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Juliane Siebourg
News
May 1
Our paper Reliable detection of subclonal
single-nucleotide variants in tumor cell populations appeared in Nature Communications today (see also ETH Life). In this work, we present the deepSNV algorithm and demonstrate its capability to detect subclonal mutations present in only 1/10,000 cells.
Gerstung et al. (2012) Nat Commun 3:811. DOI: 10.1038/ncomms1814.
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Current Research Projects
Stability of rankings from RNA interference microscopy image screens.
Reconstruction of signaling pathways from RNA interference microscopy image screens.
Research Interests
- Statistical learning
- Bayesian Networks
- Discrete Mathematics
- Computational Geometry
Publications
Papers
- Siebourg, J., Merdes, G., Misselwitz, B., Hardt, W.-D., and Beerenwinkel, N. (2012). Stability of gene rankings from RNAi screens. Bioinformatics, doi: 10.1093/bioinformatics/bts192
- Bernhardt J, Funke S, Siebourg J, Hecker M (2009), Visualizing Gene Expression Data via Voronoi Treemaps, Proceedings of the ISVD 2009.
- Otto A, Bernhardt J, Meyer H, Schaffer M, Herbst F.A, Siebourg J, Mäder U, Lalk M, Hecker M, Becher D (2010), Systems-wide temporal proteomic profiling in glucose-starved Bacillus subtilis, Nature Communications 1(9).
Book chapter
- Beerenwinkel N, and Siebourg J, (2012), Probability Statistics and Computational Science, In M. Anisimova (ed.), Evolutionary Genomics: Statistical and Computational Methods, Volume 1, Methods in Molecular Biology, vol. 855, Springer, doi: 10.1007/978-1-61779-582-4_3.
Thesis
- Visualizing biological data with Voronoi based Treemap layouts Diplomarbeit (Master's Thesis), 2009.
Curriculum Vitae
| 2009 |
Since October, PhD student at the D-BSSE of ETH Zurich. |
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2009 |
Diplom (Master's degree) in Biomathematics from the University of Greifswald, Germany. Thesis: Visualizing biological data with Voronoi based Treemap layouts. |
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2006 |
Semester abroad at Massey University, Palmerston North, New Zealand |
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2003 |
High school (Abitur) at the Pädagogium Otto Kühne Schule, Bonn, Germany. |
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