In Silico Organogenesis
We use image-based modeling to generate 4D models of organogenesis. Here, we focus in particular on lung, kidney, and CNS development.
Lung, Kidney & Pancreas Development
How are reliable symmetry breaks achieved during branching morphogenesis? And how are developmental processes coordinated such that functional units emerge, i.e. the branching of the ureteric tree with the formation of nephrons to achieve efficient drainage? What are the relative contributions of chemical signalling and tissue mechanics?
Tracheal Ring Formation
Dagmar Iber and Malte Mederacke
external pageFrontiers in Cell and Developmental Biology, 2022.
Editorial: Branching Morphogenesis During Embryonic Lung Development
Elie El Agha, Dagmar Iber and David Warburton
external pageFrontiers in Cell and Developmental Biology, 2021.
Organ-Specific Branching Morphogenesis
Christine Michaela Lang, Lisa Conrad and Dagmar Iber
external pageFrontiers in Cell and Developmental Biology, 2021.
The control of lung branching morphogenesis
Dagmar Iber
external pageCellular Networks in Development, edited by Affolter, Markus, 2021.
Image-Based In silico Models of Organogenesis
Harold F. Gomez, Lada Georgieva, Odyssé Michos and Dagmar Iber
external pageSystems Biology, edited by Nielsen, Jens and Hohmann, Stefan, 2017.
Image-based modelling of organogenesis
Dagmar Iber, Zahra Karimaddini and Erkan Ünal
external pageBriefings in Bioinformatics, 2016.
The control of branching morphogenesis
Dagmar Iber, Denis Menshykau
external pageOpen Biology, 2013.
Geometric Effects Position Renal Vesicles During Kidney Development
Malte Mederacke, Lisa Conrad, Nikoloas Doumpas, Roman Vetter, Dagmar Iber
external pageCell Reports (2023) external pageTweetorial
FGF8 induces chemokinesis and regulates condensation of mouse nephron progenitor cells
Abhishek Sharma, Marco Meer, Arvydas Dapkunas, Anneliis Ihermann-Hella, Satu Kuure, Seppo Vainio, Dagmar Iber and Florence Naillat
external pageDevelopment (2022), external pageTeaser, external pageTweetorial
Identification and implication of tissue-enriched ligands in epithelial-endothelial crosstalk during pancreas development
Moulis et al.
external pageScientific Reports (2022)
Development of a 3D atlas of the embryonic pancreas for topological and quantitative analysis of heterologous cell interactions
Glorieux et al.
external pageDevelopment (2022)
The biomechanical basis of biased epithelial tube elongation in lung and kidney development
Lisa Conrad, Steve Runser, Harold F. Gómez, Christine Michaela Lang, Mathilde Sabine Dumond, Aleksandra Sapala, Laura Schaumann, Odyssé Michos, Roman Vetter and Dagmar Iber
external pageDevelopment (2021) external pageTeaser external pageInterview external pageTweetorial
Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback
Denis Menshykau, Odyssé Michos, Christine Lang, Lisa Conrad, Andrew P. McMahon and Dagmar Iber
external pageNature Communications, 2019.
Feedback, receptor clustering, and receptor restriction to single cells yield large Turing spaces for ligand-receptor-based Turing models
Tamás Kurics, Denis Menshykau, Dagmar Iber
external pagePhys Rev E Stat Nonlin Soft Matter Phys, 2014
An interplay of geometry and signaling enables robust lung branching morphogenesis
Menshykau M, Blanc P, Unal E, Sapin V and Iber D
external pageDevelopment, 2014.
Simulations demonstrate a simple network to be sufficient to control branch point selection, smooth muscle and vasculature formation during lung branching morphogenesis
Géraldine Cellière, Denis Menshykau, Dagmar Iber
external pageBiol Open (2012)
Branch Mode Selection during Early Lung Development
Denis Menshykau, Conradin Kraemer, Dagmar Iber
external pagePlos Comp Biol (2012)
The protooncogene Ski regulates the neuron-glia switch during development of the mammalian cerebral cortex
Grison A, Karimaddini Z, Breda J, Mukhtar T, Boareto M, Eschbach K, Beisel C, Iber D, van Nimwegen E, Verdon Taylor, Atanasoski S
external pagebioRxiv, 2022
Hingepoint emergence in mammalian spinal neurulation.
de Goederen V, Vetter R, McDole K, Iber D
external pagebioRxiv (2021) external pageTweetorial
A Shh/Gli-driven three-node timer motif controls temporal identity and fate of neural stem cells
Dias JM, Alekseenko Z, Jeggari A, Boareto M, Vollmer J, Kozhevnikova M, Wang H, Matise MP, Alexeyenko A, Iber D, Ericson J
external pageScience Advances, 2020.
Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis
Mukhtar T, Breda J, Boareto M, Grobecker P, Karimaddini Z, Grison A, Eschbach K, Chandrasekhar R, Vermeul S, Okoniewski M, Pachkov M, Atanasoski S, Beisel C, Iber D, van Nimwegen E, Verdon Taylor
external pageThe EMBO Journal 2022 e111132
Tead transcription factors differentially regulate cortical development
Tanzila Mukhtar, Jeremie Breda, Alice Grison, Zahra Karimaddini, Pascal Grobecker, Dagmar Iber, Christian Beisel, Erik van Nimwegen and Verdon Taylor
external pageScientific Reports, 2020.
Id4 Downstream of Notch2 Maintains Neural Stem Cell Quiescence in the Adult Hippocampus
Zhang R, Boareto M, Engler A, Louvi A, Giachino C, Iber D and Taylor V
external pageCell Reports, 2019.
Differential interactions between Notch and ID factors control neurogenesis by modulating Hes factor autoregulation
Marcelo Boareto, Dagmar Iber and Verdon Taylor
external pageDevelopment, 2017.