ETH - BSSE - CBG Janos Kelemen

Our paper Reliable detection of subclonal
single-nucleotide variants in tumor cell populations appeared in Nature Communications today (see also ETH Life). In this work, we present the deepSNV algorithm and demonstrate its capability to detect subclonal mutations present in only 1/10,000 cells.

Gerstung et al. (2012) Nat Commun 3:811. DOI: 10.1038/ncomms1814.

ETH Zurich, D-BSSE
Computational Biology Group (CBG)
Office: 8.46
Mattenstrasse 26
CH-4058 Basel, SWITZERLAND
Phone: +41 61 387 3306
Fax: +41 61 387 3992
E-Mail:janos.kelemen@bsse.ethz.ch

Current Research Projects

Detection of epistasis in high and ultra-high dimensional data, such as SNP data from GWAS. Alternative approaches to analyzing GWAS data.

Research Interests

Modeling and prediction within high-dimensional genomic and gene expression data.
Deterministic and stochastic dynamics and control in biological systems.

Publications

Selected Publications

Kelemen JZ, Ratna P, Scherrer S, Becskei A.
Spatial epigenetic control of mono- and bistable gene expression.
PLoS Biol. 2010 Mar 16;8(3):e1000332.
Buetti-Dinh A, Ungricht R, Kelemen JZ, Shetty C, Ratna P, Becskei A.
Control and signal processing by transcriptional interference.
Mol Syst Biol. 2009;5:300. Epub 2009 Aug 18.
Kelemen JZ, Kertész-Farkas A, Kocsor A, Puskás LG.
Kalman filtering for disease-state estimation from microarray data.
Bioinformatics. 2006 Dec 15;22(24):3047-53. Epub 2006 Oct 25.
Zvara A, Szekeres G, Janka Z, Kelemen JZ, Cimmer C, Sántha M, Puskás LG.
Over-expression of dopamine D2 receptor and inwardly rectifying potassium channel genes in drug-naive schizophrenic peripheral blood lymphocytes as potential diagnostic markers. Dis Markers. 2005;21(2):61-9.
Nagy ZB, Kelemen JZ, Fehér LZ, Zvara A, Juhász K, Puskás LG.
Real-time polymerase chain reaction-based exponential sample amplification for microarray gene expression profiling. Anal Biochem. 2005 Feb 1;337(1):76-83.

Other Publications

Vass L, Kelemen JZ, Fehér LZ, Lorincz Z, Kulin S, Cseh S, Dormán G, Puskás LG.
Toxicogenomics screening of small molecules using high-density, nanocapillary real-time PCR. Int J Mol Med. 2009 Jan;23(1):65-74.
Faragó N, Kocsis GF, Fehér LZ, Csont T, Hackler L Jr, Varga-Orvos Z, Csonka C, Kelemen JZ, Ferdinandy P, Puskás LG.
Gene and protein expression changes in response to normoxic perfusion in mouse hearts. J Pharmacol Toxicol Methods. 2008 Mar-Apr;57(2):145-54. Epub 2008 Jan 17.
Fehér LZ, Balázs M, Kelemen JZ, Zvara A, Németh I, Varga-Orvos Z, Puskás LG.
Improved DOP-PCR-based representational whole-genome amplification using quantitative real-time PCR.
Diagn Mol Pathol. 2006 Mar;15(1):43-8. Erratum in: Diagn Mol Pathol. 2006 Jun;15(2):123.
Puskás LG, Nagy ZB, Kelemen JZ, Rüberg S, Bodogai M, Becker A, Dusha I.
Wide-range transcriptional modulating effect of ntrR under microaerobiosis in Sinorhizobium meliloti.
Mol Genet Genomics. 2004 Oct;272(3):275-89. Epub 2004 Sep 9.

Curriculum Vitae

2010	Postdoc at the D-BSSE of ETHZ, Basel, Switzerland.
2007 - 2010	Postdoc at the Institute of Molecular Biology, University of Zurich, Zurich, Switzerland.
2003 - 2007	PhD at the University of Szeged, Biology Doctoral School, Szeged, Hungary. Research at the Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary.
1997 - 2003	Diploma – equivalent to MS degree, Engineering – Automatic Control and Industrial Informatics, Petru Maior University, Tirgu Mureş, Romania.

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