Journal Articles

2024

K. Kasuba, A. Buccino, J. Bartram, B. Gaub, F. Fauser, S. Ronchi, S. Kumar, S. Geissler, M. Nava, A. Hierlemann, D. Müller "Mechanical stimulation and electrophysiological monitoring at subcellular resolution reveals differential mechanosensation of neurons within networks", Nature Nanotechnology 2024, in press (DOI: 10.1038/s41565-024-01609-1). external pageOnlinecall_made  

O. Nguyen, P. Misun, A. Hierlemann, C. Lohasz, "A versatile intestine-on-chip system for deciphering the immunopathogenesis of inflammatory bowel disease", Advanced Healthcare Materials 2024, in press (DOI: 10.1002/adhm.202302454). external pageOnlinecall_made

M. Hruska-Plochan, V. Wiersma, K. Betz, I. Mallona, S. Ronchi, Z. Maniecka, E. Hock, E. Tantardini, F. Laferriere, S. Sahadevan, V. Hoop, I. Delvendahl, M. Pérez-Berlanga, B. Gatta, M. Panatta, A. van der Bourg, D. Bohaciakova, P. Sharma, L. De Vos, K. Frontzek, A. Aguzzi,T. Lashley, M. Robinson, T. Karayannis, M. Müller, A. Hierlemann & M. Polymenidou, "A model of human neural networks reveals NPTX2 pathology in ALS and FTLD", Nature 2024, in press (DOI: 10.1038/s41586-024-07042-7). Online

J. Sollier, M. Basler, P. Broz, P. Dittrich, K. Drescher, A. Egli, A. Harms, A. Hierlemann, S. Hiller, C. King, J. McKinney, J. Moran-Gilad, R. Neher, M. Page, S. Panke, A. Persat, P. Picotti, K. Rentsch, P. Rivera-Fuentes, U. Sauer, D. Stolz, S. Tschudin-Sutter, C. van Delden, E. van Nimwegen, J-W. Veening, M. Zampieri, A. Zinkernagel, N. Khanna, D. Bumann, U. Jenal, C. Dehio, "Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions", Nature Microbiology 2024 (DOI: 10.1038/s41564-023-01566-w). external pageOnlinecall_made

2023

P. Hornauer, G. Prack, N. Anastasi, S. Ronchi, T. Kim, C. Donner, M. Fiscella, K. Borgwardt, V. Taylor, R. Jagasia, D. Roqueiro, A. Hierlemann, M. Schröter, "DeePhys: A machine learning–assisted platform for electrophysiological phenotyping of human neuronal networks", Stem Cell Reports 2023 (DOI: 10.1016/j.stemcr.2023.12.008). external pageOnlinecall_made

E. T. Zhao, J. M. Hull, N. M. Hemed, H. Uluşan, J. Bartram, A. Zhang, P. Wang, A. Pham, S. Ronchi, J. R. Huguenard, A. Hierlemann, and N. A. Melosh, "A CMOS-based highly scalable flexible neural electrode interface", Science Advances 2023, 9, Article: eadf9524 (DOI:10.1126/sciadv.adf9524). external pageOnlinecall_made

J. Bartram, F. Franke, S. Kumar, A. Buccino, X. Xue, T. Gänswein, M. Schröter, T. Kim, K. Kasuba, A. Hierlemann, "Parallel reconstruction of the excitatory and inhibitory inputs received by single neurons reveals the synaptic basis of recurrent spiking", eLife 2023, Article 12:RP86820 (DOI: 10.7554/eLife.86820.1). external pageOnlinecall_made 

W. Wei, F. Cardes, A. Hierlemann, M. Modena, "3D in vitro blood-brain-barrier model for investigating barrier insults", Advanced Science 2023, Article 2205752 (DOI: 10.1002/advs.202205752). external pageOnlinecall_made

M. Gazorpak, K.M. Hugentobler, D. Paul, P.-L. Germain, M. Kretschmer, I. Ivanova, S. Frei, K. Mathis, R. Rudolf, S. Mompart Barrenechea, V. Fischer, X. Xue, A. L. Ptaszek, J. Holzinger, M. Privitera, A. Hierlemann, O. C. Meijer, R. Konrat, E. M. Carreira, J. Bohacek and K. Gapp, "Harnessing PROTAC technology to combat stress hormone receptor activation", Nature Communications 2023, 14, 8177 (DOI: 10.1038/s41467-023-44031-2). external pageOnlinecall_made

F. Cardes, E. Azizi, A. Hierlemann, "A time-domain readout technique for neural interfaces based on VCO-timestamping", IEEE Transactions on Biomedical Circuits and Systems 2023, in press (DOI: 10.1109/TBCAS.2023.3274834). external pageOnlinecall_made  

F. Gökçe, A. Kaestli, C. Lohasz, M. de Geus, H.-M. Kaltenbach, K. Renggli, B. Bornhauser, A. Hierlemann, M. Modena, "Microphysiological drug-testing platform for identifying responses to prodrug treatment in primary leukemia", Advanced Healthcare Materials 2023, Article 2202506 (DOI: 10.1002/adhm.202202506). external pageOnlinecall_made

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2022

T. Kim, D. Chen, P. Hornauer, V. Emmenegger, J. Bartram, S. Ronchi, A. Hierlemann, M. Schröter, D. Roqueiro, "Predicting in vitro single-neuron firing rates upon pharmacological perturbation using graph neural networks", Frontiers in Neuroinformatics 2022, Vol. 16, Article 1032538 (DOI: 10.3389/fninf.2022.1032538). external pageOnlinecall_made

J. Lee, T. Gänswein, H. Ulusan, V. Emmenegger, A. Saguner, F. Duru, A. Hierlemann, "Repeated and on-​demand intracellular recordings of cardiomyocytes derived from human-​induced pluripotent stem cells", ACS Sensors 2022, 7 (10), p. 3181–3191 (DOI: 10.1021/acssensors.2c01678). external pageOnlinecall_made

X. Xue, A. P. Buccino, S. Saseendran Kumar, A. Hierlemann, and J. Bartram, "Inferring monosynaptic connections from paired dendritic spine Ca2+ imaging and large-scale recording of extracellular spiking", Journal of Neural Engineering 2022, 19 (4), Article 046044 (DOI: 10.1088/1741-2552/ac8765). external pageOnlinecall_made

R. Castellanos-Rueda, R. Di Roberto, F. Bieberich, F. Schlatter, D. Palianina, O. Nguyen, E. Kapetanovic, H. Läubli, A. Hierlemann, N. Khanna, S. Reddy, "SpeedingCARs: accelerating the engineering of CAR T cells by signaling domain shuffling and single-cell sequencing", Nature Communications 2022, Vol. 13, Article 6555 (DOI: 10.1038/s41467-022-34141-8). external pageOnlinecall_made  

M. Schröter, C. Wang, M. Terrigno, P. Hornauer, Z. Huang, R. Jagasia, A. Hierlemann, "Functional imaging of brain organoids using high-density microelectrode arrays", MRS Bulletin 2022, Vol. 47, p 530–544 (DOI: 10.1557/s43577-022-00282-w). external pageOnlinecall_made

S. Kumar, T. Gänswein, A. Buccino, X. Xue, J. Bartram, V. Emmenegger, A. Hierlemann, "Tracking axon initial segment plasticity using high-density microelectrode arrays: A computational study", Frontiers in Neuroinformatics 2022, Vol. 16, Article 957255 (DOI: 10.3389/fninf.2022.957255). external pageOnlinecall_made

N. Rousset, C. Lohasz, J. A. Boos, P. M. Misun, F. Cardes, and A. Hierlemann, "Circuit-based design of microfluidic drop networks", Micromachines 2022, 13 (7), p. 1124 (DOI: 10.3390/mi13071124). Online

T. Sharf, T. van der Molen, S. Glasauer, E. Guzman, A. Buccino, G. Luna, Z. Cheng, M. Audouard, K. Ranasinghe, K. Kudo, S. Nagarajan, K. Tovar, L. Petzold, A. Hierlemann, P. Hansma, Paul, K. Kosik, "Functional neuronal circuitry and oscillatory dynamics in human brain organoids", Nature Communications 2022, Vol. 13, No. 1, p. 4403, (DOI: 10.1038/s41467-022-32115-4). external pageOnlinecall_made

R. Bounik, F. Cardes, H. Ulusan, M. Modena, A. Hierlemann, "Impedance imaging of cells and tissues: design and applications", BME Frontiers 2022, Article 9857485 (DOI: 10.34133/2022/9857485). external pageOnlinecall_made

B. Yesildag, J. Mir-Coll, A. Neelakandhan, C. B. Gibson, N. R. Perdue, C. Rufer, M. Karsai, A. Biernath, F. Forschler, P. Wu Jin, P. M. Misun, A. Hierlemann, F. F. Kreiner, J. D. Wesley, M. G. von Herrath, "Liraglutide protects β-cells in novel human islet spheroid models of type 1 diabetes", Clinical Immunology 2022, Volume 244, Article 109118 (DOI: 10.1016/j.clim.2022.109118). external pageOnlinecall_made

P. S. Ravaynia, S. Biendl, F. Grassi, J. Keiser, A. Hierlemann, M. M. Modena, "Real-time and automated monitoring of antischistosomal drug activity profiles for screening of compound libraries", iScience 2022, 25 (4), 104087 (DOI: 10.1016/j.isci.2022.104087). external pageOnlinecall_made

A. Buccino, X. Yuan, V. Emmenegger, X. Xue, T. Gänswein, A. Hierlemann, "An automated method for precise axon reconstruction from recordings of high-density micro-electrode arrays", Journal of Neural Engineering 2022, 19 (2), Article 026026 (DOI: /10.1088/1741-2552/ac59a2). external pageOnlinecall_made

V. Sessi, B. Ibarlucea, F. Seichepine, S. Klinghammer, I. Ibrahim, A. Heinzig, N. Szabo, T. Mikolajick, A. Hierlemann, U. Frey, W. Weber, L. Baraban, G. Cuniberti, "Multisite dopamine sensing with femtomolar resolution using a CMOS-enabled aptasensor chip", Frontiers in Neuroscience 2022, Vol. 16, Article 875656 (DOI: 10.3389/fnins.2022.875656). external pageOnlinecall_made

N. Rousset, R. Sandoval, M. Modena, A. Hierlemann, P. Misun, "Modeling and measuring glucose diffusion and consumption by colorectal cancer spheroids in hanging drops using integrated biosensors", Microsystems & Nanoengineering 2022, Vol. 8, Article 14 (DOI: 10.1038/s41378-021-00348-w). external pageOnlinecall_made

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2021

C. Lohasz, J. Loretan, D. Sterker, E. Görlach, K. Renggli, P. Argast, O. Frey, M. Wiesmann, M. Wartmann, M. Rausch, A. Hierlemann, "A microphysiological cell-culturing system for pharmacokinetic drug exposure and high-resolution imaging of arrays of 3D microtissues", Frontiers in Pharmacology 2021,12:785851 (DOI: 10.3389/fphar.2021.785851). external pageOnlinecall_made

J. Boos, P. Misun, G. Brunoldi, L. Furer, L. Aengenheister, M. Modena, N. Rousset, T. Buerki-Thurnherr, Andreas Hierlemann, "Microfluidic co-culture platform to recapitulate the maternal–placental–embryonic axis", Advanced Biology 2021, Article 2100609 (DOI: 10.1002/adbi.202100609). external pageOnlinecall_made

O. T. P. Nguyen, P. M. Misun, C. Lohasz, J. Lee, W. Wang, T. Schroeder, A. Hierlemann, "An immunocompetent microphysiological system to simultaneously investigate effects of anti-tumor natural killer cells on tumor and cardiac microtissues", Frontiers in Immunology 2021, Article 781337 (DOI: 10.3389/fimmu.2021.781337). external pageOnlinecall_made

F. Gökçe, P. S. Ravaynia, M. M. Modena, A. Hierlemann, "What is the future of electrical impedance spectroscopy in flow cytometry?", Biomicrofluidics 2021, 15, 061302 (DOI: 10.1063/5.0073457). external pageOnlinecall_made  

X. Yuan, A. Hierlemann, U. Frey, "Extracellular recording of entire neural networks using a dual-mode microelectrode array with 19,584 electrodes and high SNR", IEEE Journal of Solid-State Circuits 2021, Vol. 56(8), pp. 2466-2475 (DOI: 10.1109/JSSC.2021.3066043). external pageOnlinecall_made

S. Ronchi, A. Buccino, G. Prack, S. Kumar, M. Schröter, M. Fiscella, A. Hierlemann, "Electrophysiological phenotype characterization of human iPSC‐derived neuronal cell lines by means of high‐density microelectrode arrays", Advanced Biology 2021, Article 2000223 (DOI: 10.1002/adbi.202000223). external pageOnlinecall_made

F. Cardes, N. Baladari, J. Lee, A. Hierlemann, "A Low-power opamp-less second-order delta-sigma modulator for bioelectrical signals in 0.18 µm CMOS", Sensors 2021, 21, 6456 (DOI: 10.3390/s21196456). external pageOnlinecall_made

I. El-Battrawy, H. Lan, L. Cyganek, L. Maywald, R. Zhong, F. Zhang, Q. Xu, J. Lee, E. Duperrex, A. Hierlemann, A. Saguner, F. Duru, B. Kovacs, M. Huang, Z. Liao, S. Albers, J. Müller, H. Dinkel, L. Rose, A. Hohn, Z. Yang, L. Qiao, Y. Li, S. Lang, M. Kleinsorge, A. Mügge, A. Aweimer, X. Fan, S. Diecke, I. Akin, G. Li, X. Zhou, "Deciphering the pathogenic role of a variant with uncertain significance for short QT and Brugada syndromes using gene-edited human-induced pluripotent stem cell-derived cardiomyocytes and preclinical drug screening", Clinical and Translational Medicine 2021, 11: e646 (DOI: 10.1002/ctm2.646). external pageOnlinecall_made

P. Jin, N. Rousset, A. Hierlemann, P. Misun, "A microfluidic hanging-drop-based islet perifusion system for studying glucose-stimulated insulin secretion from multiple individual pancreatic islets", Frontiers in Bioengineering and Biotechnology 2021, Vol. 9, pp. 352 (DOI: 10.3389/fbioe.2021.674431). external pageOnlinecall_made  

Z. Zhu, Y. Wang, R. Peng, P. Chen, Y. Geng, B. He, S. Ouyang, K.Zheng, Y. Fan, D. Pan, N. Jin, F. Rudolf, A. Hierlemann, "A microfluidic single-cell array for in situ laminar-flow-based comparative culturing of budding yeast cells", Talanta 2021, Volume 231, 122401 (DOI: 10.1016/j.talanta.2021.122401). external pageOnlinecall_made

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2020

X. Yuan, M. Schröter, M. Engelene J. Obien, M. Fiscella, W. Gong, T. Kikuchi, A. Odawara, S. Noji, I. Suzuki, J. Takahashi, A. Hierlemann, U. Frey, "Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level", Nature Communications 2020, 11, 4854 (DOI: 10.1038/s41467-020-18620-4). external pageOnlinecall_made

C. Lohasz, F. Bonanini, L. Hoelting, K. Renggli, O. Frey, A. Hierlemann, "Predicting metabolism‐related drug–drug interactions using a microphysiological multitissue system", Advanced Biosystems 2020, Article 2000079 (DOI: 10.1002/adbi.202000079). external pageOnlinecall_made

P. S. Ravaynia, F. C. Lombardo, S. Biendl, M. A. Dupuch, J. Keiser, A. Hierlemann, M. M. Modena, "Parallelized impedance‐based platform for continuous dose‐response characterization of antischistosomal drugs", Advanced Biosystems 2020, Article 1900304 (DOI: 10.1002/adbi.201900304). external pageOnlinecall_made

F. Lombardo, P. Ravaynia, M. Modena, A. Hierlemann, and J. Keiser, "Evaluation of human liver microtissues for drug screening on schistosoma mansoni schistosomula", ACS Infectious Diseases 2020, in press (DOI: 10.1021/acsinfecdis.0c00614). external pageOnlinecall_made

C. Cowan, M. Renner, M. De Gennaro, B. Gross-Scherf, D. Goldblum, Y. Hou, M. Munz, T. Rodrigues, J. Krol, T. Szikra, R. Cuttat, A. Waldt, P. Papasaikas, R. Diggelmann, C. P. Patino-Alvarez, P. Galliker, S. E. Spirig, D. Pavlinic, N. Gerber-Hollbach, S. Schuierer, A. Srdanovic, M. Balogh, R. Panero, A. Kusnyerik, A. Szabo, M. Stadler, S. Orgül, S. Picelli, P. Hasler, A. Hierlemann, H. Scholl, G. Roma, F. Nigsch, B. Roska, "Cell types of the human retina and its organoids at single-cell resolution", Cell 2020, Vol. 182(6), pp. 1623-1640.e34 (DOI: 10.1016/j.cell.2020.08.013). external pageOnlinecall_made

L. Dong, P. S. Ravaynia, Q. A. Huang, A. Hierlemann, M. M. Modena, "Parallelized wireless sensing system for continuous monitoring of microtissue spheroids", ACS Sensors 2020, 5 (7), 2036–2043 (DOI: 10.1021/acssensors.0c00481). external pageOnlinecall_made

I. Mannaerts, N. Eysackers, E. A. van Os, S. Verhulst, T. Roosens, A. Smout, A. Hierlemann, O. Frey, S. Batista Leite, L. A. van Grunsven, "The fibrotic response of primary liver spheroids recapitulates in vivo hepatic stellate cell activation", Biomaterials 2020, Vol. 261, Article 120335 (DOI: 10.1016/j.biomaterials.2020.120335). external pageOnlinecall_made

L. L. Sohn, P. Schwille, A. Hierlemann, S. Tay, J. Samitier, J. Fu, P. Loskill, "How can microfluidic and microfabrication approaches make experiments more physiologically relevant?", Cell Systems 2020, September Voices (DOI: 10.1016/j.cels.2020.07.003). external pageOnlinecall_made

M. Kollo, R. Racz, M.-E. Hanna, A. Obaid, M.R. Angle, W. Wray, Y. Kong, J. Müller, A. Hierlemann, N. A. Melosh, A.T. Schaefer, "CHIME: CMOS-hosted in vivo microelectrodes for massively scalable neuronal recordings", Front. Neurosci. 2020, 14:834 (DOI: 10.3389/fnins.2020.00834). external pageOnlinecall_made

R. Nudischer, K. Renggli, A. Hierlemann, A. B. Roth, C. Bertinetti-Lapatki, "Characterization of a long-term mouse primary liver 3D tissue model recapitulating innate-immune responses and drug-induced liver toxicity", PLoS ONE 2020, 15(7):e0235745 (DOI: 10.1371/journal.pone.0235745). external pageOnlinecall_made

A. Obaid, M. E. Hanna, Y.-W. Wu, M. Kollo, R. Racz, M. R. Angle, J. Müller, N. Brackbill, W. Wray, F. Franke, E. J. Chichilnisky, A. Hierlemann, J. B. Ding, A. T. Schaefer, N. A. Melosh, "Massively parallel microwire arrays integrated with CMOS chips for neural recording", Science Advances 2020, 6 (12), Article eaay2789 (DOI: 10.1126/sciadv.aay2789). external pageOnlinecall_made

P. Misun, B. Yesildag, F. Forschler, A. Neelakandhan, N. Rousset, A. Biernath, A. Hierlemann, O. Frey, "In-vitro platform for studying human insulin release dynamics of single pancreatic islet microtissues at high resolution", Advanced Biosystems 2020, Article 1900291 (DOI: 10.1002/adbi.201900291). external pageOnlinecall_made

R. Nudischer, K. Renggli, C. Bertinetti-Lapatki, J.-C. Hoflack, N. Flint, S. Sewing, L. Pedersen, S. Schadt, L. G Higgins, A. Vardy, B. Lenz, L. Gand, F. Boess, B. M. Elcombe, A. Hierlemann, A. B Roth, "Combining in vivo and organotypic in vitro approaches to assess the human relevance of Basimglurant (RG7090), a potential CAR activator", Toxicological Sciences 2020, Article kfaa076, (DOI: 10.1093/toxsci/kfaa076). Online

B. Gaub, K. Kasuba, E. Mace, T. Strittmatter, P. Laskowski, S. Geissler, A.Hierlemann, M. Fussenegger, B. Roska, D. Müller, "Neurons differentiate magnitude and location of mechanical stimuli", Proceedings of the National Academy of Sciences 2020, 117 (2), pp. 848-856 (DOI: 10.1073/pnas.1909933117). external pageOnlinecall_made

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2019

J. Boos, P. Misun, A. Michlmayr, A. Hierlemann, O. Frey, "Microfluidic multitissue platform for advanced embryotoxicity testing in vitro", Advanced Science 2019, Article 1900294 (DOI: 10.1002/advs.201900294). external pageOnlinecall_made

V. Viswam, M. Engelene Obien, F. Franke, U. Frey, A. Hierlemann, "Optimal electrode size for multi-scale extracellular-potential recording from neuronal assemblies", Frontiers in Neuroscience 2019, 13, Article 385 (DOI: 10.3389/fnins.2019.00385). external pageOnlinecall_made

V. Emmenegger, M. Engelene Obien, F. Franke, A. Hierlemann, "Technologies to study action potential propagation with a focus on HD-MEAs", Frontiers in Cellular Neuroscience 2019, 13, Article 159 (DOI: 10.3389/fncel.2019.00159). external pageOnlinecall_made

A. Dudina, U. Frey, A. Hierlemann, "Carbon-nanotube-based monolithic CMOS platform for electrochemical detection of the neurotransmitter glutamate", Sensors 2019, 19 (14), 3080 (DOI: 10.3390/s19143080). external pageOnlinecall_made

T. Bullmann, M. Radivojevic, S. Huber, K. Deligkaris, A. Hierlemann, U. Frey, "Large-scale mapping of axonal arbors using high-density microelectrode arrays", Frontiers in Cellular Neuroscience 2019, 13, Article 404 (DOI: 10.3389/fncel.2019.00404) external pageOnlinecall_made.

T. Russell, J. Zhang, M. Okoniewski, F. Franke, S. Bichet, A. Hierlemann, "Medullary respiratory circuit is reorganized by a seasonally-induced program in preparation for hibernation", Frontiers in Neuroscience 2019, 13, Article 376 (DOI: 10.3389/fnins.2019.00376). external pageOnlinecall_made

K. Renggli, N. Rousset, C. Lohasz, O.T.P. Nguyen, A. Hierlemann, "Integrated microphysiological systems: Transferable organ models and recirculating flow", Advanced Biosystems 2019, Article 1900018 (DOI: 10.1002/adbi.201900018). external pageOnlinecall_made

C. Lohasz, O. Frey, F. Bonanini, K. Renggli, A. Hierlemann, "Tubing-free microfluidic microtissue culture system featuring gradual, in vivo-like substance exposure profiles", Frontiers in Bioengineering and Biotechnology 2019, 7, Article 72 (DOI: 10.3389/fbioe.2019.00072). Online

S. Ronchi, M. Fiscella, C. Marchetti, V. Viswam, J. Müller, U. Frey, A. Hierlemann, "Single-cell electrical stimulation using CMOS-based high-density microelectrode arrays", Frontiers in Neuroscience 2019, 13, Article 208 (DOI: 10.3389/fnins.2019.00208). external pageOnlinecall_made

T. Mita, D. Bakkum, U. Frey, A. Hierlemann, R. Kanzaki, H. Takahashi, "Classification of inhibitory and excitatory neurons of dissociated cultures based on action-potential waveforms on high-density CMOS microelectrode arrays", IEEJ Transactions on Electronics, Information and Systems 2019, 139 (5), pp. 615-624 (DOI: 10.1541/ieejeiss.139.615). external pageOnlinecall_made

M. Engelene Obien, A. Hierlemann, U. Frey, "Accurate signal-source localization in brain slices by means of high-density microelectrode arrays", Scientific Reports 2019, Vol. 9, Article 788 (DOI: 10.1038/s41598-018-36895-y). external pageOnlinecall_made

A. Dudina, F. Seichepine, Y. Chen, A. Stettler, A. Hierlemann, U. Frey, "Monolithic CMOS sensor platform featuring an array of 9’216 carbon-nanotube-sensor elements and low-noise, wide-bandwidth and wide-dynamic-range readout circuitry", Sensors & Actuators B (Chemical) 2019, Vol. 279, pp. 255-266 (DOI: 10.1016/j.snb.2018.10.004). external pageOnlinecall_made

A. Shadmani, V. Viswam, Y. Chen, R. Bounik, J. Dragas, M. Radivojevic, S. Geissler, S. Sitnikov, J. Müller, A. Hierlemann, "Stimulation and artifact-suppression techniques for in-vitro high-density microelectrode array systems", IEEE Transactions on Biomedical Engineering, 2019, 66 (9), pp. 2481-2490 (DOI: 10.1109/TBME.2018.2890530). external pageOnlinecall_made

D. Bakkum, M. Engelene J. Obien, M. Radivojevic, D. Jäckel, U. Frey, H. Takahashi, A. Hierlemann, "The axon initial segment is the dominant contributor to the neuron's extracellular electrical potential landscape", Advanced Biosystems 2019, 3, 1800308 (DOI: 10.1002/adbi.201800308). external pageOnlinecall_made

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2018

K. Chawla, M. Modena, P. Ravaynia, F. Lombardo, M. Leonhardt, G. Panic, S. Bürgel, J. Keiser, and A. Hierlemann, "Impedance-based microfluidic assay for automated antischistosomal drug screening", ACS Sensors 2018, 3 (12), pp. 2613–2620 (DOI: 10.1021/acssensors.8b01027). external pageOnlinecall_made

V. Viswam, R. Bounik, A. Shadmani, J. Dragas, C. Urwyler, J. Boos, M. Obien, J. Müller, Y. Chen, A. Hierlemann, "Impedance spectroscopy and electrophysiological imaging of cells with a high-density CMOS microelectrode array system", IEEE Trans. Biomed. Circuits Syst. 2018, 12 (6), pp. 1356-1368 (DOI: 10.1109/TBCAS.2018.2881044). external pageOnlinecall_made

M. Lewandowska, E. Bogatikov, A. Hierlemann, A. Rostedt Punga, "Long-term high-density extracellular recordings enable studies of muscle cell physiology", Frontiers in Physiology 2018, Vol. 9, article 1424 (DOI: 10.3389/fphys.2018.01424). external pageOnlinecall_made

C. Lohasz, N. Rousset, K. Renggli, A. Hierlemann, O. Frey, "Scalable microfluidic platform for flexible configuration of and experiments with microtissue multiorgan models", SLAS Technology 2018, in press, pp. 1-17 (DOI: 10.1177/2472630318802582). external pageOnlinecall_made

R. Diggelmann, M. Fiscella, A. Hierlemann, F. Franke, "Automatic Spike Sorting Algorithm for High-Density Microelectrode Arrays", Journal of Neurophysiology 2018, 120 (6), pp. 3155–3171 (DOI: 10.1152/jn.00803.2017). external pageOnlinecall_made

A. Drinnenberg, F. Franke, R. K. Morikawa, J. Jüttner, D. Hillier, P. Hantz, A. Hierlemann, R. A. da Silveira, B. Roska, "How diverse retinal functions arise from feedback at the first visual synapse", Neuron 2018, Vol. 99 (1), pp. 117-134.e11 (DOI: 10.1016/j.neuron.2018.06.001). external pageOnlinecall_made / external pagePreviewcall_made

B. van Lier, A. Hierlemann, F. Knoflach, "Parvalbumin expression and gamma oscillation occurrence increase over time in a neurodevelopmental model of NMDA receptor dysfunction", PeerJ 2018-09-19 (DOI: 10.7717/peerj.5543). external pageOnlinecall_made

K. Chawla, S Bürgel, G. Schmidt, H-M. Kaltenbach, F. Rudolf, O. Frey, Andreas Hierlemann, "Integrating impedance-based growth-rate monitoring into a microfluidic cell culture platform for live-cell microscopy", Microsystems & Nanoengineering 2018, 4:8 (DOI 10.1038/s41378-018-0006-5). external pageOnlinecall_made

E. Aeby, P. Misun, A. Hierlemann, O. Frey, "Microfluidic hydrogel hanging-drop network for long-term culturing of 3D microtissues and simultaneous high-resolution imaging", Advanced Biosystems 2018, 2, 1800054 (DOI: 10.1002/adbi.201800054). external pageOnlinecall_made

Yonghong Tao, Andreas Hierlemann, "A 15-channel 30-V neural stimulator for spinal cord repair", IEEE Transactions on Very Large Scale Integration (VLSI) Systems 2018, Vol. 26 (10), pp. 2185-2189 (DOI: 10.1109/TVLSI.2018.2832051). external pageOnlinecall_made

M. Modena, K. Chawla, P. Misun, A. Hierlemann, "Smart cell-culture systems: Integration of sensors and actuators into microphysiological systems", ACS Chem. Biol. 2018, 13 (7), pp 1767–1784 (DOI: 10.1021/acschembio.7b01029). external pageOnlinecall_made

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2017

M. Radivojevic, F. Franke, M. Altermatt, J. Müller, A. Hierlemann, D. Bakkum, "Tracking individual action potentials throughout mammalian axonal arbors", eLife 2017, 6:e30198 (DOI: 10.7554/eLife.30198). external pageOnlinecall_made

J. Dragas, V. Viswam, A. Shadmani, Y. Chen, R. Bounik, A. Stettler, M. Radivojevic, S. Geissler, M. Engelene J. Obien, J. Müller, A. Hierlemann, "In-vitro multi-functional microelectrode array featuring 59760 electrodes, 2048 electrophysiology channels, stimulation, impedance measurement and neurotransmitter detection channels", IEEE Journal of Solid-State Circuits, 2017, Volume 52 (6), pp. 1576-1590 (DOI:10.1109/JSSC.2017.2686580). external pageOnlinecall_made

D. Hillier, M. Fiscella, A. Drinnenberg, S. Trenholm, S.B. Rompani, Z. Raics, G. Katona, J. Juettner, A. Hierlemann, B. Rozsa, B. Roska, "Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex", Nature Neuroscience 2017, Vol. 20, pp. 960–968 (DOI:10.1038/nn.4566). external pageOnlinecall_made

D. Jäckel, D. J. Bakkum, T. L. Russell, J. Müller, M. Radivojevic, U. Frey, F. Franke & A. Hierlemann, "Combination of high-density microelectrode array and patch clamp recordings to enable studies of multisynaptic integration", Scientific Reports 2017, Vol. 7, Art. No. 978 (DOI:10.1038/s41598-017-00981-4). external pageOnlinecall_made

F. Seichepine, J. Rothe, A. Dudina, A. Hierlemann, and U. Frey, "Dielectrophoresis-assisted integration of 1024 carbon nanotube sensors into a CMOS microsystem", Advanced Materials, 2017, Vol. 29, No. 17, p. 1606852 (DOI: 10.1002/adma.201606852). external pageOnlinecall_made

J. Rothe, O. Frey, R. Madangopal, J. Rickus, Andreas Hierlemann, "Robust functionalization of large microelectrode arrays by using pulsed potentiostatic deposition", Sensors 2017, 17(1), 22 (DOI:10.3390/s17010022). external pageOnlinecall_made

Y. Yada, T. Mita, A. Sanada, R. Yano, R. Kanzaki, D. Bakkum, A. Hierlemann, H. Takahashi, "Development of neural population activity towards self-organized criticality", Neuroscience 2017, 343, pp. 555-565 (DOI: 10.1016/j.neuroscience.2016.11.031). external pageOnlinecall_made

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2016

W. Gong, J. Senčar, D.J. Bakkum, D. Jäckel, M. Engelene J. Obien, M. Radivojevic, and A. Hierlemann, "Multiple single-unit long-term tracking on organotypic hippocampal slices using high-density microelectrode arrays", Front. Neurosci. 2016, 10:537 (DOI: 10.3389/fnins.2016.00537). external pageOnlinecall_made

S. Bürgel, L. Diener, O. Frey, J.Y. Kim, A. Hierlemann, "Automated, multiplexed electrical impedance spectroscopy platform for continuous monitoring of microtissue spheroids", Analytical Chemistry 2016, 88 (22), pp. 10876–10883 (DOI: 10.1021/acs.analchem.6b01410). external pageOnlinecall_made

M. Radivojevic, D. Jäckel, M. Altermatt, J. Müller, V. Viswam, A. Hierlemann, D. Bakkum, "Electrical identification and selective microstimulation of neuronal compartments based on features of extracellular action potentials", Scientific Reports 2016, 6, 31332 (DOI:10.1038/srep31332). external pageOnlinecall_made

K. Deligkaris, T. Bullmann, and U. Frey, “Extracellularly recorded somatic and neuritic signal shapes and classification algorithms for high-density microelectrode array electrophysiology”, Front. Neurosci., 10:421, 2016, (DOI: 10.3389/fnins.2016.00421). external pageOnlinecall_made

P. Misun, J. Rothe, Y. Schmid, A. Hierlemann, O. Frey, "Multi-analyte biosensor interface for real-time monitoring of 3D microtissue spheroids in hanging-drop networks", Microsystems & Nanoengineering, 2016, 2, article 16022 (DOI: 10.1038/micronano.2016.22). external pageOnlinecall_made

Y. Schmid, S. Bürgel, P. Misun, A. Hierlemann, O. Frey, "Electrical impedance spectroscopy for microtissue spheroid analysis in hanging-drop networks", ACS Sensors 2016, 1 (8), pp 1028–1035 (DOI: 10.1021/acssensors.6b00272). external pageOnlinecall_made

N. Haandbaek, S. C. Bürgel, F. Rudolf, F. Heer, and A. Hierlemann, "Characterization of single yeast cell phenotypes using microfluidic impedance cytometry and optical imaging", ACS Sensors 2016, 1 (8), pp 1020–1027 (DOI: 10.1021/acssensors.6b00286). external pageOnlinecall_made

M. K. Lewandowska, M. Radivojević, D. Jäckel, J. Müller, and A. Hierlemann, "Cortical axons, isolated in channels, display activity-dependent signal modulation as a result of targeted stimulation", Front. Neurosci. 2016, 10:83 (DOI: 10.3389/fnins.2016.00083). external pageOnlinecall_made

K. Yonehara, M. Fiscella, A. Drinnenberg, F. Esposti, S. Trenholm, J. Krol, F. Franke, B. Gross-Scherf, A. Kusnyerik, J. Müller, A. Szabo, J. Jüttner, F. Cordoba, A. P. Reddy, J. Németh, Z. Nagy, F. Munier, A. Hierlemann, B. Roska, "Congenital nystagmus gene FRMD7 is necessary for establishing a neuronal circuit asymmetry for direction selectivity", Neuron, 2016, 89(1), pp. 177-193 (DOI: 10.1016/j.neuron.2015.11.032). external pageOnlinecall_made / external pageVideo abstractcall_made
Received external pageSwiss OphthAwardcall_made 2016 of the external pageSwiss Society of Ophthalmologycall_made in Category Best Experimental Work.

F. Franke, M. Fiscella, M. Sevelev, B. Roska, A. Hierlemann, R. Azeredo da Silveira, "Structures of neural correlation and how they favor coding", Neuron, 2016, 89(2), pp. 409-422 (DOI: 10.1016/j.neuron.2015.12.037). external pageOnlinecall_made

A. Birchler, M. Berger, V. Jaeggin, T. Lopes, M.  Etzrodt, P. Misun, M. Pena-Francesch, T. Schroeder, A. Hierlemann, O. Frey, "Seamless combination of FACS and hanging-drop networks for individual handling and culturing of stem cells and microtissue spheroids", Analytical Chemistry, 2016, 88 (2), pp. 1222–1229 (DOI: 10.1021/acs.analchem.5b03513). external pageOnlinecall_made

R. F. Steinhoff, D. J. Karst, F. Steinebach, M. R. Kopp, G. W. Schmidt, A. Stettler, J. Krismer, M. Soos, M. Pabst, A. Hierlemann, M. Morbidelli, R. Zenobi, "Microarray-based MALDI-TOF mass spectrometry enables monitoring of monoclonal antibody production in batch and perfusion cell cultures", Methods, 2016, 104, pp. 33-40 (DOI: 10.1016/j.ymeth.2015.12.011). external pageOnlinecall_made

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2015

B. Sorce, C. Escobedo, Y. Toyoda, M. Stewart, C. Cattin, R. Newton, I. Banerjee, A. Stettler, B. Roska, S. Eaton, A. Hyman, A. Hierlemann, D. J. Müller, "Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement", Nature Communications, 2015, 6:8872 (DOI: 10.1038/ncomms9872). external pageOnlinecall_made

Z. Zhu, O. Frey, N. Haandbaek, F. Franke, F. Rudolf, A. Hierlemann, "Time-lapse electrical impedance spectroscopy for monitoring the cell cycle of single immobilized S. pombe cells", Scientific Reports, 2015, 5, 17180 (DOI: 10.1038/srep17180). external pageOnlinecall_made

I. L. Jones, T. L. Russell, K. Farrow, M. Fiscella, F. Franke, J. Müller, D. Jäckel and A. Hierlemann, "A method for electrophysiological characterization of hamster retinal ganglion cells using a high-density CMOS microelectrode array", Front. Neurosci., 2015, 9:360 (DOI: 10.3389/fnins.2015.00360). external pageOnlinecall_made

S. Rismani Yazdi, A. Shadmani, S. Bürgel, P. Misun, A. Hierlemann, O. Frey, "Adding the 'heart' to hanging drop networks for microphysiological multi-tissue experiments", Lab Chip, 2015, 15, pp. 4138- 4147 (DOI: 10.1039/C5LC01000D). external pageOnlinecall_made

P. Livi, M. Kwiat, A. Shadmani, J. Rothe, G. Navarra, A. Pevzner, A. Stettler, Y. Chen, F. Patolsky, and A. Hierlemann, "Monolithic integration of a silicon nanowire FET array on a CMOS chip for bio-chemical sensor applications", Anal. Chem., 2015, 87 (19), pp 9982–9990 (DOI: 10.1021/acs.analchem.5b02604). external pageOnlinecall_made

K. Liu, Z. Zhu, X. Wang, D. Gonçalves, B. Zhang, A. Hierlemann, P. Hunziker "Microfluidics-based single-step preparation of injection-ready polymeric nanosystems for medical imaging and drug delivery", Nanoscale, 2015, 7, 16983-16993 (DOI: 10.1039/C5NR03543K). external pageOnlinecall_made

M. Fiscella, F. Franke, K. Farrow, J. Müller, B. Roska, R. Azeredo da Silveira, A. Hierlemann, "Visual coding with a population of direction-selective neurons", Journal of Neurophysiology, 2015 (DOI: 10.1152/jn.00919.2014). external pageOnlinecall_made

J. Krol, I. Krol, C. P. Patino Alvarez, M. Fiscella, A. Hierlemann, B. Roska, W. Filipowicz, "A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture", Nature Communications, 2015, 6:7305 (DOI:10.1038/ncomms8305). external pageOnlinecall_made

C. R. Escobedo, S. C. Bürgel, S. Kemmerling, N. Sauter, T. Braun, A. Hierlemann, "On-chip lysis of mammalian cells through a handheld corona device", Lab Chip, 2015, 15, pp. 2990-2997 (DOI: 10.1039/C5LC00552C). external pageOnlinecall_made

J. Müller, M. Ballini, P. Livi, Y. Chen, M. Radivojevic, A. Shadmani, V. Viswam, I. L. Jones, M. Fiscella, R. Diggelmann, A. Stettler, U. Frey, D. J. Bakkum, A. Hierlemann, "High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels", Lab Chip, 2015, 15, pp. 2767-2780 (DOI: 10.1039/C5LC00133A). external pageOnlinecall_made

O. Frey, F. Rudolf, G. W. Schmidt, A. Hierlemann, "Versatile, simple-to-use microfluidic cell-culturing chip for long-term, high-resolution, time-lapse imaging", Anal. Chem., 2015, 87 (8), pp. 4144–4151 (DOI: 10.1021/ac504611t). external pageOnlinecall_made

Y. Tao, A. Hierlemann, Y. Lian, "A frequency-domain analysis of latch comparator offset due to load capacitor mismatch", IEEE Transactions on Circuits and Systems II, 2015, 62 (6), pp. 527-532 (DOI: 10.1109/TCSII.2015.2406832). external pageOnlinecall_made

J. Dragas, D. Jaeckel, A. Hierlemann, F. Franke, "Complexity Optimisation and High-Throughput Low-Latency Hardware Implementation of a Multi-Electrode Spike-Sorting Algorithm", IEEE Trans. On Neural Systems and Rehabilitation Engineering, 2015, 23(2), pp. 149-158 (DOI: 10.1109/TNSRE.2014.2370510). external pageOnlinecall_made

M. K. Lewandowska, D. J. Bakkum, S. B. Rompani, A. Hierlemann, "Recording Large Extracellular Spikes in Microchannels along Many Axonal Sites from Individual Neurons", PLoS ONE, 2015, 10(3): e0118514 (DOI: 10.1371/journal.pone.0118514). external pageOnlinecall_made

F. Franke, R. Q. Quiroga, A. Hierlemann, K. Obermayer "Bayes Optimal Template Matching for Spike Sorting - Combining Fisher Discriminant Analysis with Optimal Filtering", Journal of Computational Neuroscience, 2015, 38 (3), pp. 439-459 (DOI: 10.1007/s10827-015-0547-7). external pageOnlinecall_made

J-Y. Kim, D. Fluri, R. Marchan, K. Boonen, S. Mohanty, P. Singh, S. Hammad, B. Landuyt, J. G Hengstler, J. M. Kelm, A. Hierlemann, O. Frey, "3D Spherical Microtissues and Microfluidic Technology for Multi-tissue Experiments and Analysis", Journal of Biotechnology, 2015, 205, pp. 24–35 (DOI: 10.1016/j.jbiotec.2015.01.003). external pageOnlinecall_made

S. C Bürgel, C. Escobedo, N. Haandbæk, A. Hierlemann, "On-chip Electroporation and Impedance Spectroscopy of Single Cells", Sensors and Actuators B: Chemical, 2015, 210, pp. 82-90 (DOI: 10.1016/j.snb.2014.12.016). external pageOnlinecall_made

S. Okawa, T. Mita, D. Bakkum, U. Frey, A. Hierlemann, R. Kanzaki, H. Takahashi, "Chronic Co‐Variation of Neural Network Configuration and Activity in Mature Dissociated Cultures", Electronics and Communications in Japan 98 (5), pp. 34-42 (DOI: 10.1002/ecj.11736). external pageOnlinecall_made

J. Kim, D.A. Fluri, J.M. Kelm, A. Hierlemann, O. Frey, "96-Well Format-Based Microfluidic Platform for Parallel Interconnection of Multiple Multicellular Spheroids", Journal of Laboratory Automation, 2015, 20(3), pp. 274–282 (DOI: 10.1177/2211068214564056). external pageOnlinecall_made

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2014

O. Frey, P. Misun, D. Fluri, J. Hengstler, A. Hierlemann, "Reconfigurable Microfluidic Hanging-drop Network for Multi-tissue interaction and Analysis", Nature Communications, 2014, 5:4250 (DOI: 10.1038/ncomms5250). external pageOnlinecall_made
Received Highly Commended Award in the 2014 external page3Rs Prizecall_made competition of the British external pageNC3Rscall_made.

M. Ballini, J. Mueller, P. Livi, Y. Chen, U. Frey, A. Stettler, A. Shadmani, V. Viswam, I. Jones, D. Jäckel,  M. Radivojevic, M. Lewandowska, W. Gong, M. Fiscella, D. Bakkum, F. Heer, and A. Hierlemann, "A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro", IEEE Journal of Solid-State Circuits, 2014, 49, pp. 2705–2719 (DOI: 10.1109/JSSC.2014.2359219). external pageOnlinecall_made

M.J. Obien, K. Deligkaris, T. Bullmann, D.J. Bakkum, U. Frey, "Revealing Neuronal Function through Microelectrode Array Recordings", Frontiers in Neuroscience 8:423, 2014 (DOI: 10.3389/fnins.2014.00423). external pageOnlinecall_made

P. Livi, A. Shadmani, M. Wipf, R. Stoop, J. Rothe, Y. Chen, M. Calame, C. Schönenberger, A. Hierlemann, "Sensor System including Silicon Nanowire Ion Sensitive FET Arrays and CMOS readout", Sensors and Actuators B: Chemical, 2014, 204 (1), pp 568–577 (DOI: 10.1016/j.snb.2014.08.002). external pageOnlinecall_made

D. Ausländer, S. Ausländer, G. Charpin-El Hamri, F. Sedlmayer, M. Müller, O. Frey, A. Hierlemann, J. Stelling, M. Fussenegger, "A Synthetic Multifunctional Mammalian pH Sensor and CO₂ Transgene-Control Device", Molecular Cell, 2014, 55, 1-12 (DOI: 10.1016/j.molcel.2014.06.007). external pageOnlinecall_made

Z. Zhu, O. Frey, F. Franke, N. Haandbæk, A. Hierlemann, "Real-time Monitoring of Immobilized Single Yeast Cells through Multifrequency Electrical Impedance Spectroscopy", Analytical and Bioanalytical Chemistry, 2014, 406 (27): 7015-7025 (DOI: 10.1007/s00216-014-7955-9). external pageOnlinecall_made

N. Haandbaek, S. C. Bürgel, F. Heer and A. Hierlemann, "Resonance-enhanced Microfluidic Impedance Cytometer for Detection of Single Bacteria", Lab on a Chip, 2014, 14, 3313-3324 (DOI: 10.1039/C4LC00576G). external pageOnlinecall_made

J. Rothe, O. Frey, A. Stettler, Y. Chen, A. Hierlemann, "Fully Integrated CMOS Microsystem for Electrochemical Measurements on 32× 32 Working Electrodes at 90 Frames Per Second", Anal. Chem., 2014, 86 (13), pp. 6425–6432 (DOI: 10.1021/ac500862v). external pageOnlinecall_made

N. Haandbaek, S. C. Bürgel, F. Heer and A. Hierlemann, "Characterization of Subcellular Morphology of Single Yeast Cells Using High Frequency Microfluidic Impedance Cytometer", Lab on a Chip, 2014, 14(2), pp. 369-377, (DOI: 10.1039/C3LC50866H). external pageOnlinecall_made

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2013

D.J Bakkum, M. Radivojevic, U. Frey, F. Franke, A. Hierlemann and H. Takahashi "Parameters for Burst Detection", Front. Comput. Neurosci. 2013, 7:193 (DOI:10.3389/fncom.2013.00193). external pageOnlinecall_made

O. Frey, J. Rothe, F. Heer, P. D. van der Wal, N. F. de Rooij and A. Hierlemann, "Multi-site Monitoring of Choline Using Biosensor Microprobe Arrays in Combination with CMOS Circuitry", Biomedical Engineering/Biomedizinische Technik, 2013 (DOI: 10.1515/bmt-2012-0098). external pageOnlinecall_made

N. Haandbaek, S. C. Bürgel, F. Heer and A. Hierlemann,"Development of a Microfluidic GHz Impedance Cytometer", tm – Technisches Messen, 2013, 80(12), pp. 411–420 (DOI: 10.1524/teme.2013.0053). external pageOnlinecall_made

Douglas J. Bakkum, Urs Frey, Milos Radivojevic, Thomas L. Russell, Jan Müller, Michele Fiscella, Hirokazu Takahashi, Andreas Hierlemann, "Tracking Axonal Action Potential Propagation on a High-density Microelectrode Array across Hundreds of Sites", Nature Communications, 2013, 4:2181 (DOI: 10.1038/ncomms3181). external pageOnlinecall_made

Sara Rigante, Paolo Livi, Alexandru Rusu, Yihui Chen, Antonios Bazigos, Andreas Hierlemann, Adrian M. Ionescu, "FinFET Integrated Low-Power Circuits for Enhanced Sensing Applications", Sensors and Actuators B: Chemical, 2013, 186, pp. 789–795 (DOI: 10.1016/j.snb.2013.06.031). external pageOnlinecall_made

Jan Müller, Douglas Bakkum and Andreas Hierlemann, "Sub-millisecond closed-loop feedback stimulation between arbitrary sets of individual neurons", Frontiers in Neural Circuits, 2013, 6:121 (DOI: 10.3389/fncir.2012.00121). external pageOnlinecall_made

Simon Kemmerling, Stefan A. Arnold, Benjamin A. Bircher, Nora Sauter, Carlos Escobedo, Gregor Dernick, Andreas Hierlemann, Henning Stahlberg, Thomas Braun, "Single-cell lysis for visual analysis by electron microscopy", Journal of Structural Biology, 2013, 183 (3), pp. 467–473 (DOI: 10.1016/j.jsb.2013.06.012). external pageOnlinecall_made

Paolo Livi, Kristine Bedner, Alexey Tarasov, Mathias Wipf, Yihui Chen, Christian Schönenberger, Andreas Hierlemann, "A Verilog-A model for silicon nanowire biosensors: from theory to verification", Sensors and Actuators B: Chemical, 2013, Vol. 179. pp. 293-300 (DOI: 10.1016/j.snb.2012.09.026). external pageOnlinecall_made

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2012

Felix Franke, David Jäckel, Jelena Dragas, Jan Müller, Milos Radivojevic, Douglas Bakkum and Andreas Hierlemann, "High-density microelectrode array recordings and real-time spike sorting for closed-loop experiments: an emerging technology to study neural plasticity", Frontiers in Neural Circuits, 2012, 6:105 (DOI: 10.3389/fncir.2012.00105). external pageOnlinecall_made

Michele Fiscella, Karl Farrow, Ian L. Jones, David Jäckel, Jan Müller, Urs Frey, Douglas J. Bakkum, Péter Hantz, Botond Roska, Andreas Hierlemann, "Recording from defined populations of retinal ganglion cells using a high-density CMOS-integrated microelectrode array with real-time switchable electrode selection", Journal of Neuroscience Methods, 2012, Volume 211, Issue 1, pp. 103–113 (DOI: 10.1016/j.jneumeth.2012.08.017). external pageOnlinecall_made

Zhen Zhu, Olivier Frey, Diana Silvia Ottoz, Fabian Rudolf, Andreas Hierlemann, "Microfluidic single-cell cultivation chip with controllable immobilization and selective release of yeast cells", Lab on a Chip, 2012, 12, 906-915 (DOI: 10.1039/c2lc20911j). external pageOnlinecall_made

Simon Kemmerling, Jörg Ziegler, Gabriel Schweighauser, Stefan A. Arnold, Dominic Giss, Shirley A. Müller, Philippe Ringler, Kenneth N. Goldie, Nils Goedecke, Andreas Hierlemann, Henning Stahlberg, Andreas Engel, Thomas Braun, "Connecting μ-fluidics to electron microscopy", Journal of Structural Biology, 2012, Vol. 177, pp. 128–134 (DOI: 10.1016/j.jsb.2011.11.001). external pageOnlinecall_made

David Jäckel, Urs Frey, Michele Fiscella, Felix Franke and Andreas Hierlemann, "Applicability of Independent Component Analysis on High-Density Microelectrode Array Recordings", Journal of Neurophysiology, 2012, 108 (1), pp. 334-348 (DOI: 10.1152/jn.01106.2011). external pageOnlinecall_made

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2011

J. Rothe, M. K. Lewandowska, F. Heer, O. Frey and A. Hierlemann, "Multi-target electrochemical biosensing enabled by integrated CMOS electronics", Journal of Micromechanics and Microengineering, 2011, 21(5), p. 054010 (DOI: 10.1088/0960-1317/21/5/054010. external pageOnlinecall_made

A. Hierlemann, U. Frey, S. Hafizovic, F. Heer, "Growing Cells atop Microelectronic Chips: Interfacing Electrogenic Cells in Vitro with CMOS-based Microelectrode Arrays", Proceedings of the IEEE, 2011, Vol. 99, No. 2, pp. 252-284 (DOI: 10.1109/JPROC.2010.2066532). external pageOnlinecall_made

Ian L. Jones, Paolo Livi, Marta K. Lewandowska, Michele Fiscella, Branka Roscic and Andreas Hierlemann, "The potential of microelectrode arrays and microelectronics for biomedical research and diagnostics", Analytical and Bioanalytical Chemistry, 2011, Volume 399 (7), 2313-2329 (DOI: 10.1007/s00216-010-3968-1). external pageOnlinecall_made

S.B. Truax, K.S. Demirci, L.A. Beardslee, Y. Luzinova, A. Hierlemann, B. Mizaikoff, O. Brand, "Mass-Sensitive Detection of Gas-Phase Volatile Organics Using Disk Microresonators", Analytical Chemistry, 2011, 83 (9), pp. 3305-3311 (DOI: 10.1021/ac1029902). external pageOnlinecall_made

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2010

U. Frey, J. Sedivy, F. Heer, R. Pedron, M. Ballini, J. Mueller, D. Bakkum, S. Hafizovic, F. D. Faraci, F. Greve, K.-U. Kirstein, and A. Hierlemann, "Switch-matrix-based high-density microelectrode array in CMOS technology", IEEE Journal of Solid-State Circuits, Vol. 45, no. 2, pp. 467–482, 2010 (DOI: 10.1109/JSSC.2009.2035196). external pageOnlinecall_made

Ricardo Gutierrez-Osuna and Andreas Hierlemann, "Adaptive Microsensor Systems", Annu. Rev. Anal. Chem., Vol. 3, pp 255–76, 2010 (DOI: 10.1146/annurev.anchem.111808.073620). external pageOnlinecall_made

A. Perera, A. Pardo, D. Barrettino, A. Hierlemann, S. Marco, "Evaluation of fish spoilage by means of a single metal oxide sensor under temperature modulation", Sensors and Actuators B, Chemical, 2010, 146, 477-482 (DOI: 10.1016/j.snb.2009.11.037). external pageOnlinecall_made

Paolo Livi, Flavio Heer, Urs Frey, Douglas J. Bakkum, Andreas Hierlemann, "Compact Voltage and Current Stimulation Buffer for High-Density Microelectrode Arrays", IEEE Transactions on Biomedical Circuits and Systems, Vol. 4, No. 6, 2010, pp. 372-378 (DOI: 10.1109/TBCAS.2010.2080676). external pageOnlinecall_made

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2009

Petra Kurzawski, Volker Schurig and Andreas Hierlemann, "Chiral Sensing Using a Complementary Metal−Oxide Semiconductor-Integrated Three-Transducer Microsensor System", Analytical Chemistry, 2009, 81 (22), pp. 9353–9364 (DOI: 10.1021/ac9017007). external pageOnlinecall_made

U. Frey, U. Egert, F. Heer, S. Hafizovic, and A. Hierlemann, "Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices", Biosensors and Bioelectronics, vol. 24, no. 7, pp. 2191-2198, 2009 (DOI: 10.1016/j.bios.2008.11.028). external pageOnlinecall_made

Petra Kurzawski, Anja Bogdanski, Volker Schurig, Reinhard Wimmer and Andreas Hierlemann, "Direct Determination of the Enantiomeric Purity or Enantiomeric Composition of Methylpropionates Using a Single Capacitive Microsensor", Analytical Chemistry, vol. 81, no. 5, pp 1969–1975, 2009 (DOI: 10.1021/ac802455c). external pageOnlinecall_made

Wilfried Weber, Stefan Luzi, Maria Karlsson, Carlota Diaz Sanchez-Bustamante, Urs Frey, Andreas Hierlemann, and Martin Fussenegger, "A synthetic mammalian electro-genetic transcription circuit", Nucleic Acids Research, vol. 37, no. 4, pp. e33, 2009 (DOI: 10.1093/nar/gkp014). external pageOnlinecall_made

A. Hierlemann, P. Kurzawski, V. Schurig, "The use of different transduction principles for qualitative and quantitative chiral gas analysis", ECS Transactions, 19 (6), 227-239, 2009 (DOI: 10.1149/1.3118556). external pageOnlinecall_made  

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2008

P. Kurzawski, A. Bogdanski, V. Schurig, R. Wimmer, A. Hierlemann, "Opposite signs of capacitive microsensor signals upon exposure to the enantiomers of methyl propionates", Angew. Chem., International Edition, 2008, 47, 913-916 (DOI: 10.1002/anie.200704346). external pageOnlinecall_made

A. Hierlemann, R. Gutierrez-Osuna, "Higher-order Chemical Sensing", Chemical Reviews, 2008, 108, 563-613 (DOI: 10.1021/cr068116m). external pageOnlinecall_made

Antonio Tricoli, Markus Graf, Felix Mayer, Stéphane Kühne, Andreas Hierlemann and Sotiris E. Pratsinis, "Micropatterning Layers by Flame Aerosol Deposition - Annealing", Advanced Materials, 2008, 20, 3005-3010 (DOI: 10.1002/adma.200701844). external pageOnlinecall_made

Stéphane Kühne, Markus Graf, Antonio Tricoli,  Felix Mayer, Sotiris E. Pratsinis, Andreas Hierlemann, "Wafer-level flame-spray-pyrolysis deposition of gas-sensitive layers on microsensors", Journal of Micromechanics and Microengineering, 2008, 18, Article 035040 (DOI: 10.1088/0960-1317/18/3/035040). external pageOnlinecall_made  

Chunguang Jin, Petra Kurzawski, Andreas Hierlemann, and Edward T. Zellers, "Evaluation of Multi-Transducer Arrays for the Determination of Organic Vapor Mixtures", Anal. Chem., 2008, 80, 227-236 (DOI: 10.1021/ac0715120). external pageOnlinecall_made

Cyril Vančura, Isabelle Dufour, Stephen M. Heinrich, Fabien Josse, and Andreas Hierlemann, "Analysis of Resonating Microcantilevers Operating in a Viscous Liquid Environment", Sensors and Actuators A, Physical, 2008, 141, 43-51 (DOI: 10.1016/j.sna.2007.07.010). external pageOnlinecall_made

M. Zimmermann, T. Volden, K.-U. Kirstein, S. Hafizovic, J. Lichtenberg, Oliver Brand, and A. Hierlemann, "A CMOS-Based Integrated-System Architecture for a Static Cantilever Array", Sensors & Actuators: B. Chemical, 2008, 131, 254-264 (DOI: 10.1016/j.snb.2007.11.016). external pageOnlinecall_made

C. D. Sanchez-Bustamante, U. Frey, J. M. Kelm, A. Hierlemann, and M. Fussenegger, "Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression", Tissue Engineering Part A, 2008, 14(12), 1969-1988 (DOI: 10.1089/ten.tea.2007.0302). external pageOnlinecall_made

Yue Li, Cyril Vancura, Kai-Uwe Kirstein, Jan Lichtenberg, Andreas Hierlemann, "Monolithic Resonant cantilever-based CMOS Microsystem for Biochemical Sensing" , IEEE Transactions on Circuits and Systems I: Regular Papers, 2008, Volume 55, Issue 9, 2551 - 2560 (DOI: 10.1109/TCSI.2008.922027). external pageOnlinecall_made  

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2007

U. Frey, M. Graf, S. Taschini, K.-U. Kirstein, A. Hierlemann, "A digital CMOS architecture for a micro-hotplate array", IEEE Journal of Solid-State Circuits, Vol. 42, No. 2, February 2007, p. 441-450 (DOI: 10.1109/JSSC.2006.889367). external pageOnlinecall_made

D. Barrettino, P. Malcovati, M. Graf, S. Hafizovic, A. Hierlemann, "CMOS-based monolithic controllers for smart sensors comprising micromembranes and microcantilevers", IEEE Transactions on Circuits and Systems – 1: Regular Papers, Vol. 54. No. 1, January 2007, p. 141-152 (DOI: 10.1109/TCSI.2006.887457). external pageOnlinecall_made

W. Franks, S. Tosatti, F. Heer, P. Seif, M. Textor, A. Hierlemann, "Patterned cell adhesion by self-assembled structures for use with a CMOS cell-based biosensor", Biosensors and Bioelectronics, 22 (2007), p. 1426-1433 (DOI: 10.1016/j.bios.2006.06.031). external pageOnlinecall_made

F. Heer, S. Hafizovic, T. Ugniwenko, U. Frey, W. Franks, E. Perriard, J.-C. Perriard, A. Blau, C. Ziegler, A. Hierlemann, "Single-chip microelectronic system to interface with living cells", Biosensors and Bioelectronics, 22 (2007), p. 2546-2553 (DOI: 10.1016/j.bios.2006.10.003). external pageOnlinecall_made

F. Greve, J. Lichtenberg, K.-U. Kirstein, U. Frey, J.-C. Perriard, A. Hierlemann, "A perforated CMOS microchip for immobilization and activity monitoring of electrogenic cells", Journal of Micromechanics and Microengineering, 17 (2007) p. 4562-471 (DOI: 10.1088/0960-1317/17/3/007). external pageOnlinecall_made  

C. Vancura, Y. Li, J. Lichtenberg, K.-U. Kirstein, A. Hierlemann, "Liquid-phase chemical and biochemical detection using fully integrated magnetically actuated complementary metal oxide semiconductor resonant cantilever sensor systems", Analytical Chemistry, Vol. 78, No. 4 (2007), p. 1646-1654 (DOI: 10.1021/ac061795g). external pageOnlinecall_made

S. Hafizovic, F. Heer, T. Ugniwenko, U. Frey, A. Blau, C. Ziegler, A. Hierlemann, "A CMOS-based microelectrode array for interaction with neuronal cultures", Journal of Neuroscience Methods, Vol. 164 (2007), p. 93-106 (DOI://
doi:10.1016/j.jneumeth.2007.04.006). external pageOnlinecall_made  

O. Frey, S. Bonneick, A. Hierlemann, J. Lichtenberg, "Autonomous microfluidic multi-channel chip for real-time PCR with integrated liquid handling", Biomedical Microdevices, 9 (2007) p. 711-718 (DOI: 10.1007/s10544-007-9080-4). external pageOnlinecall_made

F. Greve, L. Seemann, A. Hierlemann, J. Lichtenberg, "A hybrid microsystem for parallel perfusion experiments on living cells", Journal of Micromechnics and Microengineering, Vol. 17 (2007) 1721-1730 (DOI: 10.1088/0960-1317/17/8/040). external pageOnlinecall_made

Y. Li, C. Vancura, D. Barrettino, M. Graf, C. Hagleitner, A. Kummer, M. Zimmermann, K.-U. Kirstein, A. Hierlemann, "Monolithic CMOS multi-transducer gas sensor microsystem for organic and inorganic analytes", Sensors and Actuators B, Vol. 126 (2007) 431-440 (DOI: 10.1016/j.snb.2007.03.035). external pageOnlinecall_made  

F. Greve, S. Frerker, A.G. Bittermann, C. Burkhardt, A. Hierlemann, H. Hall, "Molecular design and characterization of the neuron-microelectrode array interface", Biomaterials, 28 (2007) p. 5246-5258 (DOI: 10.1016/j.biomaterials.2007.08.010). external pageOnlinecall_made

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2006

A. Kummer, A. Hierlemann, "Configurable electrodes for capacitive-type sensors and chemical sensors", IEEE Sensors Journal, Vol. 6, No. 1, February 2006, pp 3-10 (DOI: 10.1109/JSEN.2005.856547). external pageOnlinecall_made

A. Kummer, T. Burg, A. Hierlemann, "Transient signal analysis using complementary metal oxide semiconductor capacitive chemical microsensors", Analytical Chemistry, Vol. 78, No. 1, January 2006, pp 279-290 (DOI: 10.1021/ac051430g). external pageOnlinecall_made

T. Kraus, E. Verpoorte, V. Linder, W. Franks, A. Hierlemann, F. Heer, S. Hafizovic, T. Fujii, N. de Rooij, S. Koster, "Characterization of a microfluidic dispensing sytem for localised stimulation of cellular networks", Lab Chip, 6, 2006, pp 218-229 (DOI: 10.1039/b511768b). external pageOnlinecall_made

D. Barrettino, M. Graf, S. Taschini, S. Hafizovic, C. Hagleitner, A. Hierlemann, "CMOS monolithic metal-oxide gas sensor microsystems", IEEE Sensor Journal, Vol. 6, No. 2, 2006, pp. 276-286 (DOI: 10.1039/b511768b). external pageOnlinecall_made  

V. Linder, S. Koster, W. Franks, T. Kraus, E. Verpoorte, F. Heer, A. Hierlemann, N.F. de Rooij, "Microfluidics/CMOS orthogonal capabiliies for cell biology", Biomedical Microdevices, 8 (2006) 159-166 (DOI: 10.1007/s10544-006-7711-9). external pageOnlinecall_made

F. Heer, S. Hafizovic, W. Franks, A. Blau, C. Ziegler, A. Hierlemann, "CMOS microelectrode array for bidirectional interaction with neuronal networks", IEEE Journal of Solid-State Circuits, Vol. 41, No. 7 (2006) 1620-1629 (DOI: 10.1109/JSSC.2006.873677). external pageOnlinecall_made

P. Kurzawski, T. Salo, H. Baltes, A. Hierlemann, "Towards a versatile DRIE: Silicon Pit structures combined with electrochemical etch Stop", Journal of Microelectromechanical Systems, Vol. 15, No. 4 (2006) 840-848 (DOI: 10.1109/JMEMS.2006.878883). external pageOnlinecall_made

M. Graf, U. Frey, S. Taschini, A. Hierlemann, "Micro hot plate-based sensor array system for the detection of environmentally relevant gases", Analytical Chemistry, Vol. 78, No. 19 (2006) 6801-6808 (DOI: 10.1021/ac060467d). external pageOnlinecall_made

P. Kurzawski, C. Hagleitner, A. Hierlemann, "Detection and discrimination capabilities of a multitransducer single-chip gas sensor system", Analytical Chemistry, Vol. 78, No. 19 (2006) 6910-6920 (DOI: 10.1021/ac0610107). external pageOnlinecall_made

M. Graf, D. Barrettino, K.-U. Kirstein, A. Hierlemann, "CMOS microhotplate sensor system for operating temperatures up to 550°C", Sensors and Actuators B, 117 (2006) 346-352 (DOI: 10.1016/j.snb.2005.11.012). external pageOnlinecall_made

J.M. Kelm, V. Djonov, S.P. Hoerstrup,, C.I. Guenter, L.M. Ittner, F. Greve, A. Hierlemann, C.D. Sanchez-Bustamante, J.-C. Perriard, E. Ehler, M. Fussenegger, "Tissue-transplant fusion and vascularization of myocardial microtissues and macrotissues implanted into chicken embryos and rats", Tissue Engineering, Vol. 12, No. 9 (2006) 1 – 13.
Received the 2006 ESAO (European Society of Artificial Organs) Research Award (DOI: 10.1089/ten.2006.12.2541). external pageOnlinecall_made

G. Romera-Guereca, J. Lichtenberg, A. Hierlemann, D. Poulikakos, B. Kang, "Explosive vaporization in microenclosures", Experimental Thermal and Fluid Science, 30 (2006) 829-836 (DOI: 10.1016/j.expthermflusci.2006.03.012). external pageOnlinecall_made

M. Graf, A. Gurlo, N. Barsan, U. Weimar, A. Hierlemann, "Microfabricated gas sensor system with sensitive nanocrystalline metal-oxide films", Journal of Nanoparticle Research, 8 (2006) 823-839 (DOI: 10.1007/s11051-005-9036-7). external pageOnlinecall_made  

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2005

M. Graf, R. Jurischka, D. Barrettino, and A. Hierlemann, "3-D nonlinear modelling of microhotplates in CMOS technology for use as metal-oxide-based gas sensors", Journal of Micromechanics and Microengineering, 15 (2005) 190-200 (DOI: 10.1088/0960-1317/15/1/027). external pageOnlinecall_made

D. Barrettino, S. Hafizovic, T. Volden, J. Sedivy, K.-U. Kirstein, A. Hierlemann, "CMOS monolithic mechatronic microsystem for surface imaging and force response studies", IEEE Journal of Solid-State Circuits, 40 (2005) 951-959 (DOI:
10.1109/JSSC.2004.842868). external pageOnlinecall_made

M. Graf, S.K. Müller, D. Barrettino, A. Hierlemann,"Transistor heater for microhotplate-based metal-oxide microsensors", IEEE Electron Device Letters, 26 (2005) 295-297 (DOI: 10.1109/LED.2005.846899). external pageOnlinecall_made

C. Vancura, M. Rüegg, Y. Li, C. Hagleitner, A. Hierlemann, "Magnetically actuated complementary metal oxide semiconductor resonant cantilever gas sensor systems", Analytical Chemistry, 77 (2005) 2690-2699 (DOI: 10.1021/ac048378t). external pageOnlinecall_made

W. Franks, I. Schenker, P. Schmutz, A. Hierlemann, "Impedance characterization and modeling of electrodes for biomedical applications", IEEE Transactions on Biomedical Engineering, 52 (2005) 1295-1302 (DOI: 10.1109/TBME.2005.847523). external pageOnlinecall_made

C. Vancura, J. Lichtenberg, A. Hierlemann, "Characterization of magnetically actuated resonant cantilevers in viscous fluids", Applied Physics Letters, 87, (2005) 87-89 (DOI: 10.1063/1.2108130). external pageOnlinecall_made

T. Bechtold. E- B. Rudnyi, J.G. Korvink, M. Graf, A. Hierlemann, "Connecting heat transfer macromodels for array MEMS structures", Journal of Micromechanics and Microengineering, 15 (2005) 1205-1214 (DOI: 10.1088/0960-1317/15/6/010). external pageOnlinecall_made

A. Hierlemann, "Integrated chemical microsensor systems in CMOS technology", LabPlus international, Vol. 19, No. 4, Sept. 2005, 14-18 (DOI: 10.1109/SENSOR.2005.1497276). external pageOnlinecall_made

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2004

S. Hafizovic, D. Barrettino, T. Volden, J. Sedivy, K.-U. Kirstein, O. Brand, A. Hierlemann, "Single-chip mechatronic microsystem for surface imaging and force response studies", PNAS, Vol. 101, No. 49 (2004) 17011-17015 *(DOI: 10.1073/pnas.0405725101). external pageOnlinecall_made  

M. Graf, D. Barrettino, M. Zimmermann, A. Hierlemann, H. Baltes, S. Hahn, N. Bârsan, U. Weimar, "CMOS monolithic metal-oxide sensor system comprising a microhotplate and associated circuitry", IEEE Sensor Journal, Vol. 4 (2004) 9-16 (DOI:
10.1109/JSEN.2003.820367). external pageOnlinecall_made

A. Kummer, A. Hierlemann, H. Baltes, "Tuning Sensitivity and Selectivity of complementary metal oxide semiconductor-based capacitive chemical microsensors", Analytical Chemistry, 76 (2004) 2470-2477 (DOI: 10.1021/ac0352272). external pageOnlinecall_made

M. Graf, D. Barrettino, S. Taschini, C. Hagleitner, A. Hierlemann, H. Baltes, "Metal oxide-based monolithic complementary metal oxide semiconductor gas sensor microsystem", Analytical Chemistry, 76 (2004) 4437-4445 (DOI: 10.1021/ac035432h). external pageOnlinecall_made

D. Barrettino, M. Graf, M. Zimmermann, C. Hagleitner, A. Hierlemann, H. Baltes, "A smart single-chip micro-hotplate-based gase sensor system in CMOS-technology", Int. Journal on Analog Integrated Circuits and Signal Processing, 39 (2004) 275-287 (DOI: 10.1109/ISCAS.2002.1010948). external pageOnlinecall_made

F. Heer, W. Franks, A. Blau, S. Taschini, C. Ziegler, A. Hierlemann, H. Baltes, "CMOS microelectrode array for the monitoring of electrogenic cells", Biosensors & Bioelectronics, 20 (2004) 358-366 (DOI: 10.1016/j.bios.2004.02.006). external pageOnlinecall_made

M. Jenkner, M. Tartagni, A. Hierlemann, and R. Thewes, "Cell-Based CMOS Sensor and Actuator Arrays", IEEE Journal of Solid-State Circuits, Vol. 39, No. 12 (2004) 24312437 (DOI: 10.1109/JSSC.2004.837082). external pageOnlinecall_made

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2003

A. Hierlemann, O. Brand, C. Hagleitner, H. Baltes, "Microfabrication techniques for chemical/biosensors", Proceedings of the IEEE, 91 (6), 2003, 839-863. ISSN 0018-9219 (DOI: 10.1109/JPROC.2003.813583). external pageOnlinecall_made

A. Hierlemann, H. Baltes, "CMOS-based chemical microsensors", The Analyst, 128 (1), 2003, pp. 15-28 (DOI:  10.1039/B208563C). external pageOnlinecall_made

2002

W. Franks, D. Lange, S. Lee, A. Hierlemann, N. Spencer, H. Baltes, "Nanochemical surface analyzer in CMOS technology", Ultramicroscopy, 91 (1-4), 2002, 21 - 27. ISSN 0304-3991 (DOI: 10.1016/S0304-3991(02)00078-5). external pageOnlinecall_made

D. Lange, C. Hagleitner, A. Hierlemann, O. Brand, H. Baltes, "Complementary Metal Oxide Semiconductor Cantilever Arrays on a Single Chip: Mass-Sensitive Detection of Volatile Organic Compounds", Analytical Chemistry, 2002, 74 (13). pp. 3084-3095 (DOI: 10.1021/ac011269j). external pageOnlinecall_made

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2001

C. Hagleitner, A. Hierlemann, D. Lange, A. Kummer, N. Kerness, O. Brand, H. Baltes, "Smart single-chip gas sensor microsystem", Nature, 414 (6861), 2001, p. 293. (DOI: 10.1038/35104535). external pageOnlinecall_made

A. Hierlemann,H. Baltes, V. Schurig, "Search for extraterrestrial enantioenrichment by using chemical microsensors", Enantiomer, 6 (2-3), 2001, pp. 129-139. ISSN 1024-2430. external pageOnlinecall_made

A. Hierlemann, E.T. Zellers, A.J. Ricco, "Use of Linear Solvation Energy Relationships for Modeling Responses from Polymer-Coated Acoustic-Wave Vapor Sensors", Analytical Chemistry, 73 (14), 2001, pp. 3458-3466 (DOI: 10.1021/ac010083h). external pageOnlinecall_made

2000

A. Hierlemann, A.J. Ricco, K. Bodenhöfer, A. Dominik, W. Göpel, "Conferring Selectivity to Chemical Sensors via Polymer Side-Chain Selection: Thermodynamics of Vapor Sorption by a Set of Polysiloxanes on Thickness-Shear Mode Resonators", Anal Chem., 72 (2000) 3696-3708 (DOI: 10.1021/ac991298i). external pageOnlinecall_made

A. Hierlemann, A. Koll, D.Lange, C. Hagleitner, N. Kerness, O. Brand, H. Baltes, "Application-Specific Sensor Systems Based on CMOS Chemical Microsensors", Sensors and Actuators B, 70 (2000) 2-11 (DOI: 10.1016/S0925-4005(00)00546-3). external pageOnlinecall_made

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Before 2000

A. Hierlemann, A.J. Ricco, K. Bodenhöfer, W. Göpel, "Effective Use of Molecular Recognition in Gas Sensing: Results from Acoustic Wave and In-Situ FTIR Measurements", Anal. Chem., 71 (1999) 3022-3035 (DOI: 10.1021/ac981311j). external pageOnlinecall_made

A. Hierlemann, K. Bodenhöfer, M. Juza, B. Gross, V. Schurig, W. Göpel, "Enantioselective Monitoring of Chiral Inhalation Anesthetics by Simple Gas Sensors", Sensors and Materials, 11, 4 (1999) 209-218. ISSN: 0914-4935. external pageOnlinecall_made

R.C. Thomas, A. Hierlemann, A.W. Staton, M. Hill, and A.J. Ricco, "Reflectance Infrared Spectroscopy on Operating Surface Acoustic Wave Chemical Sensors during Exposure to Gas-Phase Analytes", Anal. Chem., 71 (1999) 3615-3621 (DOI: 10.1021/ac981447h). external pageOnlinecall_made

A. Hierlemann, J.C. Campbell, L. Baker, R.M. Crooks, A.J. Ricco, "Structural Distortion of Dendrimers on Gold Surfaces: A Tapping-Mode AFM Investigation", J. Am. Chem. Soc., 120 (1998) 5323-5324 (DOI: 10.1021/ja974283f). external pageOnlinecall_made

K. Bodenhöfer, A. Hierlemann, W. Göpel, M. Juza, B. Gross and V. Schurig, "Efficient Gas Sensor Mediated Enantiomer Discrimination of 2-Substituted Methyl Propionates and Chiral Inhalation Anaesthetics on a Modified Cyclodextrin", Chimica OGGI-Chemistry Today, 16 (1998) 56-58l, ISBN: 0392-839X. external pageOnlinecall_made

K. Bodenhöfer, A. Hierlemann, J. Seemann, G. Gauglitz, B. Koppenhoefer, W. Göpel, "Chiral Discrimination using Piezoelectric and Optical Gas Sensors", Nature, 387 (1997) 577-580 (DOI: 10.1038/42426). external pageOnlinecall_made

K. Bodenhöfer, A. Hierlemann, J. Seemann, G. Gauglitz, W. Göpel, "Chiral Discrimination in the Gas Phase Using Different Transducers: Thickness Shear Mode Resonators and Reflectometric Interference Spectroscopy", Anal. Chem., 69 (1997) 3058-3068 (DOI: 10.1021/ac9612990). external pageOnlinecall_made

K. Bodenhöfer, A. Hierlemann, R. Schlunk, and W. Göpel, "New Method of Vaporising Volatile Organics for Gas Tests", Sens. Actuators B, 45/3 (1997) 259-264 (DOI: 10.1016/S0925-4005(97)00319-5). external pageOnlinecall_made

K. Bodenhöfer, A. Hierlemann, M. Juza, V. Schurig, W. Göpel, "Chiral Discrimination of Inhalation Anesthetics and Methyl Propionates by Thickness Shear Mode Resonators: New Insights into the Mechanisms of Enantioselectivity by Cyclodextrins", Anal. Chem., 69 (1997) 4017-4031 (DOI: 10.1021/ac970367v). external pageOnlinecall_made

R. Zhou, A. Hierlemann, U. Weimar, W. Göpel, "Gravimetric, Dielectric and Calorimetric Methods for the Detection of Organic Solvent Vapours Using Polyetherurethane Coatings", Sens. Actuators B, 34 (1996) 356 (DOI: 10.1016/S0925-4005(96)01912-0). external pageOnlinecall_made

Marco, A. Pardo, F. Davide, C. DiNatale, A. D'Amico, A. Hierlemann, W. Göpel, "Different Strategies for the Dynamic Calibration of Gas Sensors", Sens. Actuators B, 34 (1996) 213-223 (DOI: 10.1016/S0925-4005(97)80001-9). external pageOnlinecall_made

A. Hierlemann, K. Bodenhöfer, M. Fluck, V. Schurig, W. Göpel, "Selective Detection of Nitrogen- and Oxygen-Containing Analytes Using Metal-Modified Polysiloxanes as sensor coatings", Anal. Chim. Acta, 346 (1997) 327-339 (DOI: 10.1016/S0003-2670(97)90073-8). external pageOnlinecall_made

A. Hierlemann, K. Bodenhöfer, G. Noetzel, U. Weimar, W. Göpel, "Performances of Mass-Sensitive Devices for Gas Sensing:  Thickness Shear Mode and Surface Acoustic Wave Transducers", Anal. Chem., 68 (1996) 2210-2218 (DOI: 10.1021/ac9600215). external pageOnlinecall_made

R. Zhou, A. Hierlemann, K.D. Schierbaum, K.E. Geckeler, W. Göpel, "Detection of Organic Solvents with Reliable Chemical Sensors Based on Cellulose Derivatives", Sens. Actuators B, 24-25 (1995) 443-447 (DOI: 10.1016/0925-4005(95)85099-6). external pageOnlinecall_made

C. DiNatale, F. Davide, A. D'Amico, A. Hierlemann, J. Mitrovics, M. Schweizer, U. Weimar, W. Göpel, "A composed neural net for the recognition of gas mixtures", Sens. Actuators B, 24-25 (1995) 808-812 (DOI: 10.1016/0925-4005(95)85180-1). external pageOnlinecall_made

F.A.M. Davide, C. DiNatale, A. D'Amico, A. Hierlemann, J. Mitrovics, M. Schweizer, U. Weimar, W. Göpel, "Structure Identification of Nonlinear Models for QMB Polymer-Coated Sensors", Sens. Actuators B, 24-25 (1995) 830-842 (DOI: 10.1016/0925-4005(95)85185-2). external pageOnlinecall_made

C. Cornila, A. Hierlemann, R. Lenggenhager, P. Malcovati, H. Baltes, G. Noetzel, U. Weimar, W. Göpel, "Capacitive Sensors in CMOS Technology with Polymer Coating", Sens. Actuators B, 24-25 (1995) 357-361 (DOI: 10.1016/0925-4005(95)85080-5). external pageOnlinecall_made

A. Hierlemann, U. Weimar, G. Kraus, G. Gauglitz, W. Göpel, "Environmental Chemical Sensing Using Quartz Microbalance Sensor Arrays: Application of Multicomponent Analysis Techniques", Sens. Materials, 7 (3) (1995) 179-189, ISSN: 0914-4935. external pageOnlinecall_made

J.W. Gardner, A. Pike, N. F. de Rooij, M. Koudelka-Hep, P. Clerc, A. Hierlemann, W. Göpel, "Integrated Array Sensor for Detecting Organic Solvents", Sens. Actuators B, 26-27 (1995) 135-139 (DOI: 10.1016/0925-4005(94)01573-Z). external pageOnlinecall_made

F.A.M. Davide, C. DiNatale, A. D'Amico, A. Hierlemann, J. Mitrovics, M. Schweizer, U. Weimar, W. Göpel, S. Marco, A. Pardo, "Dynamic Calibration of QMB Polymer-Coated Sensors by Wiener Kernel Estimation", Sens. Actuators B, 26-27 (1995) 275-285 (DOI: 10.1016/0925-4005(94)01601-D). external pageOnlinecall_made

M. Schweizer, J. Göppert, A. Hierlemann, J. Mitrovics, U. Weimar, W. Rosenstiel, W. Göpel, "Application of Neural Network Systems to the Dynamic Response of Polymer-Based Sensor Arrays", Sens. Actuators B, 26-27 (1995) 232-236 (DOI: 10.1016/0925-4005(94)01592-6). external pageOnlinecall_made

A. Hierlemann, U. Weimar, G. Kraus, M. Schweizer, W. Göpel, "Polymer-Based Sensor Arrays and Multicomponent Analysis for the Detection of Hazardous Organic Vapours in the Environment", Sens. Actuators B, 26-27 (1995) 126-134, (DOI: 10.1016/0925-4005(94)01572-4). external pageOnlinecall_made

K.D. Schierbaum, A. Hierlemann, W.Göpel, "Modified Polymers for Reliable Detection of Organic Solvents", Sens. Actuators B, 18-19 (1994) 448-452, (DOI: 10.1016/0925-4005(93)01034-2). external pageOnlinecall_made