New Paper in Nature Nanotechnology!

Viral infection is initiated when a virus binds to cell surface receptors. However, the very first binding events of enveloped viruses are hardy understood. Here, we introduce an nanoscopic assay to image animal cells and to detect virus-binding events within the first ms of contact at high resolution. We observe how viruses quickly occupy binding sites of the viral glycoprotein to initiate virus fusion and uptake. See Alsteens et al. Nat. Nanotech. (2016)