Research and Thesis Projects

ETH Zurich uses SiROP to publish and search scientific projects. For more information visit external pagesirop.org.

Controlled patterning of organoids

During development cells must assume different fates in a position-dependent manner. Morphogen gradients are able to encode this positional information, in order to guide tissue patterning during embryonic development. In the French flag model of patterning, morphogen concentration levels determine tissue domains of different cell fates. However, current in vitro 3D cell models fail to reproduce the patterning observed in vivo. Our aim is to generate 3D cell models which are able to reproduce patterning, thus allowing us to study morphogen gradients in diverse stages of development. Show details 

Monitoring in-vitro neural network dynamics using microelectrode arrays

The student will culture neurons on a microelectrode array, and will record the electrical activity of the network and follow its evolution over time. The development of new methods for signal processing, neuron stimulation, and imaging can be included in the project depending on the experience and interests of the student. Show details 

FPGA-based platform for controlling in-vitro neuronal cultures

The student will develop an FPGA-based platform for interacting with in-vitro neuronal cultures, including real-time spike detection and neuron stimulation. The project is focused on VHDL programming, although it could include other software development and/or wet-lab tasks with neurons depending on the interests of the student. Show details 

Microelectronic circuit design for neural interfaces in 0.18um CMOS technology

This project is about the development of integrated circuits to study neurons and neural networks, and may comprise different parts of the design including analog and/or digital microelectronics, PCB design, signal processing and programming. Show details 

Software development for neural interfaces

The student will be involved in the development of software applications for in-vitro neural interfaces. These applications include tasks such as visualizing neural recordings, real-time signal processing, and interfacing with our CMOS-based systems. Show details 

Microfabrication / nanofabrication of 3D nanostructures on micro-electrode arrays for high coupling neuron-chip interface

The Bio Engineering Lab (ETH Zurich, based in Basel) has a long tradition of pioneering densely-integrated CMOS devices capable of electrically interfacing with an in vitro neuronal systems (e.g. cultures, brain slices etc.). This position invites you to work on the fabrication methods and/or characterization of novel 3D structures that promote a strong coupling between the two heterogeneous systems, namely CMOS sensor chips and in vitro neurons. Show details 

Microfabrication and characterization of electrodes for neural interfaces

The focus of this project is on the intricate fabrication of microelectrodes for advanced neural interfaces in a cutting-edge cleanroom environment. Our research aims to develop high-resolution neural probes utilizing state-of-the-art microfabrication techniques. Show details 

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