Peng, Ren-Wang, Dr.

 

Biography

Ren-Wang Peng studied Chemistry and Biochemistry during his interdisciplinary Bachelor and Master training. After obtaining his PhD in Molecular Biology and Bioengineering from Chinese Academy of Sciences (CAS), Beijing, China, he immediately joined the Max-Planck-Institute for Biophysical Chemistry (MPIbpc) in Göttingen, Germany, first as a postdoctoral fellow and then a senior scientist, with in-between a short-term stay at Dartmouth Medical School in Hanover, NH, USA. From 2006 to 2010 he was an Oberassistent (group leader) in the Biotechnology and Bioengineering Laboratory at ETH Zürich, Switzerland. Currently he is a senior scientific assistant of clinical research at University Hospital Bern (Inselspital).

Research interests

• Bioengineering and bioprocess development of mammalian cell factories for industrial and therapeutic applications.

• Biochemical and cell biological analyses of intracellular protein trafficking (exo- & endocytosis).

• Molecular mechanisms underlying normal hematopoiesis and pathology of acute leukemias

Selected publications

Ye H, Daoud El Baba M, Peng RW, Fussenegger M (2011) A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice. Science 332: 1565-1568 (24 June 2011 issue).

Peng RW, Abellan E, Fussenegger, M. (2011) Differential effect of exocytic SNAREs on the production of recombinant proteins in mammalian cells. Biotechnology and Bioengineering 108: 611-620

Peng RW, Guetg C, Abellan E, Fussenegger, M. (2010) Munc18b regulates core SNARE complex assembly and constitutive exocytosis by interacting with the N-peptide and the closed-conformation C-terminus of syntaxin 3. Biochemical Journal 431, 353-361

Peng RW, Guetg C, Tigges M, Fussenegger M. (2010) The Vesicle-trafficking protein Munc18b increases the secretory capacity of mammalian cells. Metabolic Engineering 12, 18-25

Peng RW, Fussenegger M. (2009) Molecular engineering of exocytic vesicle traffic enhances the productivity of Chinese hamster ovary cells. Biotechnology and Bioengineering 102, 1170-1181.

Li Y, Schmitt HD, Gallwitz D, Peng RW. (2007) Mutations of the SM protein Sly1 resulting in bypass of GTPase requirement in vesicular transport are confined to a short helical region. FEBS Letter 581, 5698-5702.

Li Y, Gallwitz D, Peng RW. (2005) Structure-based functional analysis reveals a role for the SM protein Sly1p in retrograde transport to the ER. Molecular Biology of the Cell 16, 3951-3962 (corresponding author).

Peng R, Gallwitz D. (2004). Multiple SNARE interactions of an SM protein: Sed5p/Sly1p binding is dispensable for transport. EMBO Journal 23, 3939-3949.

Peng R, Gallwitz D. (2002). Sly1 protein bound to Golgi syntaxin Sed5p allows assembly and contributes to specificity of SNARE fusion complexes. Journal of Cell Biology 157, 645-655.

Peng R, De Antoni A, Gallwitz D. (2000). Evidence for overlapping and distinct functions in protein transport of coat protein Sec24p family members. Journal of Biological Chemistry 275, 11521-11528.

Peng R, Grabowski R, Gallwitz D. (1999). Specific interaction of the yeast cis-Golgi syntaxin Sed5p and the coat protein complex II component Sec24p of endoplasmic reticulum-derived transport vesicles. Proceedings of National Academy of Sciences of the United States of America 96, 3751-3756.

Peng R, Zhou X, Fang R, Chen Z, Mang K. (1998). Restoration to fertility of transgenic male sterile oilseed rape by specific expression of an RNase inhibitor. Journal of genetics and genomics 25, 74-79.

Zhou X, Peng R, Fang R, Chen Z, Mang K. (1997). Obtaining male sterile oilseed rape by specific expression of an RNase gene. Journal of genetics and genomics 24, 531-536.

Book chapters

Peng RW, Fussenegger M. (2009) Engineering the secretory pathway in mammalian cells. In Cell Line Development, Cell Engineering 6, M. Al-Rubeai (ed.). Springer (Dordrecht, Heidelberg, London, New York), ISBN 978-90-481-2244-8, pp.233-248.

Yu M, Peng R. (2000) The principles of genetic engineering. In Modern Microbiology and Experimental Technology. X. Huang and Zh. Lin (ed.). Science Press (Beijing), pp.3-33.

Patents

SM protein-based secretion engineering of Chinese hamster ovary (CHO) cells. US & International patent: application number 20090247609, PCT/EP2008/010882, filing date: 19.12.2008.