Fundamental Mechanisms
We are interested in the basic biological principles that enable a multicellular organism to develop and to evolve.
Patterning Mechanisms
During development cells must assume different fates in a position-dependent manner. Different reaction-diffusion mechanisms have been described that convey the positional information. However, open questions remain: How do patterning mechanisms scale on groing domains? How can boundaries be defined robustly? And how can these mechanisms be both robust, yet evolve?
Morphogen gradients can convey position and time in growing tissues
Roman Vetter, and Dagmar Iber
external pagebioRxiv (2023), external pageTweetorial
2D Effects Enhance Precision of Gradient-Based Tissue Patterning
Yuchong Long, Roman Vetter, and Dagmar Iber
external pageiScience (2023), external pageTweetorial
Patterning precision under non-linear morphogen decay and molecular noise
Jan A. Adelmann, Roman Vetter, and Dagmar Iber
external pageelife (2023), external pageTweetorial, Research Highlight: external pageNat Comp Sci
Impact of cell size on morphogen gradient precision
Jan A. Adelmann, Roman Vetter, and Dagmar Iber
external pageDevelopment (2023), external pageTweetorial, Research Highlight: external pageDevelopment
Precision of morphogen gradients in neural tube development
Roman Vetter, and Dagmar Iber
external pageNat Commun (2022), external pageTweetorial, external pageTweetorial Preprint
Positional information encoded in the dynamic differences between neighboring oscillators during vertebrate segmentation
Marcelo Boareto do Amaral, Tomas Tomka and Dagmar Iber
external pageCells & Development (2021)
Read-Out of Dynamic Morphogen Gradients on Growing Domains
Patrick Fried and Dagmar Iber
external pagePLoS ONE (2015)
Dynamic scaling of morphogen gradients on growing domains
Patrick Fried and Dagmar Iber
external pageNature Communications (2014)
Axis Patterning by BMPs: Cnidarian Network Reveals Evolutionary Constraints
Genikhovich G, Fried P, Prünster MM, Schinko JB , Gilles AF, Fredman D, Meier K, Iber D and Technau U
external pageCell Reports (2015)
The mechanism of sudden stripe formation during dorso-ventral patterning in Drosophila
D Iber, G Gaglia
external pageJournal of mathematical biology (2007)
3D epithelial organisation
Epithelial tissues play a key role in development and disease. We have recently uncovered the physical principle behind the complex 3D cell neighbour relationships in pseudostratified epithelia by combining light-sheet microscopy with theoretical work. Cell neighbour interactions are more numerous and dynamic than previously anticipated, with potentially profound implications for cell communication. external pageTweetorial
3D Cell neighbour dynamics in growing pseudostratified epithelia
Harold F. Gómez, Mathilde S. Dumond, Leonie Hodel, Roman Vetter and Dagmar Iber
external pageeLife (2021) external pageTweetorial
Minimisation of surface energy drives apical epithelial organisation and gives rise to Lewis’ law
Kokic M, Iannini A, Villa-Fombuena G, Casares F and Iber D
external pagebioRxiv (2019)
Aboave-Weaire’s law in epithelia results from an angle constraint in contiguous polygonal lattices
Vetter R, Kokic M, Gómez HF, Hodel L, Gjeta B, Iannini A, Villa-Fombuena G, Casares F and Iber D
external pagebioRxiv (2019)
3D organisation of cells in pseudostratified epithelia
Iber D & Vetter R
external pageFront Phys (2022)
Relationship between epithelial organisation and morphogen interpretation
Iber D & Vetter R
external pageCurr Opinion in Genetics & Development (2022)
Growth and size control during development
Jannik Vollmer, Fernando Casares and Dagmar Iber
external pageOpen Biology (2017)
Growth control in the Drosophila eye disc by the cytokine unpaired
Vollmer J, Fried P, Aguilar-Hidalgo D, Sánchez-Aragón M, Iannini A, Casares F and Iber D
external pageDevelopment (2017)
A quantitative analysis of growth control in the Drosophila eye disc.
Vollmer J, Fried P, Sánchez-Aragón M, Lopes CS, Casares F, Iber D
external pageDevelopment (2016) external pageTeaser
An Unbiased Analysis of Candidate Mechanisms for the Regulation of Drosophila Wing Disc Growth.
Jannik Vollmer and Dagmar Iber
external pageScientific Reports (2016)