Frey, Olivier, Dr.
- Integrated microfluidic systems for multi-cellular spheroids culturing and analysis (multi-tissue formats, body-on-a-chip approaches)
- Microfluidic devices for long-term cell culturing and analysis
- Electrochemical-based biosensors for neuroscience and biomedical applications
Since 2010 Scientist at Bio Engineering Laboratory (BEL) of ETHZ
2010 PostDoc at SAMLAB, BioMEMS and Microfluidics
2006-2010 EPFL, IMT Neuchatel, Studies towards Dr. Sc. at the Sensors, Actuators and Microsystems Laboratory (SAMLAB) of Nico F. de Rooij, in the BiosMEMS group of Milena Koudelka-Hep, "Biosensor Microprobe Arrays for In Vivo Monitoring of Neurotransmitters"
2005 Research assistant at PEL, ETHZ
2000-2005 ETH Zurich, Studies in mechanical engineering, Master thesis "Autonomous Multi-channel System for Polymerase Chain Reaction" at the Physical Electronics Laboratory (PEL).
Selected journal articles
O. Frey, P. M. Misun, D. A. Fluri, J. G. Hengstler, A. Hierlemann, Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis, Nature Communications, 5, 4250, 2014.
J. Rothe, O. Frey, A. Stettler, Y. Chen, A. Hierlemann, Fully Integrated CMOS Microsystem for Electrochemical Measurements on 32 × 32 Working Electrodes at 90 Frames Per Second, Analytical Chemistry, 86 (13), 2014, 6425-6432.
D. Ausländer, S. Ausländer, G. Charpin-El Hamri, F. Sedlmayer, M. Müller, O. Frey, A. Hierlemann, J. Stelling, M. Fussenegger, A Synthetic Multifunctional Mammalian pH Sensor and CO2 Transgene-Control Device, Molecular Cell, 55(3), 2014, 397–408.
O. Frey, P.D. van der Wal, S. Spieth, O. Brett, K. Seidl, O. Paul, P. Ruther, R. Zengerle, N.F. de Rooij, Biosensor Microprobes with Integrated Microfluidic Channels for Bi-Directional Neurochemical Interaction, Journal of Neural Engineering 8 (2011) 066001 (9pp)
O. Frey, T. Holtzman, R. McNamara, D.E.H. Theobald, P.D. van der Wal, N.F. de Rooij, J.W. Dalley, M. Koudelka-Hep, Enzyme-based choline and L-glutamate biosensor electrodes on silicon microprobe arrays, Biosensors and Bioelectronics 26 (2010) 477-484.
O. Frey, S. Talaei, P.D. van der Wal, M. Koudelka-Hep, N.F. de Rooij, Continuous-flow multi-analyte biosensor cartridge with controllable linear response range, Lab on a chip 10 (2010) 2226-2234.
Recent conference presentations
O. Frey, P.M. Misun, A. Hierlemann, Connecting hanging drops in a microfluidic network for compound testing in continuously perfused multi-tissue formats , DECHEMA 3D Cell Culture Conference, June 25 – June 27, 2014, Freiburg, Germany
O. Frey, P.M. Misun and A. Hierlemann, Hanging Microfluidics: A Highly Versatile Platform for Production and Cultivation of 3D Spherical Microtissues, 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS), Oct. 27 – Oct. 31, 2013, Freiburg, Germany, pp. 2016-2018
O. Frey, F. Rudolf, and A. Hierlemann, High-Resolution Live Cell Imaging of the Yeast Life Cycle , 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS), Oct. 28 – Nov. 1, 2012, Okinawa, Japan, pp. 1582-1584