New in version 0.6 --------------------- + added support for SNV calling and strand bias test. + support for read alignment within shorah removed. Shorah now runs on an aligned, sorted bam files, or regions thereof. + iterations are now a function of window coverage (-j option removed). + added option to limit coverage New in version 0.5 --------------------- + SAM/BAM format added! Users can now produce MSA files from their alignments in SAM format + README and INSTALL have been updated, and more information is available on the web, at the ShoRAH documentation page https://wiki-bsse.ethz.ch/display/ShoRAH/Documentation New in version 0.4 --------------------- + dpm_sampler now computes Hamming distance in time proportional to the distance rather than to the length of the sequences. + dpm_sampler now clubs identical reads into objects. This method achieves a significant speed-up with Illumina datasets. Up to 65000 Illumina reads were analysed in a single window with good results. + freqEst sorts the output according to the frequency New in version 0.3 --------------------- + dpm_sampler is now C++! Thanks to the structures defined in C++ libraries (map and multimap), we are able to run requiring much less memory + Parallelization! dec.py now calls diri_sampler using a pool of independent workers, exploiting all the available compuational power, as well as s2f.py does + The sampling has been improved, now we can have a more reliable estimate of the quality of our local haplotype reconstruction + The output of diri_sampler is now better organized (if -k is given, all intermediate files are saved in subdirectories of the current) + The alignment program runs now in linear time (with respect to the number of reads), and deals with indels in a more clever way + All python programs now use the logging module to write logs of their operations + plot_sampling.py and plot_stat.py can be used to produce graph showing the behaviour of the Gibbs sampling New in version 0.2 --------------------- + New method to assign the reads after the sampling + The alignment is now provided by a separate program (step2far.py), so that the user can input his/her own alignment and install EMBOSS only if really necessary + Fixed numerical bugs when dealing with very high or very low probabilities