Dr. Samuel Ojosnegros

I have moved to Caltech !!

(new web page soon)

Research Interests

I'm interested in studying dynamical systems in biology from both experimental and theoretical point of view.

Some of the topics I have been involved in include:

Evolutionary Dynamics of RNA viruses

Evolution of virulence
Origins and evolution of viral genome segmentation
Genetic topology of quasispecies submitted to mutagenic treatment
Design of live-attenuated vaccines

Cell proliferation dynamics

In silico 2D-3D simulations of dynamic biological systems (download a movie)

Publications

Articles

• Ojosnegros S, Garcia-Arriaza J, Escarmís C, Manrubia S, Perales C, Arias A, Mateu MG and Domingo E. Increase in the stability of viral particles can drive the evolution of viral genome sgmentation. (Manuscript in preparation).
  
• Rodríguez-Calvo T, Ojosnegros S, Sanz-Ramos M, García-Arriaza J, Escarmís C, Domingo E and Sevilla N. New vaccine design based on defective genomes that combines features of attenuated and inactivated vaccines (Under review)
• Delgado-Eckert E, Ojosnegros S, Beerenwinkel N. The evolution of virulence in RNA viruses under a competition-colonization trade-off. Submitted.
  
• Ojosnegros S, Beerenwinkel N. Virus evolution and vaccine design. Open Applied Informatics Journal. In press (review).
  
• Ojosnegros S, Beerenwinkel N, Antal T, Nowak MA, Escarmís C, Domingo E. Competition-colonization dynamics in an RNA virus. Proc Natl Acad Sci U S A. 2010 Jan 13
• Ojosnegros S, Agudo R, Sierra M, Briones C, Sierra S, González-López C, Domingo E, Cristina J. Topology of evolving, mutagenized viral populations: quasispecies expansion, compression, and operation of negative selection.BMC Evol Biol. 2008 Jul 17;8:207
• García-Arriaza J, Ojosnegros S, Dávila M, Domingo E, Escarmís C. Dynamics of mutation and recombination in a replicating population of complementing, defective viral genomes. J Mol Biol. 2006 Jul 14;360(3):558-72. Epub 2006 May 24.

Talks

• RNA virus as an ecological succession
  VIII Jornada de Virologia 2008. Viral Quasispecies 30th aniversary. 17th November, Barcelona, Spain
• Information an noise management in RNA viruses

  Invited talk at ETH Zürich, Institute of Neuroinformatics, August 08, Zürich

• Dissecting fitness in RNA viruses: competitors vs. replicators
  Third European Congress of virology, September 07, Nüremberg
• Dissecting fitness in RNA viruses: competitors vs. replicators
  Invited talk at New England Primate Research Center, Harvard University, August, 07, Boston.
  

Thesis

• Dinamica evolutiva de virus RNA. Centro de Biología Molecular Severo Ochoa-Universidad Autonoma de Madrid (download)
  

Patents

Live-attenuated vaccine against foot-and-mouth disease virus with two steps of security.

Curriculum Vitae

2009-2010. Postdoc at California Institute of Technology. Scott Fraser's lab

2009. Postdoc at the Computational Biology Group, Department of Biosystems Science and Engineering of ETH Zurich.

2008. PhD Thesis. Center for Molecular Biology "Severo Ochoa", CSIC-UAM, under supervision of Prof. Esteban Domingo.

2007. Visiting researcher at Harvard University. Program for Evolutionary Dynamics. Martin A. Nowak's group.
2003. Bs. Biology. Universitat de Barcelona.