ETH - BSSE - CBG Simona Constantinescu

Our paper Reliable detection of subclonal
single-nucleotide variants in tumor cell populations appeared in Nature Communications today (see also ETH Life). In this work, we present the deepSNV algorithm and demonstrate its capability to detect subclonal mutations present in only 1/10,000 cells.

Gerstung et al. (2012) Nat Commun 3:811. DOI: 10.1038/ncomms1814.

	ETH Zurich, D-BSSE Computational Biology Group (CBG) Office: 8.46 Mattenstrasse 26 CH-4058 Basel, SWITZERLAND Phone: +41 61 387 32 03 Fax: +41 61 387 3994 E-Mail:simona.constantinescu@bsse.ethz.ch

Current Research Projects

Modeling of Cancer Progression based on Gene Expression Data;

Research Interests

Complex systems modeling in biology;
Cancer progression;
Evolutionary dynamics;
Synthetic biology;
Monotone control systems.

Publications

Papers

Kaltenbach, H.-M., Constantinescu, S., Feigelman, J. and Stelling, J., "Graph-Based Decomposition of Biochemical Reaction Networks into Monotone Subsystems", Proceedings of WABI 2011, volume 6833 of Lect. Notes Bioinformatics, pages 139-150. Springer, 2011 [pdf]

Master Thesis

Monotone Modules Approximation: Among the multitude of techniques used in modeling dynamical systems, the class of monotone (control) systems is primarily distinguished through a robust response to perturbations. In the context of biological systems, this feature is particularly appealing, since it provides a qualitative guarantee on the behavior of the system, under fluctuations in its parameter values. Decomposing a complex system into monotone modules and approximating their behavior (i.e. replacing them with simpler, yet similar subsystems) sheds new light into the intrinsic dynamical behavior of a monotone system. [pdf]

Curriculum Vitae

2011 - present	Since November, PhD Student at ETH Zürich, Department of Biosystems Science and Engineering (D-BSSE) Basel.
2009 - 2011	Master in Computational Biology and Bioinformatics (CBB), at ETH Zürich, Department of Computer Science (D-INFK).
2008 - 2009	Erasmus Exchange Student at Handelshögskolan, Faculty of Business, Economics and Law, University of Göteborg, Sweden.
2006 - 2009	Bachelor in Mathematics, University of Bucharest, Romania.
2006 - 2009	Bachelor in Economic Informatics, Faculty of Cybernetics, Statistics and Economic Informatics, Bucharest, Romania.
2002 - 2006	High - School Diploma in Mathematics, Mircea cel Bătrân National College, Constanta, Romania.

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