Publications Martin Held

The BPL is now at the D-BSSE in Basel

The Bioprocess Laboratory is now situated at the Biopark Rosental in Basel, building WRO-1058.
Our new address :
ETH Zürich
Department of Biosystems Science and Engineering (D-BSSE)
Mattenstrasse 26
4058 Basel, Switzerland
For more detailed information on how to find us >>

1. Suske, W., Held, M., Schmid, A., Wubbolts, M. G., Kohler, H.-P. E. 2 hydroxybiphenyl 3-monooxygenase, a noval member of the group of FAD-containing aromatic hydroxylases (1996) in: Flavins and Flavoproteins, University of Calgary Press: 383-386.
2. Suske, W. A., Held, M., Schmid, A., Fleischmann, T., Wubbolts, M. G., Kohler, H.-P. E. Purification and characterization of 2-hydroxybiphenyl 3-monooxygenase, a novel NADH-dependent, FAD-containing aromatic hydroxylase from Pseudomonas azelaica HBP1 (1997) J Biol Chem 272 (39): 24257-24265.
3. Held, M., Suske, W., Schmid, A., Engesser, K.-H., Kohler, H.-P. E., Witholt, B., Wubbolts, M. G. Preparative scale production of 3-substituted catechols using a novel monooxygenase from Pseudomonas azelaica HBP 1 (1998) J Mol Cat B: Enzymatic 5 (1-4): 87-93.
4. Held, M., Panke, S., Kohler, H.-P. E., Feiten, H.-J., Schmid, A., Wubbolts, M. G., Witholt, B. Solid phase extraction for biocatalytic production of toxic compounds (1999) Bioworld 5: 2-9
5. Held, M., Schmid, A., Kohler, H.-P. E., Suske, W., Witholt, B., Wubbolts, M. G. An Integrated Process to Produce Toxic Catechols from Phenols using a Designer Biocatalyst (1999) Biotech Bioeng 62 (6): 641-648
6. Witholt, B., Fussenegger, M., Held, M., Renner, W., Röthlisberger, P., Sauer, U. Bailey, J. Start-up-Firmen in der Biotechnologie (1999) IO Management 6: 116-121
7. Schmid, A., Wubbolts, M. G., Held, M., Witholt, B. Pseudomonas, process applications (1999) in: Flavins and Flavoproteins, Encyclopedia of Bioprocesses, John Wiley & Sons, Inc.: 2223-2232
8. Held, M., Schmid, A., Van Beilen, J. B., Witholt, B. (2000) Biocatalysis: Biological systems for the production of chemicals Pure Appl Chem 72 (7): 1337-1343
9. Schmid, A., Vereyken, I., Held, M., Witholt, B. Preparative regio- and chemoselective functionalization of hydrocarbons catalyzed by cell free preparations of 2 hydroxybiphenyl 3-monooxygenase (2001) J Mol Cat B: Enzymatic 11 (4-6): 455-462.
10. Panke, S., Held, M., Wubbolts, M. G., Witholt, B., Schmid, A. Pilot-scale production of (S)-styrene oxide from styrene by recombinant Escherichia coli synthesizing styrene monooxygenase (2002) Biotech Bioeng 80 (1): 33-41.
11. Meyer, A., Schmid, A., Held, M., Westphal, A. H., Röthlisberger, M., Kohler, H.-P. E., Van Berkel, W. J. H., Witholt, B. Changing the substrate reactivity of 2-hydroxybiphenyl 3 monooxygenase from Pseudomonas azelaica HBP1 by directed evolution (2002) J Biol Chem 277 (7): 5575-5582.
12. Meyer, A., Held, M., Schmid, A., Kohler, H.-P. E., Witholt, B. Synthesis of 3-tert-butylcatechol by an engineered monooxygenase (2003) Biotech Bioeng 81 (5): 518-524.
13. Panke, S., Held, M., Wubbolts, M. Trends and innovations in industrial biocatalysis for the production of fine chemicals (2004) Curr Opin Biotech 15 (4): 272-279
14. Brethauer, S., Held, M., Panke, S. Online medium-throughput respirometry-based OTR measurements in magnetically stirred cultures (2007) Biotech Bioeng 98 (2): 356-367.
15. Li, Z., Held, M., Panke, S., Schmid, A., Mathys, R., Witholt, B. Biocatalysis for industrial green chemistry (2007) Eds: Tundo, P., Perosa, A., Zecchini, F. in: Methods and Reagents for Green Chemistry, John Wiley & Sons, Inc.: 281-298.
16. Bechtold, M., Felinger, A., Held, M., Panke, S. Adsorption behavior of a teicoplanin aglycone bonded stationary phase under harsh overload conditions (2007) J Chrom A 1154 (1-2): 277-286.
17. Valsesia, G., Medaglia, G., Held, M., Minas, W., Panke, S. Circumventing the effect of product toxicity: development of a novel two-stage production process for the lantibiotic gallidermin (2007) Appl Environ Microbiol 73 (5): 1635-1645.
18. Brethauer, S., Held, M., Panke, S. Clavulanic acid decomposition is catalyzed by the compound itself and by its decomposition products (2008) J Pharm Sciences 97 (8): 3451-3455.
19. Brethauer, S., Held, M., Panke, S. High concentrations of clavulanic acid but not of its degradation products decrease glycerol consumption and oxygen uptake rates in cultures of Streptomyces clavuligerus (2008) Biotech Bioeng 100 (3): 439-447.
20. Walser, M., Leibundgut, R. M., Pellaux, R., Panke, S., Held, M. Isolation of monoclonal microcarriers colonized by fluorescent E. coli (2008) Cytometry Part A 73 (9): 788-98
21. Walser, M., Pellaux, R., Meyer, A., Bechtold, M., Vanderschuren, H., Reinhardt, R., Magyar, J., Panke, S., Held, M. Novel method for high-throughput colony PCR screening in nanoliter-reactors (2009) 37 (8): e57/1-e57/8

Patents

1. Held, Martin, Pellaux, Rene, Heile, Jens-Martin, Schenzle, Andreas Josef Encapsulation of sorbents in acrylamide copolymers for use in bioprocesses. Eur. Pat. Appl. (2003) EP 1306128 A1 20030502
2. Held, Martin, Pellaux, Rene, Heile, Jens-Martin, Schenzle, Andreas Josef Screening for compounds having an effect on cells using microtiter plates. PCT Int. Appl. (2003) WO 2003100085 A1 20031204
3. Brand, Oliver, Held, Martin, Hierlemann, Andreas, Lange, Dirk Microsensor system for monitoring biological and chemical processes. Eur. Pat. Appl. (2003) EP 1284158 A2 20030219
4. Pellaux, Rene, Heile, Jens-Martin, Schenzle, Andreas Josef, Held, Martin Method for the concentration and purification of biological compounds. PCT Int. Appl. (2005) WO 2005058453 A1 20050630
5. Held, Martin, Leviev, Ilia, Magyar, Josef P., Panke, Sven, Pellaux, Rene, Reinoso-Garcia, Marta Maria, Silverberg, Eve, Walser, Marcel Parallel sequencing of nucleic acids in encapsulated cells. PCT Int. Appl. (2006) WO 2006125458 A1 20061130
6. Panke, Sven; Pellaux, Rene; Held, Martin; Meyer, Andreas Suspension arrays for species-species interaction studies PCT Int. Appl. (2009) WO 2009132820 A1 20091105