New Paper in Nature Communications

In our new paper we find that upon initiating cell adhesion αV-class integrins engaged to the extracellular matrix protein, fibronectin, signal to α5β1 integrins to establish additional adhesion sites and to strengthen cell adhesion. The cooperative crosstalk between both fibronectin-binding integrin classes towards establishing cell adhesion appears to be a basic cellular mechanism. See Bharadwaj et al Nat. Commun.