Heer, Flavio, Dr.

Work Information

As a researcher at the Physical Electronics Laboratory I am mainly working on the monolithic integration of CMOS-based biosensor chips. The main work topics inlcude:

• CMOS analog and mixed signal circuit design
• System-level design
• Packaging
• Transducer modeling

Publications

Journal Articles

• F. Heer, S. Hafizovic, T. Ugniwenko, U. Frey, W. Franks, E, Perriard, J.-C. Perriard, A. Blau, C. Ziegler, A. Hierlemann, “Single-Chip Microelectronic System to Interface with Living Cells", Biosensors & Bioelectronics, vol. 22, no. 11, pp. 2546-2553, 2007.
• S. Hafizovic, F. Heer, T. Ugniwenko, A. Blau, C. Ziegler, A. Hierlemann, “A CMOS-based Microelectrode Array for Interaction with Neuronal Cultures”, J Neuroscience Methods, (available online).
• W. Franks, S. Tosatti, F. Heer, P. Seif, M. Textor, A. Hierlemann, “Self-Assembled Structures for Patterned Cell Adhesion on a CMOS Cell-Based Biosensor”, Biosensor & Bioelectronics, vol. 22, no. 7, pp. 1426-1433, 2007.
• F. Heer, S. Hafizovic, W. Franks, A. Blau, C. Ziegler, A. Hierlemann; "Metal-electrode-based CMOS microsystem for interfacing with neuronal networks", IEEE Journal of Solid-State Circuits, vol. 41, no. 7, 2006.
• F. Heer, S. Hafizovic, T. Ugniwenko, U. Frey, W. Franks, A. Blau, C. Ziegler, J.-C. Perriard, A. Hierlemann;Single-Chip Microelectronic System to Interface with Living Cells, Biosensors & Bioelectronics (2006) in press, doi:10.1016/j.bios.2006.10.003
• F. Heer, W. Franks, A. Blau, S. Taschini, C. Ziegler, A. Hierlemann, and H. Baltes, CMOS microelectrode array for the monitoring of electrogenic cells, Biosensors & Bioelectronics, vol. 20, no. 2, pp. 358 - 366, 9 2004.
• T. Kraus, E Verpoorte, V Linder, W Franks, A Hierlemann, F Heer, S Hafizovic, T Fujii, Nico F. de Rooij and S Koster, Characterization of a microfluidic dispensing system for localised stimulation of cellular networks, Lab on Chip, no. 6, pp. 218-229, 2006.
• V. Linder, S. Koster, W. Franks, T. Kraus, E. Verpoorte, F. Heer, A. Hierlemann, N. F. de Rooij, "Microfluidics/CMOS orthogonal capabilities for cell biology", Biomed Microdevices (2006), vol. 8, pp. 159–166 .

Book Chapters

• F. Heer and A. Hierlemann, “Integrated Microelectrode Arrays”, Chapter 9 in "BioCMOS Technologies" in Springer's Integrated Circuits and Systems Series.

Selected Conference Contributions

• F. Heer, M. Keller, G. Yu, J. Janata, M. Josowicz, A. Hierlemann, “A CMOS Electro-Chemical DNA Detection Array with On-Chip ADC”, to be presented at ISSCC 2008, San Francisco, United States.
• F. Heer, S. Hafizovic, T. Ugniwenko, U. Frey, B. Roscic, A. Blau, and A. Hierlemann, “Using microelectronics technology to communicate with living cells”, in Proc. IEEE EMBC Conf., Lyon, France, 2007, pp. 6077-6080.
• U. Frey, F. Heer, R. Pedron, S. Hafizovic, F. Greve, J. Sedivy, K.-U. Kirstein, A. Hierlemann, “11k-Electrode, 126-Channel, High-Density Microelectrode Array to Interact with Electrogenic”, ISSCC 2007, San Francisco, United States.
• U. Frey, F. Heer, R. Pedron, F. Greve, S. Hafizovic, K.-U. Kirstein, A. Hierlemann, „11’000 Electrode-, 126 Channel-CMOS Microelectrode Array for Electrogenic Cells”, MEMS 2007, Kyoto,
  Japan.
• S. Hafizovic, F. Heer, W. Franks, A. Blau, C. Ziegler, A. Hierlemann, “CMOS Bidirectional Electrode Array for Electrogenic Cells”, MEMS 2006, Istanbul, Turkey.
• F. Heer, S. Hafizovic, W. Franks, T. Ugniwenko, A. Blau, C. Ziegler, and A. Hierlemann, “Fully integrated 128-electrode CMOS chip for bidirectional interaction with electrogenic cells”, in Eurosensors XIX, Barcelona, Spain, 2005.
• F. Heer, S. Hafizovic, W. Franks, T. Ugniwenko, A. Blau, C. Ziegler, and A. Hierlemann, “CMOS microelectrode array for bidirectional interaction with neuronal networks”, in Proc. Eur. Solid-State
  Circuits Conf., Grenoble, France, 2005, pp. 335-338.