Dr. Edgar Delgado-Eckert

Current Research Projects

• Reconstruction of signaling pathways from RNAi screens.
• Quantitative assessment of redundancy in protein interaction networks.
• Mathematical modeling of viral infection and viral competition.
• Evolution of virulence in inter-host viral populations.
• Epidemics in social networks.
  

Research Interests

• Mathematical modeling and inference in Biology.
• Dynamical and control systems.
• Computational algebra.
• Catastrophe Theory.
• Discrete Mathematics.
• Applications of algebraic geometry.

Publications in peer-reviewed journals

• Shapiro M, Delgado-Eckert E. (2012) Saturation effects on T-cell activation in a model of a multi-stage pathogen. In: Mondaini RP, editor. BIOMAT 2012: International Symposium on Mathematical and Computational Biology; Tempe, Arizona, USA. World Scientific.
  
• Kerner, R., Delgado-Eckert, E., Del Castillo, E., Müller-Starck, G., Peter, M., Küster B., Tisserant, E., Pritsch, K. (2012). Comprehensive proteome analysis in Cenococcum geophilum Fr. as a tool to discover drought-related proteins. Journal of Proteomics.
• Shapiro M., Delgado-Eckert E. (2012). Finding the probability of infection in an SIR network is NP-Hard. Mathematical Biosciences.
• Ojosnegros S^*., Delgado-Eckert E^*., Beerenwinkel N. (2012). Competition-colonization trade-off promotes coexistence of low-virulence viral strains. Journal of the Royal Society Interface. doi: 10.1098/​rsif.2012.0160
  
• Delgado-Eckert, E., Shapiro, M. (2011). A model of host response to a multi-stage pathogen. Journal of Mathematical Biology. 63(2): 201-227.
• Delgado-Eckert E., Ojosnegros S., Beerenwinkel N. (2010). The evolution of virulence in RNA viruses under a competition-colonization trade-off. Bulletin of Mathematical Biology. DOI: 10.1007/s11538-010-9596-2.
• Delgado-Eckert E. (2009). An algebraic and graph theoretical framework to study monomial dynamical systems over a …finite fi…eld. Complex Systems, Volume 18, Number 3.
  
• Delgado-Eckert E. (2009). Boolean Monomial Control Systems. Mathematical and Computer Modelling of Dynamical Systems, Volume 15, Issue 2. doi:10.1080/13873950902808594.
• Delgado-Eckert E. (2009). Reverse engineering time discrete finite dynamical systems: A feasible undertaking? PLoS ONE 4(3): e4939. doi:10.1371/journal.pone.0004939.
• Delgado-Eckert E. Canonical representatives for residue classes of a polynomial ideal and orthogonality. Embedded in the previous article. http://arxiv.org/abs/0706.1952v1
• Shapiro M., Duca K. A., Delgado-Eckert E. et al. (2008). A Virtual Look at Epstein-Barr Virus Infection: Simulation Mechanism. Journal of Theoretical Biology, 252(4):633-48. Epub Feb 16 2008.
• Duca, K.A., Shapiro, M., Delgado-Eckert, E.,  et al. (2007). A Virtual Look at Epstein-Barr Virus Infection: Biological Interpretations. PLoS Pathogens 3(10): e137.

Book chapters

• Edgar Delgado-Eckert and Niko Beerenwinkel (in press). Genetic Interactions and Network Reliability, in Linking Phenotypes with Genotypes, Florian Markowetz and Michael Boutros (Eds.), Cambridge University Press.
• Edgar Delgado-Eckert, Johann Reger and Klaus Schmidt (2011). Discrete Time Systems with Event-Based Dynamics: Recent Developments in Analysis and Synthesis Methods, in Discrete Time Systems, Mario Alberto Jordán (Ed.), ISBN: 978-953-307-200-5.

Education

• Ph.D. (Bio-)Mathematics, Magna Cum Laude, Technische Universität München, Munich, Germany. (Research performed at Tufts University's Medical School, Boston and at Virginia Bioinformatics Institute at Virgina Tech.)

• M.S. Mathematics (German Diplom-Mathematiker Univ.), Technische Universität München, Germany.
• Major: Mathematics.
• Minor: Physics.
  

Presentations

• Delgado-Eckert, E. (February 2012) The evolution of virulence in RNA viruses under a competition-colonization trade-off. Invited presentation at the Departamento de Estadística e Investigación Operativa I, Facultad de Ciencias Matemáticas, Universidad Complutense Madrid, Spain.
• Delgado-Eckert, E. (July 2011). A model of host response to a multi-stage pathogen. Invited presentation at the Department of Applied Mathematics, University of Leeds, UK.
  
• Delgado-Eckert, E. (June 2011). A model of host response to a multi-stage pathogen. Contributed talk at the 8th European Conference on Mathematical and Theoretical Biology, and 2011 Annual Meeting of The Society for Mathematical Biology, Kraków, Poland.
• Delgado-Eckert, E. (April 2011).  A model of host response to a multi-stage pathogen. Poster presented at the "Physics of Immunity: Complexity Approach"-Workshop at the Max Planck Institute for the Physics of Complex Systems, Dresden, Germany.
• Delgado-Eckert, E. (March 2011) The evolution of virulence in RNA viruses under a competition-colonization trade-off. Invited presentation at the Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany.
• Delgado-Eckert, E., Shapiro, M. (October 2010).  A model of host response to a multi-stage pathogen. Poster presented at the 11th International Conference on Systems Biology, Edinburgh, UK.
• Delgado-Eckert, E., Gill, S., Merdes, G., Beerenwinkel, N. (September 2010).  Predicting genetic interactions by quantifying redundancy in biochemical pathways. Poster presented at the 9th European Conference on Computational Biology, Ghent, Belgium.
• Delgado-Eckert, E. (July 2010) The evolution of virulence in RNA viruses under a competition-colonization trade-off. Contributed talk at the 2010 Annual Meeting of the Society for Mathematical Biology, Rio de Janeiro, Brazil.
  
• Delgado-Eckert, E. (April 2010) The evolution of virulence in RNA viruses under a competition-colonization trade-off. Invited presentation at the Pasteur Institute, Paris, France.
  
• Delgado-Eckert, E., Merdes, G., Beerenwinkel, N. (June 2009) Quantifying Redundancy in Signaling Pathways from Perturbation Experiments. Poster presented at the 7th Basel Computational biology Conference 2009, Switzerland.
• Delgado-Eckert, E. (March 2008) A Virtual look at Epstein-Barr virus infection. Invited presentation at the Broad Institute of MIT and Harvard University, Boston.
• Delgado-Eckert, E. (April 2007) Canonical representatives for residue classes of a polynomial ideal and orthogonality. Invited presentation at the Mathematics Department at the University of Puerto Rico, Mayagüez.
• Castiglione, F., Delgado-Eckert, E. (2006), Equation-based approximation of agent based models. Poster presented at the VBI 1st Annual Research Symposium, March 2006, Virginia Tech, Blacksburg, Virginia.
• Astorga, L., Delgado-Eckert, E. A brief introduction to Catastrophe Theory. Presented during the XII Jornadas Matemáticas Venezolanas, March 1999, Escuela de Matemática, UCV, Caracas, Venezuela.

Awards

• Travel award of the European Society for Mathematical and Theoretical Biology, June 2011.
  
• Landahl travel award of the Society for Mathematical Biology, July 2010.
• Graduate research fellowship from the Bavarian State, October 2003 - March 2006.