Stadler T*, Skylaki S, Kokkaliaris KD and Schroeder T* (2018)
external pageOn the statistical analysis of single cell lineage trees
Journal of Theoretical Biology, 439: 160-165

Kawamura S and Ohteki T (2018)
external pageMonopoiesis in humans and mice
International Immunology,  30(11):503-509

Frick C, Dettinger P, Renkawitz J, Jauch A, Berger C, Recher M, Schroeder T and Mehling M (2018)
external pageNano-scale microfluidics to study 3D chemotaxis at the single cell level
PLoS ONE, 13(6):e0198330

Shepherd MS, Li J, Wilson NK, Oedekoven CA, Li J, Belmonte M, Fink J, Prick JCM, Pask DC, Hamilton TL, Löffler D, Rao A, Schroeder T, Göttgens B, Green AR and Kent DG (2018)
external pageSingle cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal
Blood, blood-2017-12-821066

Fritsch K, Pigeot S, Feng X, Bourgine PE, Schroeder T, Martin I, Manz MG and Takizawa H (2018)
external pageEngineered humanized bone organs maintain human hematopoiesis in vivo
Experimental Hematology, 61:45-51

Montaner A, da Silva Santana TT, Schroeder T, Einiker-Lamas M, Girardini J, Costa MR and Banchio C (2018).
external pageSpecific Phospholipids Regulate the Acquisition of Neuronal and Astroglial Identities in Post-Mitotic Cells
Scientific Reports, 8: 460

Landeira BS, Santana TT, Araújo JA, Tabet EI, Tannous BA, Schroeder T, Costa MR (2018)
external pageActivity-Independent Effects of CREB on Neuronal Survival and Differentiation during Mouse Cerebral Cortex Development
Cereb Cortex, 28: 538-548

May M, Denecke B, Schroeder T, Götz M and Faissner A (2018)
external pageCell tracking in vitro reveals that the extracellular matrix glycoprotein Tenascin-C modulates cell cycle length and differentiation in neural stem/progenitor cells of the developing mouse spinal cord
Biology Open, 7: bio027730

Saitou K, Tokunaga M, Yoshino D, Sakitani N, Maekawa T, Ryu Y, Nagao M, Nakamoto H, Saito T, Kawanishi N, Suzuki K, Ogata T, Makuuchi M, Takashima A, Sawada K, Kawamura S, Nakazato K, Kouzaki K, Harada I, Ichihara Y and Sawada Y (2018)
external pageLocal Cyclical Compression Modulates Macrophage Function In Situ and Alleviates Immobilization-Induced Muscle Atrophy
Clinical Science, 132(19): 2147-2161

2017

Coutu DL*, Kokkaliaris KD*, Kunz L and Schroeder T (2017)
external pageThree-dimensional map of non-hematopoietic bone and bone marrow cells and molecules
Nature Biotechnology, 35: 1202–1210

Endele M, Loeffler D, Kokkaliaris KD, Hilsenbeck O, Skylaki S, Hoppe PS, Schambach A, Stanley RE and Schroeder T (2017)
external pageCSF-1 induced Src signaling can instruct monocytic lineage choice
Blood, 129: 1691-1701

Hilsenbeck O, Schwarzfischer M, Loeffler D, Dimopoulos S, Hastreiter S, Marr C, Theis FJ and Schroeder T (2017)
external pagefastER: a user-friendly tool for ultrafast and robust cell segmentation in large-scale microscopy
Bioinformatics, 33: 2020-2028

Buggenthin F, Buettner F, Hoppe PS, Endele M, Kroiss M, Strasser M, Schwarzfischer M, Loeffler D, Kokkaliaris KD, Hilsenbeck O, Schroeder T*, Theis FJ* and Marr C* (2017) *corresponding author
external pageProspective identification of hematopoietic lineage choice by deep learning
Nature Methods, 14: 403-406

Wang W, Fujii H, Kim HJ, Hermans K, Usenko T, Xie S, Luo ZJ, Ma J, Lo Celso C, Dick JE, Schroeder T, Krueger J, Wall D, Egeler RM, Zandstra PW (2017)
external pageEnhancement of human hematopoietic stem and progenitor cell engraftment by blocking donor T cell-mediated tumor necrosis factor alpha signaling
Sci Transl Med, 9(421)

Etzrodt M and Schroeder T (2017)
external pageIlluminating stem cell transcription factor dynamics: Long-term single-cell imaging of fluorescent protein fusions
Current Opinion in Biology, 49: 77-83

Cabezas-Wallscheid N, Buettner F, Sommerkamp P, Klimmeck D, Ladel L, Thalheimer F, Pastor-Flores D, Roma L, Renders S, Zeisberger P, Przybylla A, Schönberger K, Scognamiglio R, Altamura S, Florian CM, Fawaz M, Vonficht D, Tesio M, Collier P, Pavlinik D, Geiger H, Schroeder T, Benes V, Dick TP, Rieger MA, Stegle O and Trumpp A (2017)
external pageVitamin A/ Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy
Cell, 169: 807-823.e19

Mohr S, Doebele C, Comoglio F, Berg T, Beck J, Bohnenberger H, Alexe G, Corso J, Ströbel P, Wachter A, Beissbarth T, Schnütgen F, Cremer A, Haetscher N, Göllner S, Rouhi A, Palmqvist L, Rieger MA, Schroeder T, Bönig H, Müller-Tidow C, Kuchenbauer F, Schütz E, Green AR, Urlaub H, Stegmaier K, Humphries RK, Serve H and Oellerich T (2017)
external pageHoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia
Cancer Cell, 31: 549-562

Lang F, Wojcik B, Bothur S, Knecht C, Falkenburg FJH, Schroeder T, Serve H, Ottmann OG, Rieger MA (2017)
external pagePlastic CD34 and CD38 expression in adult B-precursor acute lymphoblastic leukemia explains ambiguity of leukemia-initiating stem cell populations
Leukemia, 31:731-734

Peng T, Thorn K, Schroeder T, Wang L, Theis F, Marr C, Navab N (2017)
external pageA BaSiC Tool for Background and Shading Correction of Optical Microscopy Images
Nature Communications, 8: 14836

Yuan GC, Cai L, Elowitz M, Enver T, Fan G, Guo G, Irizarry R, Kharchenko P, Kim J, Orkin S, Quackenbush J, Saadatpour A, Schroeder T, Shivdasani R, Tirosh I (2017)
external pageChallenges and emerging directions in single-cell analysis
Genome Biology, 18:84

Kellogg RA, Tian C, Etzrodt M, Tay S (2017)
external pageCellular Decision Making by Non-Integrative Processing of TLR Inputs
Cell Reports, 19: 125-135

Chouchane M, Melo de Farias AR, Moura DMS, Hilscher MM, Schroeder T, Leão RN, Costa MR (2017)
external pageLineage Reprogramming of Astroglial Cells from Different Origins into Distinct Neuronal Subtypes
Stem Cell Reports, 9: 162-176

Landeira BS, Alves de Medeiros Araújo J, Schroeder T, Müller U, Costa MR (2017)
external pageLive imaging of primary cerebral cortex cells using a 2D culture system
JoVE, 126

Gomez-Villafuertes R, Paniagua-Herranz L, Gascón S, de Agustin-Duran D, de la O Ferreras M, Gil-Redondo JC, José Queipo M, Menendez-Mendez A, Pérez-Sen R, Delicado EG, Gualix J, Costa MR, Schroeder T, Miras-Portugal MT, Ortega F (2017)
external pageLive imaging followed by single cell tracking to monitor cell biology and lineage progression of multiple neural populations
JoVe, 130

2016

Hoppe PS, Schwarzfischer M, Loeffler D, Kokkaliaris KD, Hilsenbeck O, Moritz N, Endele M, Filipczyk A, Gambardella A, Ahmed N, Etzrodt M, Coutu DL, Rieger MA, Marr C, Strasser M, Schauberger B, Burtscher I, Ermakova O, Bürger A, Lickert H, Nerlov C, Theis FJ and Schroeder T (2016)
external pageEarly myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios
Nature, 535: 299-302

Hilsenbeck O*, Schwarzfischer M*, Skylaki S*, Schauberger B, Hoppe PS, Loeffler D, Kokkaliaris KD, Hastreiter S, Skylaki E, Filipczyk A, Strasser M, Buggenthin F, Feigelman JS, Krumsiek J, van den Berg AJJ, Endele M, Etzrodt M, Marr C, Theis FJ* and Schroeder T* (2016)
external pageSoftware tools for single-cell tracking and quantification of cellular and molecular properties
Nature Biotechnology, 34: 703-706

Kokkaliaris KD, Drew E, Endele M, Loeffler D, Hoppe PS, Hilsenbeck O, Schauberger B, Hinzen C, Skylaki S, Theodorou M, Kieslinger M, Lemischka I, Moore K and Schroeder T (2016)
external pageIdentification of factors promoting ex vivo maintenance of hematopoietic stem cells by long-term single-cell quantification
Blood, 128:1181-92

Skylaki S, Hilsenbeck O and Schroeder T (2016)
external pageChallenges in long-term imaging and quantification of single cell dynamics
Nature Biotechnology, 34: 1137-1144

Hastreiter S and Schroeder T (2016)
external pageNanog dynamics in single embryonic stem cells
Cell Cycle, 15: 770-771

Kokkaliaris KD*, Lucas D*, Beerman I*, Kent DG, Perié L. (2016)
external pageUnderstanding hematopoiesis from a single-cell standpoint
Exp Hematol, 44: 447-450
* equal contribution

Pietras M, Mirantes-Barbeito C, Fong S, Loeffler D, Kovtonyuk LV, Zhang SY, Lakshminarasimhan R, Chin CP, Techner J-M, Will B, Nerlov C, Steidl U, Manz MG, Schroeder T, Passegué E. (2016)
external pageInterleukin-1 drives hematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal
Nature Cell Biology, 18: 607-618

Gascón S, Murenu E, Masserdotti G, Ortega F, Russo GL, Petrik D, Deshpande A, Heinrich C, Karow M, Robertson SP, Schroeder T, Beckers J, Irmler M, Berndt C, Angeli JP, Conrad M, Berninger B, Götz M. (2016)
external pageIdentification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming
Cell Stem Cell, 18: 396-409

Canli Ö, Alankuş YB, Grootjans S, Vegi N, Hültner L, Hoppe PS, Schroeder T, Vandenabeele P, Bornkamm GW and Greten FR (2016)
external pageGlutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors
Blood, 127: 139-148

Fagnocchi L, Cherubini A, Hatsuda H, Fasciani A, Mazzoleni S, Poli V, Berno V, Rossi R, Reinbold R, Endele M, Schroeder T, Rocchigiani M, Szkarłat Z, Oliviero S, Dalton S, Zippo A. (2016)
external pageA Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity
Nature Communications, 7: 11903

Wingert S, Thalheimer FB, Haetscher N, Rehage M, Schroeder T, Rieger MA. (2016)
external pageThe DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival
Stem Cells, 34: 699-710

Birchler A, Berger M, Jäggin V, Lopes T, Etzrodt M, Misun PM, Pena-Francesch M, Schroeder T, Hierlemann A, Frey O. (2016)
external pageSeamless Combination of Fluorescence-Activated Cell Sorting and Hanging-Drop Networks for Individual Handling and Culturing of Stem Cells and Microtissue Spheroids
Analytical Chemistry, 88: 1222-1229

Feigelman J, Ganscha S, Hastreiter S, Schwarzfischer M, Filipczyk A, Schroeder T, Theis FJ, Marr C, Claassen M (2016)
external pageAnalysis of cell lineage trees by exact Bayesian inference identifies negative autoregulation of Nanog in mouse embryonic stem cells.
Cell Systems, 3: 480-490

Dursun E, Endele M, Musumecia A, Failmezger H, Wang SH, Tresch A, Schroeder T and Krug AB (2016)
external pageContinuous single cell imaging reveals sequential steps of plasmacytoid dendritic cell development from common dendritic cell progenitors
Scientific Reports, 6: 37462

Cornwell JA, Hallet JR, Auf der Mauer S, Motazedian A, Schroeder T, Draper JS, Harvey RP and Nordon RE (2016)
external pageQuantifying intrinsic and extrinsic control of single-cell fates in cancer and stem/progenitor cell pedigrees with competing risks analysis
Scientific Reports, 6: 27100

Engert A, and the authors of the EHA Roadmap for European Hematology Research (incl. Schroeder T) (2016)
external pageThe European Hematology Association Roadmap for European Hematology Research: a consensus document
Haematologica, 101: 115-208

Sarroca S, Molina-Martínez P, Aresté C, Etzrodt M, García de Frutos P, Gasa R, Antonell A, Molinuevo JL, Sánchez-Valle R, Saura CA, Lladó A, Sanfeliu C (2016)
external pagePreservation of cell-survival mechanisms by the presenilin-1 K239N mutation may cause its milder clinical phenotype
Neurobiol. Aging, 46:169-79. 

2015

Filipczyk A*, Marr C*, Hastreiter S*, Feigelman J, Schwarzfischer M, Hoppe PS, Loeffler D, Kokkaliaris KD, Endele M, Schauberger B, Hilsenbeck O, Skylaki S, Hasenauer J, Anastassiadis K, Theis FJ* and Schroeder T* (2015)
external pageNetwork plasticity of pluripotency transcription factors in embryonic stem cells
Nature Cell Biology, 17: 1235-1246

Walter D, Lier A, Geiselhart A, Thalheimer F, Huntscha S, Sobotta M, Moehrle B, Brocks D, Bayindir I, Kaschutnig P, Muedder K, Klein C, Jauch A, Schroeder T, Geiger H, Dick T, Holland-Letz T, Schmezer P, Lane SW, Rieger MA, Essers MAG, Williams DA, Trumpp A and Milsom MD (2015)
external pageExit from dormancy provokes de novo DNA damage-induced cellular attrition in haematopoietic stem cells
Nature, 520: 549-552

Haas S, Hanson U, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast AM, Schnell A, Hexel K, Santarella-Mellwig R, Blaszkiewicz S, Kuck A, Geiger H, Milsom MD, Steinmetz LM, Schroeder T, Trumpp A, Krijgsveld J, Essers MAG (2015)
external pageInflammation-induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors
Cell Stem Cell, 17: 422-434

Mende N, Kuchen EE, Lesche M, Grinenko T, Kokkaliaris KD, Hanenberg H, Lindemann D, Dahl A, Platz A, Höfer T, Calegari F, Waskow C. (2015)
external pageCCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo.
J Exp Med, 212: 1171-1183

Rabenhorst U, Thalheimer FB, Gerlach K, Kijonka M, Böhm S, Krause D, Vauti F, Arnold HH, Schroeder T, Schnütgen F, von Melchner H, Rieger MA, Zörnig M (2015)
external pageSingle-stranded DNA-binding transcriptional regulator FUBP1 is essential for fetal and adult hematopoietic stem cell self-renewal
Cell Reports, 11: 1847-1855

Haetscher N, Feuermann Y, Wingert S, Rehage M, Thalheimer F, Weiser C, Bohnenberger H, Jung K, Schroeder T, Serve H, Oellerich T, Hennighausen L and Rieger MA (2015)
external pageSTAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling
Nature Communications, 6: 8928

Sekhavati F, Endele M, Rappl S, Marel AK, Schroeder T, Rädler JO (2015)
external pageMarker-Free Detection of Progenitor Cell Differentiation by Analysis of Brownian Motion in Micro-Wells
Integrative Biology, 7: 178-183

Yilmaz A, Engeler R, Constantinescu S, Kokkaliaris KD, Dimitrakopoulos C, Schroeder T, Beerenwinkel N and Paro R (2015)
external pageEctopic expression of Msx2 in mammalian myotubes recapitulates aspects of amphibian muscle dedifferentiation.
Stem Cell Research, 15: 542-553

Chantzoura E, Skylaki S, Menendez S, Kim SI, Johnsson A, Linnarsson S, Woltjen K, Chambers I, Kaji K. (2015)
external pageReprogramming Roadblocks Are System Dependent.
Stem Cell Reports, 5: 350-364

Niederberger T, Failmezger H, Uskat D, Poron D, Glauche I, Scherf N, Roeder I, Schroeder T and Tresch A (2015)
external pageFactor graph analysis of live cell imaging data reveals mechanisms of cell fate decisions
Bioinformatics, 31: 1816-1823

Sykes SM*, Kokkaliaris KD*, Milsom MD*, Levine RL, Majeti R. (2015)
external pageClonal evolution of pre-leukemic hematopoietic stem cells in acute myeloid leukemia.
Experimental Hematology, 43: 989-992

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2014


Etzrodt M, Endele M and Schroeder T (2014)
external pageQuantitative single-cell approaches to stem cell research
Cell Stem Cell, 15: 546-558

Hoppe PS, Coutu DL, Schroeder T (2014)
external pageSingle-cell technologies sharpen up mammalian stem cell research
Nature Cell Biology, 16: 919-927

Endele M, Etzrodt M and Schroeder T (2014)
external pageInstruction of hematopoietic lineage choice by cytokine signaling
Experimental Cell Research, 329: 207-213

Coutu DL, Mahfouz W, Loutochin O, Galipeau J, Corcos J (2014)
external pageTissue engineering of rat bladder using marrow-derived mesenchymal stem cells and bladder acellular matrix.
PLoS One, 9: e111966

Claussnitzer M, Dankel SN, Klocke B, Grallert H, Glunk V, Berulava T, Lee H, Oskolkov N, Fadista J, Ehlers K, Wahl S, Hoffmann C, Qian K, Rönn T, Riess H, Müller-Nurasyid M, Bretschneider N, Schroeder T, Skurk T, Horsthemke B, DIAGRAM+ Consortium, Spieler D, Klingenspor M, Seifert M, Kern MJ, Mejhert N, Dahlman I, Hansson O, Hauck SM, Blüher M, Arner P, Groop L, Illig T, Suhre K, Hsu YH, Mellgren G, Hauner H and Laumen H (2014)
external pageLeveraging cross-species transcription factor binding site patterns: from diabetes risk Loci to disease mechanisms.
Cell, 156: 343-358

Tanaka Y, Sanchez V, Takata N, Yokomizo T, Yamanaka Y, Kataoka H, Hoppe PS, Schroeder T and Nishikawa SI (2014)
external pageCirculation-Independent Differentiation Pathway from Extraembryonic Mesoderm toward Hematopoietic Stem Cells via Hemogenic Angioblasts
Cell Reports, 8: 31-39

Hasemann MS, Lauridsen FKB, Waage J, Jakobsen JS, Frank AK, Schuster MB, Rapin N, Bagger FO, Hoppe PS, Schroeder T and Porse BT (2014)
external pageC/EBPα Is Required for Long-Term Self-Renewal and Lineage Priming of Hematopoietic Stem Cells and for the Maintenance of Epigenetic Configurations in Multipotent Progenitors
PLoS Genetics, 10: e1004079

Thalheimer FB, Wingert S, De Giacomo P, Haetscher N, Rehage M, Brill B, Theis F, Hennighausen L, Schroeder T, Rieger MA (2014)
external pageCytokine-regulated Gadd45γ induces differentiation and lineage selection in hematopoietic stem cells
Stem Cell Reports, 3: 34-43

Khakhutskyy V, Schwarzfischer M, Hubig N, Plant C, Marr C, Rieger MA, Schroeder T and Theis FJ (2014)
external pageCentroid clustering of cellular lineage trees
Lecture Notes in Computer Science, 8649: 15-29

Pertek A, Meier F, Irmler M, Beckers J, Skylaki S, Endele M, Wurst W, Prakash N, Kühn R. (2014)
external pageSimple Derivation of Transgene-Free iPS Cells by a Dual Recombinase Approach.
Molecular Biotechnology, 56: 697-713

Cabrera CM, Tilahun E, Nakles R, Diaz-Cruz ES, Charabaty A, Suy S, Jackson P, Ley L, Slack R, Jha R, Collins SP, Haddad N, Kallakury BVS, Schroeder T, Pishvaian MJ, and Furth P (2014)
external pageHuman pancreatic cancer-associated stellate cells remain activated after in vivo chemoradiation
Frontiers in Oncology, 4: 102

Araújo GLL, Araújo JAM, Schroeder T, Tort ABL, Costa MR (2014)
external pageSonic hedgehog signaling regulates mode of cell division of early cerebral cortex progenitors and increases astrogliogenesis
Frontiers in Neuroscience, 8: 77

Coutu DL* and Galipeau J. (2014) *corresponding author
Molecular and endocrine mechanisms underlying the stem cell theory of aging.
Adult stem cells (K.Turksen ed.), pp.389-417

Trompouki E, King KY, Will B, Lessard J, Flores-Figueroa E, Kokkaliaris KD, Bowman T (2014)
external pageBloody signals: From birth to disease and death.
Experimental Hematology, 42: 989-994

Tsakiridis A, Huang Y, Blin G, Skylaki S, Wymeersch F, Osorno R, Economou C, Karagianni E, Zhao S, Lowell S and Wilson V (2014)
external pageDistinct Wnt-driven primitive streak-like populations reflect in vivo lineage precursors.
Development, 141: 1209-1221

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2013


Filipczyk A, Gkatzis K, Fu J, Hoppe PS, Lickert H, Anastassiadis K and Schroeder T (2013)
external pageBiallelic expression of nanog protein in mouse embryonic stem cells
Cell Stem Cell, 13: 12-31

Coutu DL and Schroeder T (2013)
external pageProbing cellular processes by long-term live imaging – historic problems and current solutions
Journal of Cell Science, 126: 3805-3815

Schroeder T (2013)
external pageHeterogeneity of sister cell fates
Nature Reviews Molecular Cell Biology, 14: 327

O’Malley J, Skylaki S, Iwabuchi KA, Chantzoura E, Ruetz T, Johnsson A, Tomlinson SR, Linnarsson S and Kaji K (2013)
external pageHigh resolution analysis with novel cell-surface markers identifies routes to iPS cells
Nature, 499: 88-91

Ortega F, Gascón S, Masserdotti G, Deshpande A, Simon C, Fischer J, Dimou L, Lie DC, Schroeder T and Berninger B (2013)
external pageOligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling
Nature Cell Biology, 15: 602-613

Rengstl B, Newrzela S, Heinrich T, Weiser C, Thalheimer FB, Schmid F, Warner K, Hartmann S, Schroeder T, Küppers R, Rieger MA and Hansmann ML (2013)
external pageIncomplete cytokinesis and re-fusion of small mononucleated Hodgkin cells lead to giant multinucleated Reed-Sternberg cells
PNAS, 110: 20729-20734

Swiers G, Baumann C, O’Rourke J, Giannoulatou E, Taylor S, Joshi A, Moignard V, Pina C, Bee T, Kokkaliaris KD, Yoshimoto M, Yoder M, Frampton J, Schroeder T, Enver T, Gottgens B and de Bruijn MFTR (2013)
external pageEarly dynamic fate changes in haemogenic endothelium characterised at the single cell level
Nature Communications, 4:2924

Müller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger KM, Hembree J, Heppner KM, Hofmann S, Holland J, Küchler D, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch AK, Schriever SC, Speakman J, Tseng YH, Diaz-Meco M, Pfluger PT, Moscat J and Tschöp MH. (2013)
external pagep62 links β-adrenergic input to mitochondrial function and thermogenesis.
J Clin Invest, 123: 469-478

Montrone C, Kokkaliaris KD, Loeffler D, Lechner M, Kastenmüller G, Schroeder T and Ruepp A (2013)
external pageHSC-Explorer: a curated database for hematopoietic stem cells
PLoS One, 8: e70348

Buggenthin F, Marr C, Schwarzfischer M, Hoppe PS, Hilsenbeck O, Schroeder T and Theis FJ (2013)
external pageAn automatic pipeline for robust cell detection in bright field images of high-throughput microscopy
BMC Bioinformatics, 14: 297

Nakles RE, Millman S, Cabrera MC, Johnson P, Mueller S, Hoppe PS, Schroeder T and Furth PA (2013)
external pageTime-lapse Imaging of Primary Preneoplastic Mammary Epithelial Cells Derived from Genetically Engineered Mouse Models of Breast Cancer
J Vis Exp, 72: e50198

Gewies A, Castineiras-Vilarino M, Ferch U, Jährling N, Heinrich K, Hoeckendorf U, Przemeck GKH, Munding M, Gross O, Schroeder T, Horsch M, Karran EL, Majid A, Antonowicz S, Beckers J, Hrabé de Angelis M, Dodt HU, Peschel C, Foerster I, Dyer MJS and Ruland J (2013)
external pagePrdm6 Is Essential for Cardiovascular Development In Vivo
PLoS ONE, 8: e81833

Despars G, Carbonneau CL, Bardeau P, Coutu DL and Beauséjour CM (2013)
external pageLoss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53
PLoS One, 8: e73206

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2012


Rieger MA and Schroeder T (2012)
Hematopoiesis
Cold Spring Harb Perspect Biol, 4
and book: Mammalian Development: Networks, Switches, and Morphogenetic Processes
Cold Spring Harbor Laboratory Press, edited by Nelson, Rossant and Tam

Chambers I and Schroeder T (2012)
external pageStem cell powwow in Squaw Valley
Development, 139: 2457-2461

Endele M and Schroeder T (2012)
external pageMolecular live cell bioimaging in stem cell research
Hematopoietic Stem Cells VIII
Annals of the New York Academy of Sciences, 1266: 18-27

Kokkaliaris KD, Loeffler D and Schroeder T (2012)
external pageAdvances in tracking Hematopoiesis at the single-cell level
Current Opinion in Hematology, 19: 243-249

Marr C, Strasser M, Schwarzfischer M, Schroeder T and Theis FJ (2012)
external pageMulti-scale modeling of GMP differentiation based on single-cell genealogies
FEBS Journal, 279: 3488-3500

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2011


Schroeder T (2011)
external pageLong-term single-cell imaging of mammalian stem cells
Nature Methods, 8: S30-35

Loeffler D, Kokkaliaris KD and Schroeder T (2011)
external pageWnt to notch relay signaling induces definitive hematopoiesis
Cell Stem Cell, 9: 2-4

Warlich E, Kühle J, Cantz T, Brugman M, Maetzig T, Galla M, Filipczyk AA, Foerster R, Klump H, Schöler HR, Baum C, Schroeder T* and Schambach A* (2011) * corresponding author
external pageLentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming
Molecular Therapy, 19: 782-789

Nordon RE, Ko KH, Odell R and Schroeder T (2011)
external pageMulti-type branching models to describe cell differentiation programs
Journal of Theoretical Biology, 277: 7-18

Eilken HM, Rieger MA, Hoppe PS, Hermann AC, Smejkal BM, Drew EC, Thum M, Ninkovic J, Beckervordersandforth RM and Schroeder T (2011)
external pageContinuous long-term detection of live cell surface markers by ‘in culture’ antibody staining
Protocols Exchange, DOI: 10.1038/protex.2011.205

Heinrich C, Gascón S, Masserdotti G, Lepier A, Sánchez R, Simon-Ebert T, Schroeder T, Götz M and Berninger B (2011)
external pageGeneration of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex
Nature Protocols, 6: 214-228

Ortega F, Costa MR, Simon-Ebert T, Schroeder T, Götz M and Berninger B (2011)
external pageUsing an adherent cell culture of the mouse subependymal zone to study the behavior of adult neural stem cells on a single-cell level
Nature Protocols, 6: 1847-1859

Costa M, Ortega F, Brill M, Beckervordersandforth-Bonk R, Petrone C, Schroeder T, Götz M and Berninger B (2011)
external pageContinuous live imaging of adult neural stem cell division and lineage progression in vitro
Development, 138: 1057-1068

Asami M, Pilz G, Ninkovic J, Godinho L, Schroeder T, Huttner W and Götz M (2011)
external pageThe role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex
Development, 138: 5067-5078

Krumsiek J, Marr C, Schroeder T and Theis FJ (2011)
external pageHierarchical differentiation of myeloid progenitors is encoded in the regulatory logic of the transcription factor network
PLoS One, 6: e22649

Tonge PD, Shigeta M, Schroeder T, Andrews PW (2011)
external pageFunctionally Defined Substates within the Human Embryonic Stem Cell Compartment
Stem Cell Research, 7:145-153

Roeder I, Loeffler M, Glauche I, Bornhaeuser M, Buske P, Clarke G, Cross M, Efroni S, Ilan B, Essers M, Galle J, Giangreco A, Glauche I, Griessinger E, Hoppe P, Kobel S, Krinner A, Lauffenburger D, Lemischka I, LoCelso C, Loeffler M, Lutolf M, Moore K, Nazareth E, Oostendorp R, Palmer M, Pompe T, Rocheteau P, Roeder I, Scherf N, Schroeder T, Tajbakhsh S, Vilne B, van der Wath R, Waskow C, Werner C, Yaromina A, Zandstra P (2011)
external pageTowards a quantitative understanding of stem cell–niche interaction: Experiments, models, and technologies
Blood Cells, Molecules, and Diseases, 46: 308-317

Schwarzfischer M, Marr C, Krumsiek J, Hoppe PS, Schroeder T and Theis FJ (2011)
Efficient fluorescent image normalization for time lapse movies
Proc. Microscopic Image Analysis with Applications in Biology, Heidelberg, Germany, 2. Sept. 2011

Coutu, D.L. & Galipeau, J. (2011)
external pageRoles of FGF signaling in stem cell self-renewal, senescence and aging
Aging, 3: 920-933

  • Nature Technology Feature on Single Cell Analysis highlighting our approaches:
    Schubert C (2011)
    The deepest differences
    Nature, 480: 133 - 137
  • Nature Jobs Feature on Single Cell Imaging highlighting our facility:
    Maxmen A (2011)
    Single-cell analysis: Imaging is everything
    Nature, 480: 139 - 141

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2010


Schroeder T (2010)
external pageHematopoietic stem cell heterogeneity: Subtypes, not unpredictable behavior
Cell Stem Cell, 6: 203-207

Schroeder T (2010)
external pageThe electronic crystal ball: Predicting cell fate from time lapse data
Nature Methods, 7: 190–191

Ninkovic J, Pinto L, Petricca S, Rieger MA, Schroeder T, Ashery-Padan R, Favor J and Götz M (2010)
external pageThe transcription factor Pax6 regulates survival of dopaminergic olfactory bulb neurons via crystallin alpha
Neuron, 68: 682-694

Heinrich C, Blum R, Gascon S, Masserdotti G, Tripathi P, Sánchez R, Tiedt S, Schroeder T, Götz M and Berninger B (2010)
external pageDirecting Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons
PLoS Biology, 8: e1000373

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2009

Rieger MA, Hoppe PS, Smejkal BM, Eitelhuber AC and Schroeder T (2009)
external pageHematopoietic cytokines can instruct lineage choice
Science, 325: 217 - 218


Eilken HM, Nishikawa SI and Schroeder T (2009)
external pageContinuous single-cell imaging of blood generation from haemogenic endothelium
Nature, 457: 896 - 900


Kimura A*, Rieger MA*, Simone JM, Chen W, Wickre MC, Zhu BM, Hoppe PS, O’Shea J, Schroeder T** and Hennighausen L** (2009)
* and ** equal contributions
external pageThe transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis
Blood, 114: 4721 - 4728

Rieger MA and Schroeder T (2009)
external pageAnalysing cell fate control by cytokines through continuous single cell biochemistry
Journal of Cellular Biochemistry, 108: 343 - 352

Rieger MA, Smejkal BM and Schroeder T (2009)
external pageImproved prospective identification of megakaryocyte-erythrocyte progenitor cells
British Journal of Haematology, 144: 448 - 451

Rieger MA and Schroeder T (2009)
external pageInstruction of lineage choice by hematopoietic cytokines
Cell Cycle, 8: 4019 - 4020

Costa M, Bucholz O, Schroeder T and Götz M (2009)
external pageLate origin of glia-restricted progenitors in the developing mouse cerebral cortex
Cerebral Cortex, 19 Suppl 1: i135 - 143

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2008


Schroeder T (2008)
external pageImaging stem cell driven mammalian regeneration
Nature, 453: 345 - 351

Rieger MA and Schroeder (2008)
external pageExploring hematopoiesis at single cell resolution
Cells Tissues Organs, 188: 139-149

Henning K*, Heering J*, Schwanbeck R*, Schroeder T*, Helmbold H, Schäfer H, Deppert W, Kim E and Just U (2008) * equal contribution
external pageNotch1 activation reduces proliferation in multipotent hematopoietic progenitor cell line FDCP-mix through a p53-dependent pathway but Notch1 effects on myeloid and erythroid differentiation are independent of p53
Cell Death and Differentiation, 15: 398-407

Drew EC and Schroeder T (2008)
The Big Brother of Blood: The need for constant video surveillance of individual cells
New Cell Differentiation Research Topics, edited by H Saitama
Nova Science Publishers, 229 - 246

Costa M, Wen G, Lepier A, Schroeder T and Götz M (2008)
external pagePar complex proteins promote proliferating progenitor divisions in the developing mouse cerebral cortex
Development, 135: 11-22

Schwanbeck R, Schroeder T, Henning K, Kohlhof H, Rieber N, Erfurth ML and Just U (2008)
external pageNotch signalling in embryonic and adult hematopoiesis
Cells Tissues Organs, 188: 91-102

Rastelli J, Hömig C, Seagal J, Müller W, Hermann A, Rajewsky K and Zimber-Strobl U (2008)
external pageLMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switsh recombination to IgG1
Blood, 111: 1448-1455

Klier M, Anastasov N, Hermann A, Meindl T, Angermeier D, Raffeld M, Fend F and Quintanilla-Martinez L (2008)
external pageSpecific lentiviral shRNA-mediated knockdown of cyclin D1 in mantle cell lymphoma has minimal effects on cell survival and reveals a regulatory circuit with cyclin D2
Leukemia, 22: 2097-2105

Arakawa H, Kudo H, Batrak V, Caldwell RB, Rieger MA, Ellwart JW and Buerstedde JM (2008)
external pageProtein evolution by hypermutation and selection in the B cell line DT40
Nucleic Acids Research, 36: e1

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2007


Schroeder T (2007)
external pageAsymmetric cell division in normal and malignant hematopoietic precursor cells
Cell Stem Cell, 1: 479-481

Henning K*, Schroeder T*, Schwanbeck R, Rieber N, Bresnick E and Just U (2007) * equal contribution
external pagemNotch1 signaling and erythropoietin cooperate in erythroid differentiation of multipotent progenitor cells and upregulate β-globin
Experimental Hematology, 35: 1321 - 1332

Rieger MA and Schroeder T (2007)
Hämatopoetische Stammzellen
Review (German)
Biospektrum, 3.2007: 254-256

Berninger B, Costa M, Schroeder T, Koch U, Sutor B, Grothe B and Götz M (2007)
external pageFunctional properties of neurons derived from in-vitro reprogrammed postnatal astroglia
The Journal of Neuroscience, 27: 8654 - 8664

Fürst R, Schroeder T, Eilken HM, Bubik M, Kiemer A, Zahler S and Vollmar A (2007)
external pageMKP-1 represents a novel anti-inflammatory target of glucocorticoids in the human endothelium
FASEB Journal, 21: 74-80

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2006


Schroeder T*, Meier-Stiegen F, Schwanbeck R, Eilken H, Nishikawa S, Häsler R, Schreiber S, Bornkamm GW, Nishikawa SI and Just U* (2006) * corresponding author
external pageActivated Notch1 alters differentiation of embryonic stem cells into mesodermal cell lineages at multiple stages of development
Mechanisms of Development, 123: 570-579

Cappello S, Attardo A, Wu X, Iwasato T, Itohara S, Wilsch-Brauninger M, Eilken HM, Rieger MA, Schroeder T, HuttnerWB, Brakebusch C and Götz M (2006)
external pageThe Rho-GTPase cdc42 regulates cortical progenitor fate at the apical surface
Nature Neuroscience, 9: 1099-1107

Yurugi –Kobayashi Y, Itoh H, Schroeder T, Nakano A, Narazaki G, Kita F, Yanagi K, Hiraoka-Kanie M, Inoue E, Ara T, Nagasawa T, Just U, Nakao K, Nishikawa SI and Yamashita J (2006)
external pageAdrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors
Arteriosclerosis, Thrombosis, and Vascular Biology, 26: 1977-1984

Wolff H, Hartl A, Eilken HM, Hadian K, Ziegler M and Brack-Werner R (2006)
external pageA live-cell assay for simultaneous monitoring of expression and interaction of proteins
Biotechniques, 41: 688-692

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2005


Schroeder T. (2005)
external pageTracking Hematopoiesis at the Single Cell Level.
Hematopoietic Stem Cells V,
Annals of the New York Academy of Sciences, 1044: 201-209

Czuchra A., Wu X., Meyer H., van Hengel J., Schroeder T., Rottner K. and Brakebusch C. (2005)
external pageCdc42 is not essential for filopodium formation, directed migration, cell polarization and mitosis in fibroblastoid cells
Molecular Biology of the Cell, 16: 4473-4484

Mayer R., Brero A., von Hase J., Schroeder T., Cremer T. and Dietzel S. (2005)
external pageCommon Themes and Cell Type Specific Variations of Higher Order Chromatin Arrangements in the Mouse
BMC Cell Biol, 6: 44

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2004


Okita C., Sato M. and Schroeder T. (2004)
external pageGeneration of optimized yellow and red fluorescent proteins with distinct subcellular localization.
Biotechniques, 36: 418-423

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2003


Schroeder T. , Fraser S., Ogawa M., Nishikawa S., Oka C., Bornkamm GW., Nishikawa SI., Honjo T. and Just U. (2003)
external pageRecombination signal sequence-binding protein Jk alters mesodermal cell fate decisions by suppressing cardiomyogenesis.
PNAS, 100: 4018-4023

Schroeder T. , Kohlhof H., Rieber N. and Just U. (2003)
external pageNotch signaling induces multilineage myeloid differentiation and up-regulates PU.1 expression.
The Journal of Immunology, 170: 5538-5548

McIvor Z., Hein S., Fiegler H., Schroeder T., Stocking C., Just U. and Cross M. (2003)
external pageTransient expression of PU.1 commits multipotent progenitors to a myeloid fate whereas continued expression favors macrophage over granulocyte differentiation.
Experimental Hematology, 31: 39-47

Mathys S., Schroeder T., Ellwart J., Koszinowski U. , Messerle M. and Just U. (2003)
external pageDendritic cells under influence of mouse cytomegalovirus have a physiologic dual role: to initiate and to restrict T cell activation.
The Journal of Infectious Diseases, 187: 988-999

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2000


Schroeder, T. and Just, U. (2000)
external pageNotch signalling via RBP-J promotes myeloid differentiation.
EMBO Journal, 19: 2558-2568

Schroeder, T. and Just, U. (2000)
external pagemNotch1 signaling reduces proliferation of myeloid progenitor cells by altering cell-cycle kinetics.
Experimental Hematology, 28: 1206-1213

Schroeder, T. , Lange, C., Strehl, J. and Just, U. (2000)
external pageGeneration of functionally mature dendritic cells from the multipotential stem cell line FDCP-mix.
British Journal of Haematology, 111: 890-897

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1999


Drzeniek, Z., Stocker, G., Siebertz, B., Just, U., Schroeder, T., Ostertag, W. and Haubeck, H.D. (1999)
external pageHeparan sulfate proteoglycan expression is induced during early erythroid differentiation of multipotent hematopoietic stem cells.
Blood, 93: 2884-2897

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